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B0X9V1

- FBSP1_CULQU

UniProt

B0X9V1 - FBSP1_CULQU

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Protein

F-box/SPRY domain-containing protein 1

Gene

Fsn

Organism
Culex quinquefasciatus (Southern house mosquito) (Culex pungens)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromuscular junction (NMJ).By similarity

Pathwayi

GO - Biological processi

  1. negative regulation of synaptic growth at neuromuscular junction Source: UniProtKB
  2. nervous system development Source: UniProtKB-KW
  3. neuromuscular synaptic transmission Source: UniProtKB
  4. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Neurogenesis, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/SPRY domain-containing protein 1By similarity
Gene namesi
Name:FsnBy similarity
ORF Names:CPIJ016123
OrganismiCulex quinquefasciatus (Southern house mosquito) (Culex pungens)
Taxonomic identifieri7176 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex
ProteomesiUP000002320: Partially assembled WGS sequence

Subcellular locationi

Cell junctionsynapse By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. neuromuscular junction Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258F-box/SPRY domain-containing protein 1PRO_0000383309Add
BLAST

Interactioni

Subunit structurei

Component of an E3 ubiquitin ligase complex composed of hiw and Fsn.By similarity

Protein-protein interaction databases

STRINGi7176.CPIJ016123-PA.

Structurei

3D structure databases

ProteinModelPortaliB0X9V1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 5449F-boxPROSITE-ProRule annotationAdd
BLAST
Domaini64 – 256193B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FBXO45/Fsn family.Curated
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG263387.
HOGENOMiHOG000230524.
InParanoidiB0X9V1.
KOiK10319.
OMAiILDCDDN.
OrthoDBiEOG7QZGBV.
PhylomeDBiB0X9V1.

Family and domain databases

InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR001810. F-box_dom.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0X9V1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDDDLTEYAP DIPDNVLELI FSYLKLQDLR NCALVCKSWH RFLSDENNEV
60 70 80 90 100
WRAQCMQKLS PDAFKTDLLS VVPTYKAKLR AFFHAWNPYD CSRHVYIKPN
110 120 130 140 150
GFTLHRNPVA QSTDGSRGKI GFQHGRHAWE VRWEGPLGTV AVVGIATKDA
160 170 180 190 200
AIQCHGYYAL LGADDQSWGW NLVDNLLLHN GDAHGIYPLL NNAPKYKVGE
210 220 230 240 250
RIRVILDCDD NTLSFEKNYE FLGVAFTDLP DKVFYPTVAA VYGNTEISMV

YLGPPLDG
Length:258
Mass (Da):29,186
Last modified:April 8, 2008 - v1
Checksum:i6C48CF803C93BF6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS232551 Genomic DNA. Translation: EDS43303.1.
RefSeqiXP_001866423.1. XM_001866388.1.

Genome annotation databases

EnsemblMetazoaiCPIJ016123-RA; CPIJ016123-PA; CPIJ016123.
GeneIDi6049704.
KEGGicqu:CpipJ_CPIJ016123.
VectorBaseiCPIJ016123. Culex quinquefasciatus.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS232551 Genomic DNA. Translation: EDS43303.1 .
RefSeqi XP_001866423.1. XM_001866388.1.

3D structure databases

ProteinModelPortali B0X9V1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7176.CPIJ016123-PA.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CPIJ016123-RA ; CPIJ016123-PA ; CPIJ016123 .
GeneIDi 6049704.
KEGGi cqu:CpipJ_CPIJ016123.
VectorBasei CPIJ016123. Culex quinquefasciatus.

Phylogenomic databases

eggNOGi NOG263387.
HOGENOMi HOG000230524.
InParanoidi B0X9V1.
KOi K10319.
OMAi ILDCDDN.
OrthoDBi EOG7QZGBV.
PhylomeDBi B0X9V1.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Family and domain databases

InterProi IPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR001810. F-box_dom.
IPR003877. SPRY_dom.
[Graphical view ]
Pfami PF12937. F-box-like. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view ]
SMARTi SM00256. FBOX. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JHBImported.

Entry informationi

Entry nameiFBSP1_CULQU
AccessioniPrimary (citable) accession number: B0X9V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3