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B0X9V1

- FBSP1_CULQU

UniProt

B0X9V1 - FBSP1_CULQU

Protein

F-box/SPRY domain-containing protein 1

Gene

Fsn

Organism
Culex quinquefasciatus (Southern house mosquito) (Culex pungens)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromuscular junction (NMJ).By similarity

    Pathwayi

    GO - Biological processi

    1. negative regulation of synaptic growth at neuromuscular junction Source: UniProtKB
    2. nervous system development Source: UniProtKB-KW
    3. neuromuscular synaptic transmission Source: UniProtKB
    4. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Biological processi

    Neurogenesis, Ubl conjugation pathway

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box/SPRY domain-containing protein 1By similarity
    Gene namesi
    Name:FsnBy similarity
    ORF Names:CPIJ016123
    OrganismiCulex quinquefasciatus (Southern house mosquito) (Culex pungens)
    Taxonomic identifieri7176 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex
    ProteomesiUP000002320: Partially assembled WGS sequence

    Subcellular locationi

    Cell junctionsynapse By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. neuromuscular junction Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 258258F-box/SPRY domain-containing protein 1PRO_0000383309Add
    BLAST

    Interactioni

    Subunit structurei

    Component of an E3 ubiquitin ligase complex composed of hiw and Fsn.By similarity

    Protein-protein interaction databases

    STRINGi7176.CPIJ016123-PA.

    Structurei

    3D structure databases

    ProteinModelPortaliB0X9V1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 5449F-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini64 – 256193B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FBXO45/Fsn family.Curated
    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
    Contains 1 F-box domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG263387.
    HOGENOMiHOG000230524.
    KOiK10319.
    OMAiILDCDDN.
    OrthoDBiEOG7QZGBV.
    PhylomeDBiB0X9V1.

    Family and domain databases

    InterProiIPR001870. B30.2/SPRY.
    IPR008985. ConA-like_lec_gl_sf.
    IPR001810. F-box_dom.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view]
    PfamiPF12937. F-box-like. 1 hit.
    PF00622. SPRY. 1 hit.
    [Graphical view]
    SMARTiSM00256. FBOX. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF81383. SSF81383. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50181. FBOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0X9V1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDDDLTEYAP DIPDNVLELI FSYLKLQDLR NCALVCKSWH RFLSDENNEV    50
    WRAQCMQKLS PDAFKTDLLS VVPTYKAKLR AFFHAWNPYD CSRHVYIKPN 100
    GFTLHRNPVA QSTDGSRGKI GFQHGRHAWE VRWEGPLGTV AVVGIATKDA 150
    AIQCHGYYAL LGADDQSWGW NLVDNLLLHN GDAHGIYPLL NNAPKYKVGE 200
    RIRVILDCDD NTLSFEKNYE FLGVAFTDLP DKVFYPTVAA VYGNTEISMV 250
    YLGPPLDG 258
    Length:258
    Mass (Da):29,186
    Last modified:April 8, 2008 - v1
    Checksum:i6C48CF803C93BF6D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS232551 Genomic DNA. Translation: EDS43303.1.
    RefSeqiXP_001866423.1. XM_001866388.1.

    Genome annotation databases

    EnsemblMetazoaiCPIJ016123-RA; CPIJ016123-PA; CPIJ016123.
    GeneIDi6049704.
    KEGGicqu:CpipJ_CPIJ016123.
    VectorBaseiCPIJ016123. Culex quinquefasciatus.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS232551 Genomic DNA. Translation: EDS43303.1 .
    RefSeqi XP_001866423.1. XM_001866388.1.

    3D structure databases

    ProteinModelPortali B0X9V1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7176.CPIJ016123-PA.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CPIJ016123-RA ; CPIJ016123-PA ; CPIJ016123 .
    GeneIDi 6049704.
    KEGGi cqu:CpipJ_CPIJ016123.
    VectorBasei CPIJ016123. Culex quinquefasciatus.

    Phylogenomic databases

    eggNOGi NOG263387.
    HOGENOMi HOG000230524.
    KOi K10319.
    OMAi ILDCDDN.
    OrthoDBi EOG7QZGBV.
    PhylomeDBi B0X9V1.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Family and domain databases

    InterProi IPR001870. B30.2/SPRY.
    IPR008985. ConA-like_lec_gl_sf.
    IPR001810. F-box_dom.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view ]
    Pfami PF12937. F-box-like. 1 hit.
    PF00622. SPRY. 1 hit.
    [Graphical view ]
    SMARTi SM00256. FBOX. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF81383. SSF81383. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50181. FBOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JHBImported.

    Entry informationi

    Entry nameiFBSP1_CULQU
    AccessioniPrimary (citable) accession number: B0X9V1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3