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Protein

F-box/SPRY domain-containing protein 1

Gene

Fsn

Organism
Culex quinquefasciatus (Southern house mosquito) (Culex pungens)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromuscular junction (NMJ).By similarity

Pathwayi

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurogenesis, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/SPRY domain-containing protein 1By similarity
Gene namesi
Name:FsnBy similarity
ORF Names:CPIJ016123
OrganismiCulex quinquefasciatus (Southern house mosquito) (Culex pungens)
Taxonomic identifieri7176 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex
ProteomesiUP000002320 Componenti: Partially assembled WGS sequence

Subcellular locationi

  • Cell junctionsynapse By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258F-box/SPRY domain-containing protein 1PRO_0000383309Add
BLAST

Interactioni

Subunit structurei

Component of an E3 ubiquitin ligase complex composed of hiw and Fsn.By similarity

Protein-protein interaction databases

STRINGi7176.CPIJ016123-PA.

Structurei

3D structure databases

ProteinModelPortaliB0X9V1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 5449F-boxPROSITE-ProRule annotationAdd
BLAST
Domaini64 – 256193B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FBXO45/Fsn family.Curated
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG263387.
HOGENOMiHOG000230524.
InParanoidiB0X9V1.
KOiK10319.
OMAiDENSDVW.
OrthoDBiEOG7QZGBV.
PhylomeDBiB0X9V1.

Family and domain databases

InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR001810. F-box_dom.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0X9V1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDDLTEYAP DIPDNVLELI FSYLKLQDLR NCALVCKSWH RFLSDENNEV
60 70 80 90 100
WRAQCMQKLS PDAFKTDLLS VVPTYKAKLR AFFHAWNPYD CSRHVYIKPN
110 120 130 140 150
GFTLHRNPVA QSTDGSRGKI GFQHGRHAWE VRWEGPLGTV AVVGIATKDA
160 170 180 190 200
AIQCHGYYAL LGADDQSWGW NLVDNLLLHN GDAHGIYPLL NNAPKYKVGE
210 220 230 240 250
RIRVILDCDD NTLSFEKNYE FLGVAFTDLP DKVFYPTVAA VYGNTEISMV

YLGPPLDG
Length:258
Mass (Da):29,186
Last modified:April 8, 2008 - v1
Checksum:i6C48CF803C93BF6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS232551 Genomic DNA. Translation: EDS43303.1.
RefSeqiXP_001866423.1. XM_001866388.1.

Genome annotation databases

EnsemblMetazoaiCPIJ016123-RA; CPIJ016123-PA; CPIJ016123.
GeneIDi6049704.
KEGGicqu:CpipJ_CPIJ016123.
VectorBaseiCPIJ016123. Culex quinquefasciatus.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS232551 Genomic DNA. Translation: EDS43303.1.
RefSeqiXP_001866423.1. XM_001866388.1.

3D structure databases

ProteinModelPortaliB0X9V1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7176.CPIJ016123-PA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCPIJ016123-RA; CPIJ016123-PA; CPIJ016123.
GeneIDi6049704.
KEGGicqu:CpipJ_CPIJ016123.
VectorBaseiCPIJ016123. Culex quinquefasciatus.

Phylogenomic databases

eggNOGiNOG263387.
HOGENOMiHOG000230524.
InParanoidiB0X9V1.
KOiK10319.
OMAiDENSDVW.
OrthoDBiEOG7QZGBV.
PhylomeDBiB0X9V1.

Enzyme and pathway databases

UniPathwayiUPA00143.

Family and domain databases

InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR001810. F-box_dom.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JHBImported.

Entry informationi

Entry nameiFBSP1_CULQU
AccessioniPrimary (citable) accession number: B0X9V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: April 8, 2008
Last modified: May 27, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.