ID   B0WRG8_CULQU            Unreviewed;       694 AA.
AC   B0WRG8;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 85.
DE   RecName: Full=DNA ligase ATP-dependent N-terminal domain-containing protein {ECO:0000259|Pfam:PF04675};
GN   Name=6042154 {ECO:0000313|EnsemblMetazoa:CPIJ009862-PA};
GN   ORFNames=CpipJ_CPIJ009862 {ECO:0000313|EMBL:EDS33361.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1] {ECO:0000313|EMBL:EDS33361.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS33361.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:CPIJ009862-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ009862-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   EMBL; DS232055; EDS33361.1; -; Genomic_DNA.
DR   RefSeq; XP_001851302.1; XM_001851250.1.
DR   AlphaFoldDB; B0WRG8; -.
DR   STRING; 7176.B0WRG8; -.
DR   EnsemblMetazoa; CPIJ009862-RA; CPIJ009862-PA; CPIJ009862.
DR   KEGG; cqu:CpipJ_CPIJ009862; -.
DR   VEuPathDB; VectorBase:CPIJ009862; -.
DR   VEuPathDB; VectorBase:CQUJHB005709; -.
DR   VEuPathDB; VectorBase:CQUJHB010101; -.
DR   eggNOG; KOG0967; Eukaryota.
DR   HOGENOM; CLU_397035_0_0_1; -.
DR   InParanoid; B0WRG8; -.
DR   OrthoDB; 961at2759; -.
DR   Proteomes; UP000002320; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3260.10; DNA ligase, ATP-dependent, N-terminal domain; 1.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   PANTHER; PTHR45674:SF4; DNA LIGASE 1; 1.
DR   PANTHER; PTHR45674; DNA LIGASE 1/3 FAMILY MEMBER; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SUPFAM; SSF117018; ATP-dependent DNA ligase DNA-binding domain; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT   DOMAIN          417..535
FT                   /note="DNA ligase ATP-dependent N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04675"
FT   REGION          308..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          360..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        309..325
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   694 AA;  76879 MW;  1C93BC96976F3F2D CRC64;
     MSRVEQARAV VRLARSKVFP TAVEVQPGLR SLLVLLLSHL WMHYGHCYSM EVLQSVETAA
     VVATAAATDY DANFPKLYDA LELTGDDTAA PRINAPAVPC DPPGPCPRPR PLRLTTPDSG
     ALHQPHRDRH DSGHHFRRLQ HHHLSSSQEF EQVLVRLRIC VKVVVDLRLQ LLGDDRSSGQ
     QHLLYQLLFH YFPISCDTVL LFNFLFAAVP PKTTKTNTRD VKRSYQCDVK REFLSHKNSV
     GTRLLLVPLQ MTKSFSYAGC KRSPNSNTVS SDSSRTNSCL LWKVVCFCFF VTSVVCSAGK
     KPKLVASSTE ESAAGTPSSV KKSPSDSIPG GGKKCIESPD PDRVHGSFKS AKKKTFTVVK
     KEVKREPSES PKRREGGCGE SGRLQELRDG VQYGRKFWPN GETVTCLART LQIIEWLRMI
     EILANYFCSV ILILSPDDLL LEPACLAPAY AGVELDMTGV LVDDAIRQST GRSLAQILMD
     AQTTRDLGLV AEQSKSSYRM MFRPAPHAVN DVFGKLRKIN KMTGTDDGQD SVDVWAASVR
     KLSKAKVEDI ALVLKTESVN QIVQLLLEDG VVHLVDKCSM MPGTPLKFML AHPTKGVQEV
     LERFGGRQRE HLQLELGEQH EHVPGSLPGL TALGRVQEYI PGLRNIVGVE QISYPPTIKT
     TWWKHHPPVP DAEKLQDHLI KARSPGSSAG DTKD
//