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Protein

Moesin/ezrin/radixin homolog 1

Gene

Moe

Organism
Culex quinquefasciatus (Southern house mosquito) (Culex pungens)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in connections of major cytoskeletal structures to the plasma membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Moesin/ezrin/radixin homolog 1By similarity
Gene namesi
Name:MoeBy similarity
ORF Names:CPIJ012259
OrganismiCulex quinquefasciatus (Southern house mosquito) (Culex pungens)
Taxonomic identifieri7176 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex
Proteomesi
  • UP000002320 Componenti: Partially assembled WGS sequence

Subcellular locationi

  • Cell junctionadherens junction By similarity
  • Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
  • Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Moesin/ezrin/radixin homolog 1PRO_0000355094Add
BLAST

Proteomic databases

PRIDEiB0WYY2.

Interactioni

Subunit structurei

Interacts with cytoskeletal actin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7176.CPIJ012259-PA.

Structurei

3D structure databases

ProteinModelPortaliB0WYY2.
SMRiB0WYY2. Positions 1-572.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 291291FERMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi307 – 480174Glu-richSequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3529. Eukaryota.
ENOG410XQFP. LUCA.
HOGENOMiHOG000007113.
InParanoidiB0WYY2.
OMAiHELYIAR.
OrthoDBiEOG7BGHK6.
PhylomeDBiB0WYY2.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR011174. ERM.
IPR011259. ERM_C_dom.
IPR000798. Ez/rad/moesin-like.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR008954. Moesin_tail.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00769. ERM. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PIRSFiPIRSF002305. ERM. 1 hit.
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF48678. SSF48678. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0WYY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVRVTTMDA ELEFAIQQST TGKQLFDQVV KTIGLREVWF FGLQYTDSKG
60 70 80 90 100
DLTWIKLYKK VMSQDVQKGD PLQFKFRAKF YPEDVAEELI QDITLRLFYL
110 120 130 140 150
QVKNAILSDE IYCPPETSVL LASYAVQARH GDYNKTTHTP GFLVNDRLLP
160 170 180 190 200
QRVIDQHKMS KDEWENSITT WWQEHRGMLR EDAMMEYLKI AQDLEMYGVN
210 220 230 240 250
YFEIRNKKGT ELWLGVDALG LNIYEKDDRL TPKIGFPWSE IRNISFNDRK
260 270 280 290 300
FIIKPIDKKA PDFVFFAPRV RINKRILALC MGNHELYMRR RKPDTIDVQQ
310 320 330 340 350
MKAQAREEKN AKQQEREKLQ LALAARERAE KKQQEYEDRI RNMQEEMERS
360 370 380 390 400
QANLIEAQDM IRRLEEQLKQ LQAAKDDLEQ RQNELQVMIT RLEETKNMEA
410 420 430 440 450
AERAKLEDEI RMKQEEVHKI QEEVSVKDSE TKRLQEEVEE ARRKQTEAAA
460 470 480 490 500
ALLAATTTPS HHHVEEEEEM DNEEELVNGE NGNQDFSKDF DTDEHIKDPV
510 520 530 540 550
EERRTLAERN ERLHDQLKAL KQDLALSRDD TMETANDKIH RENVRQGRDK
560 570
YKTLREIRKG NTKRRVDQFE NM
Length:572
Mass (Da):67,748
Last modified:April 8, 2008 - v1
Checksum:iC677CBEE39EA0085
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS232201 Genomic DNA. Translation: EDS37245.1.
RefSeqiXP_001862607.1. XM_001862572.1.
UniGeneiCpi.3387.

Genome annotation databases

EnsemblMetazoaiCPIJ012259-RA; CPIJ012259-PA; CPIJ012259.
GeneIDi6045211.
KEGGicqu:CpipJ_CPIJ012259.
VectorBaseiCPIJ012259. Culex quinquefasciatus.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS232201 Genomic DNA. Translation: EDS37245.1.
RefSeqiXP_001862607.1. XM_001862572.1.
UniGeneiCpi.3387.

3D structure databases

ProteinModelPortaliB0WYY2.
SMRiB0WYY2. Positions 1-572.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7176.CPIJ012259-PA.

Proteomic databases

PRIDEiB0WYY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCPIJ012259-RA; CPIJ012259-PA; CPIJ012259.
GeneIDi6045211.
KEGGicqu:CpipJ_CPIJ012259.
VectorBaseiCPIJ012259. Culex quinquefasciatus.

Phylogenomic databases

eggNOGiKOG3529. Eukaryota.
ENOG410XQFP. LUCA.
HOGENOMiHOG000007113.
InParanoidiB0WYY2.
OMAiHELYIAR.
OrthoDBiEOG7BGHK6.
PhylomeDBiB0WYY2.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR011174. ERM.
IPR011259. ERM_C_dom.
IPR000798. Ez/rad/moesin-like.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR008954. Moesin_tail.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00769. ERM. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PIRSFiPIRSF002305. ERM. 1 hit.
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF48678. SSF48678. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JHBImported.

Entry informationi

Entry nameiMOEH_CULQU
AccessioniPrimary (citable) accession number: B0WYY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: April 8, 2008
Last modified: May 11, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.