Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone deacetylase

Gene

6046349

Organism
Culex quinquefasciatus (Southern house mosquito) (Culex pungens)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei94SubstrateUniRule annotation1
Active sitei136Proton acceptorUniRule annotation1
Binding sitei144Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi171Divalent metal cationUniRule annotation1
Metal bindingi173Divalent metal cationUniRule annotation1
Metal bindingi260Divalent metal cationUniRule annotation1
Binding sitei299SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
Name:6046349Imported
ORF Names:CpipJ_CPIJ013384Imported
OrganismiCulex quinquefasciatus (Southern house mosquito) (Culex pungens)Imported
Taxonomic identifieri7176 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex
Proteomesi
  • UP000002320 Componenti: Partially assembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi7176.CPIJ013384-PA.

Structurei

3D structure databases

ProteinModelPortaliB0X1P4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 314Hist_deacetylInterPro annotationAdd BLAST292

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
HOGENOMiHOG000225180.
InParanoidiB0X1P4.
KOiK11404.
OMAiPRAWTHL.
OrthoDBiEOG091G067J.
PhylomeDBiB0X1P4.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
IPR037138. His_deacetylse_dom_sf.
IPR023696. Ureohydrolase_domain.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
SUPFAMiSSF52768. SSF52768. 1 hit.

Sequencei

Sequence statusi: Complete.

B0X1P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTKKVSYFF NPDVGNFHYG PGHPMKPHRL SVIHHLVMNY GLHKKMQIYR
60 70 80 90 100
PYKASAHDMC RFHSDEYIDF LQRVTPQNIQ GYTKCLSTFN VGDDCPVFDG
110 120 130 140 150
LFEFCAMYTG ASLEGAQKLN HNHSDICINW SGGLHHAKKF EASGFCYVND
160 170 180 190 200
IVIGILELLK YHPRVLYIDI DVHHGDGVQE AFYLTDRVMT VSFHKYGNYF
210 220 230 240 250
FPGTGDMYEI GAESGRYYSV NVPLKEGIDD QSYVATFKPV ITYVMDFYKP
260 270 280 290 300
TAIVLQCGAD SLAGDRLGCF SLSTKGHGEC VKFVKDLNVP TLVVGGGGYT
310 320 330 340 350
LRNVARCWTY ETSLLIDETI SNELPMNDYL EFFAPDFTLH PDIPSRQDNA
360 370 380 390 400
NSKQYLEAIT KHVYDNLKMC QHAPSVQMFH IPEDALPEEV KVKEEPNPEA
410 420 430
RMTQEEEDKH VEPKNEFFDG ENDNDKSEND P
Length:431
Mass (Da):49,048
Last modified:April 8, 2008 - v1
Checksum:iF6FBB3424DC74735
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS232266 Genomic DNA. Translation: EDS38772.1.
RefSeqiXP_001863566.1. XM_001863531.1.
UniGeneiCpi.8957.

Genome annotation databases

EnsemblMetazoaiCPIJ013384-RA; CPIJ013384-PA; CPIJ013384.
GeneIDi6046349.
KEGGicqu:CpipJ_CPIJ013384.
VectorBaseiCPIJ013384-RA; CPIJ013384-PA; CPIJ013384.

Similar proteinsi

Entry informationi

Entry nameiB0X1P4_CULQU
AccessioniPrimary (citable) accession number: B0X1P4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: October 25, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported