ID   B0WR90_CULQU            Unreviewed;       621 AA.
AC   B0WR90;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 85.
DE   RecName: Full=Angiotensin-converting enzyme {ECO:0000256|RuleBase:RU361144};
DE            EC=3.4.-.- {ECO:0000256|RuleBase:RU361144};
GN   Name=6042070 {ECO:0000313|EnsemblMetazoa:CPIJ009107-PA};
GN   ORFNames=CpipJ_CPIJ009107 {ECO:0000313|EMBL:EDS33274.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1] {ECO:0000313|EMBL:EDS33274.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS33274.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:CPIJ009107-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ009107-PA};
RG   EnsemblMetazoa;
RL   Submitted (FEB-2021) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361144};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361144};
CC   -!- SIMILARITY: Belongs to the peptidase M2 family.
CC       {ECO:0000256|ARBA:ARBA00008139, ECO:0000256|RuleBase:RU361144}.
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DR   EMBL; DS232053; EDS33274.1; -; Genomic_DNA.
DR   RefSeq; XP_001851224.1; XM_001851172.1.
DR   AlphaFoldDB; B0WR90; -.
DR   MEROPS; M02.003; -.
DR   EnsemblMetazoa; CPIJ009107-RA; CPIJ009107-PA; CPIJ009107.
DR   KEGG; cqu:CpipJ_CPIJ009107; -.
DR   VEuPathDB; VectorBase:CPIJ009107; -.
DR   VEuPathDB; VectorBase:CQUJHB000776; -.
DR   eggNOG; KOG3690; Eukaryota.
DR   HOGENOM; CLU_014364_3_3_1; -.
DR   InParanoid; B0WR90; -.
DR   OMA; QEWWNFR; -.
DR   OrthoDB; 2898149at2759; -.
DR   Proteomes; UP000002320; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008241; F:peptidyl-dipeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd06461; M2_ACE; 1.
DR   InterPro; IPR001548; Peptidase_M2.
DR   PANTHER; PTHR10514; ANGIOTENSIN-CONVERTING ENZYME; 1.
DR   PANTHER; PTHR10514:SF27; ANGIOTENSIN-CONVERTING ENZYME; 1.
DR   Pfam; PF01401; Peptidase_M2; 1.
DR   PRINTS; PR00791; PEPDIPTASEA.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|RuleBase:RU361144};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180,
KW   ECO:0000256|RuleBase:RU361144}; Hydrolase {ECO:0000256|RuleBase:RU361144};
KW   Metal-binding {ECO:0000256|RuleBase:RU361144};
KW   Metalloprotease {ECO:0000256|RuleBase:RU361144};
KW   Protease {ECO:0000256|RuleBase:RU361144};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Zinc {ECO:0000256|RuleBase:RU361144}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..621
FT                   /note="Angiotensin-converting enzyme"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5011408410"
SQ   SEQUENCE   621 AA;  71713 MW;  FFDAD2C6E414D065 CRC64;
     MVTKVLVLAL LASVALAVNP DLEDQELAGQ KYVSDLEADI LARNNEATEA SWAYESDISE
     AHLKARDEIQ VRNANYFKEV ARELRKYDWQ NFKNGDLKRM FKKMTDLGYA ALPEAKFTEL
     LDAISSMSEN YATAKVCDYK NREKCDLALE PELTEIFATS RDPEELKYYW TQWYDKAGTP
     TREAFDKYIK LSNEAAKLNN LSSGAEAWLD AYEDETFEQQ ADAAIEQIRP LYEQIHAYVR
     HKLRERYGED VVSEKGPIPM HLLGNMWAQS WDNVADFTTP YPNSQLMDVT EEMVKQGYSA
     KQMFEMGDDF FVSLNMTRLP QSFWEKSILE KPTDGRELVC HASAWDFYKT DDVRIKQCTR
     INMEDFFTAH HELGHIQYFL QYQHQPSTYR EGANPGFHEA VGDVISLSVS TPKHLEKIGL
     LKDFVMDEEA KMNQFYRQGL SKLVFLPFAY TLDKYRYGMF RGEIKPDQAN CKFWEMRTKF
     SGIEPPVVRS EKDFDGPAKY HMSADVEYLR YLVSFIIQFQ FHRSACELAG EYVKGDPVKT
     LNNCDIYQNA NAGNAIKEML ALGSSKPWPD AMEVLTGQRT MSADALLEYF QPLQDWLVVE
     NKRLGAYVGW EKSDKTLLLD R
//