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B0WSB8

- TRMB_CULQU

UniProt

B0WSB8 - TRMB_CULQU

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

CPIJ009694

Organism
Culex quinquefasciatus (Southern house mosquito) (Culex pungens)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei64 – 641S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei140 – 1401S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Active sitei143 – 1431UniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
  2. tRNA binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine, tRNA-binding

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
ORF Names:CPIJ009694
OrganismiCulex quinquefasciatus (Southern house mosquito) (Culex pungens)
Taxonomic identifieri7176 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex
ProteomesiUP000002320: Partially assembled WGS sequence

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239tRNA (guanine-N(7)-)-methyltransferasePRO_0000370567Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7176.CPIJ009694-PA.

Structurei

3D structure databases

ProteinModelPortaliB0WSB8.
SMRiB0WSB8. Positions 37-239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni87 – 882S-adenosyl-L-methionine bindingUniRule annotation
Regioni120 – 1212S-adenosyl-L-methionine bindingUniRule annotation
Regioni218 – 2203S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000260965.
InParanoidiB0WSB8.
KOiK03439.
OMAiRAHSNPI.
OrthoDBiEOG7PS1GC.
PhylomeDBiB0WSB8.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0WSB8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEVDSKKSSD VVTKLPQKRF YRQRAHSNPI ADHSFQYPAH PDEYEWSQHY
60 70 80 90 100
PDIGDRRVAF ADIGCGYGGF LVTLGEIYPD KFAVGMEIRV KVSDYVMDRI
110 120 130 140 150
DALRKLHEGQ YRNVACIRTN AMKYLTNFFH KAQLEKMFFL YPDPHFKKAK
160 170 180 190 200
HKWRIINSAL LSEYSYVLRK GGLIYTVTDV RDLHEWMCKH IEQHPAFERL
210 220 230
SEAEVEADIL SEKLLDSSEE GKKVTRNKGD KFVAIFRRV
Length:239
Mass (Da):27,999
Last modified:April 8, 2008 - v1
Checksum:i56ED500166BECCC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS232068 Genomic DNA. Translation: EDS33756.1.
RefSeqiXP_001851677.1. XM_001851626.1.
UniGeneiCpi.5362.

Genome annotation databases

EnsemblMetazoaiCPIJ009694-RA; CPIJ009694-PA; CPIJ009694.
GeneIDi6042495.
KEGGicqu:CpipJ_CPIJ009694.
VectorBaseiCPIJ009694. Culex quinquefasciatus.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS232068 Genomic DNA. Translation: EDS33756.1 .
RefSeqi XP_001851677.1. XM_001851626.1.
UniGenei Cpi.5362.

3D structure databases

ProteinModelPortali B0WSB8.
SMRi B0WSB8. Positions 37-239.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7176.CPIJ009694-PA.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CPIJ009694-RA ; CPIJ009694-PA ; CPIJ009694 .
GeneIDi 6042495.
KEGGi cqu:CpipJ_CPIJ009694.
VectorBasei CPIJ009694. Culex quinquefasciatus.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000260965.
InParanoidi B0WSB8.
KOi K03439.
OMAi RAHSNPI.
OrthoDBi EOG7PS1GC.
PhylomeDBi B0WSB8.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JHB.

Entry informationi

Entry nameiTRMB_CULQU
AccessioniPrimary (citable) accession number: B0WSB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3