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Protein
Submitted name:

Angiotensin-converting enzyme

Gene

CpipJ_CPIJ009108

Organism
Culex quinquefasciatus (Southern house mosquito) (Culex pungens)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

GO - Molecular functioni

  1. carboxypeptidase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. metallopeptidase activity Source: UniProtKB-KW
  4. peptidyl-dipeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

CarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Protein family/group databases

MEROPSiM02.003.

Names & Taxonomyi

Protein namesi
Submitted name:
Angiotensin-converting enzymeImported
Gene namesi
ORF Names:CpipJ_CPIJ009108Imported
OrganismiCulex quinquefasciatus (Southern house mosquito) (Culex pungens)Imported
Taxonomic identifieri7176 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex
ProteomesiUP000002320: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

GlycoproteinUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7176.CPIJ009108-PA.

Structurei

3D structure databases

ProteinModelPortaliB0WR91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M2 family.UniRule annotation

Phylogenomic databases

eggNOGiNOG71044.
HOGENOMiHOG000046399.
InParanoidiB0WR91.
KOiK01283.
OMAiAHVQYFL.
OrthoDBiEOG76HQ13.
PhylomeDBiB0WR91.

Family and domain databases

InterProiIPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF01401. Peptidase_M2. 1 hit.
[Graphical view]
PRINTSiPR00791. PEPDIPTASEA.

Sequencei

Sequence statusi: Complete.

B0WR91-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSETLLRVAL LLQVIISTHG EADPQLNIPA GQINRDLQGR PQVLPNSYTG
60 70 80 90 100
ERSGQHRDRD DLQDGEEGDT KKAGNDFDHS RSERFGPPYD DRDDEEENYP
110 120 130 140 150
EGRSNDDQRD RQDRPNRPFS YDDRNRYNNY NDDDRNNFDR NRNPYDRDRD
160 170 180 190 200
RDRGQYPYNR DRNRYVSDVD NPDLYQNRAP YNPNQDGRYN PENGRYDPND
210 220 230 240 250
RRRPIQNDVD NPNLYQDRTP YNPNGPQTNG RFDPNRRPQF GPVDQFDNGR
260 270 280 290 300
PRDSFNPGSF RSVEEERRFR AETEKLKTFL ADIDRKSSLE CSLNVAAQWN
310 320 330 340 350
FETNVNDATQ VEAIAAQQRY NDFQRLLWDQ MRHIDQSKIF DDKLYRQVRL
360 370 380 390 400
MSIIGPSALP PDQLDRYNRI VNDMLAIFNG AQICAFERPF ECGLRLQPHL
410 420 430 440 450
KDIMAKSRDW NELTWTWVEY RRKTGRNMRE LFEQLVDLTN DAARVNNFTN
460 470 480 490 500
AAQYWQFPYE SRNFREEMEQ VWNEILPLYE MLHAYVRRKL REFYGPDKIN
510 520 530 540 550
KNAPIPDHIL GDMYGQSWNN ILDILIPYPG RSFLEVTPEM QKQGYNPLVM
560 570 580 590 600
FQIAEEFFVS MNMSALPPDF WLTSIFTQPP DRPVLCQPSA WDFCTGKDYR
610 620 630 640 650
IKMCTSVTHK DLITVHHELA HVQYFLNYRN NPKVFRDGAN PGFHEAIGDA
660 670 680 690 700
VTLSVANPKH LQNLGLVQKN VDDTAHDINF LFSLALEKVV FLPYALALDA
710 720 730 740 750
WRYDVFNKKV RKEQYNCHWV LLREQFGGLK PPVLRSELDF DPGAKYHVAA

NIPYIK
Length:756
Mass (Da):89,021
Last modified:April 8, 2008 - v1
Checksum:i36AF1D168F79318A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS232053 Genomic DNA. Translation: EDS33275.1.
RefSeqiXP_001851225.1. XM_001851173.1.

Genome annotation databases

EnsemblMetazoaiCPIJ009108-RA; CPIJ009108-PA; CPIJ009108.
GeneIDi6042071.
KEGGicqu:CpipJ_CPIJ009108.
VectorBaseiCPIJ009108. Culex quinquefasciatus.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS232053 Genomic DNA. Translation: EDS33275.1.
RefSeqiXP_001851225.1. XM_001851173.1.

3D structure databases

ProteinModelPortaliB0WR91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7176.CPIJ009108-PA.

Protein family/group databases

MEROPSiM02.003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCPIJ009108-RA; CPIJ009108-PA; CPIJ009108.
GeneIDi6042071.
KEGGicqu:CpipJ_CPIJ009108.
VectorBaseiCPIJ009108. Culex quinquefasciatus.

Phylogenomic databases

eggNOGiNOG71044.
HOGENOMiHOG000046399.
InParanoidiB0WR91.
KOiK01283.
OMAiAHVQYFL.
OrthoDBiEOG76HQ13.
PhylomeDBiB0WR91.

Family and domain databases

InterProiIPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF01401. Peptidase_M2. 1 hit.
[Graphical view]
PRINTSiPR00791. PEPDIPTASEA.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JHBImported.

Entry informationi

Entry nameiB0WR91_CULQU
AccessioniPrimary (citable) accession number: B0WR91
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: January 7, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.