ID   B0WNN4_CULQU            Unreviewed;       920 AA.
AC   B0WNN4;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 87.
DE   SubName: Full=Lactase-phlorizin hydrolase {ECO:0000313|EMBL:EDS31870.1};
GN   Name=6041003 {ECO:0000313|EnsemblMetazoa:CPIJ008529-PA};
GN   ORFNames=CpipJ_CPIJ008529 {ECO:0000313|EMBL:EDS31870.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1] {ECO:0000313|EMBL:EDS31870.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS31870.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:CPIJ008529-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ008529-PA};
RG   EnsemblMetazoa;
RL   Submitted (FEB-2021) to UniProtKB.
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DR   EMBL; DS232013; EDS31870.1; -; Genomic_DNA.
DR   RefSeq; XP_001850318.1; XM_001850266.1.
DR   AlphaFoldDB; B0WNN4; -.
DR   STRING; 7176.B0WNN4; -.
DR   EnsemblMetazoa; CPIJ008529-RA; CPIJ008529-PA; CPIJ008529.
DR   KEGG; cqu:CpipJ_CPIJ008529; -.
DR   VEuPathDB; VectorBase:CPIJ008529; -.
DR   VEuPathDB; VectorBase:CQUJHB003043; -.
DR   VEuPathDB; VectorBase:CQUJHB006400; -.
DR   eggNOG; KOG0626; Eukaryota.
DR   HOGENOM; CLU_001859_5_2_1; -.
DR   InParanoid; B0WNN4; -.
DR   OMA; MGGWANP; -.
DR   OrthoDB; 3373839at2759; -.
DR   Proteomes; UP000002320; Unassembled WGS sequence.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.80; Glycosidases; 3.
DR   InterPro; IPR001360; Glyco_hydro_1.
DR   InterPro; IPR018120; Glyco_hydro_1_AS.
DR   InterPro; IPR033132; Glyco_hydro_1_N_CS.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR10353; GLYCOSYL HYDROLASE; 1.
DR   PANTHER; PTHR10353:SF36; KLOTHO (MAMMALIAN AGING-ASSOCIATED PROTEIN) HOMOLOG; 1.
DR   Pfam; PF00232; Glyco_hydro_1; 2.
DR   PRINTS; PR00131; GLHYDRLASE1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 2.
DR   PROSITE; PS00572; GLYCOSYL_HYDROL_F1_1; 2.
DR   PROSITE; PS00653; GLYCOSYL_HYDROL_F1_2; 1.
PE   4: Predicted;
KW   Glycosidase {ECO:0000256|RuleBase:RU004468};
KW   Hydrolase {ECO:0000256|RuleBase:RU004468, ECO:0000313|EMBL:EDS31870.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   ACT_SITE        317
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10055"
FT   ACT_SITE        793
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10055"
SQ   SEQUENCE   920 AA;  105697 MW;  6AB8557E22783A21 CRC64;
     MYRFSLSWTR IMPSGISNNV NQAGIDYYNK LINELLKYNI EPMITLYHWD LPQRLQEIGG
     WTNREVVGHF REYARVVFEA FGDRVKWWTT FNEPSQTCMF SYEYDAMAPG YEFPGIPCYL
     CTHNVLLAHA EAVELYRKQF NTKQEGMTKF DIEDYKGIIG ITVDSSWSAP RSDSAEDLEA
     SELSLQFHLG WYMHPIYSKT GNYPQVMIDR INALSKEQGF ANSRLPVFTE EEIEKLKGSS
     DFFGINTYTT SIVYKNDNNT ANFRVPSFDH DRNTLGYQDP SWPSSGSGWL KVYPKGLYYL
     LNWIREEYDS PPIYVTENGV SDLGGTKDVA RVEYYNSYLE AVLDAMEDGC DVRGYVAWSL
     MDNFEWRAGL TERFGMYYVD YEDSKRTRIA KSSAKVFANI IKTRTIDPDY LPEPDLLIPG
     PTENPSFLRI LAAANGQKKF PPGFKFGVGT SAYQIEGAWN VDGKGESIWD HLTHNYPDKI
     ADRTNGDIAC DSYHNWQRDV QMLKELGVNM YRFSIAWSRI MPTGFSNNIN QAGIDYYNKL
     INELIKNNIE PMVTLYHWDL PQRLQEIGGW TNREIVDHFR EYARVAFNAF GDRVKWWTTF
     NEPLQTCMFS YEYDSMAPGL EESRYTMLSI AGIIGITVDS SWAEPRSESA DDREASELAM
     QFHIGWYMHP IFSKTGNYPQ VMINRINALS QQQGFASSRL PVFTPAEIEK LKGSSDFFGI
     NTYTTSIVYK NDAQNSGNFR IPSFDHDRNT IGYQDPTWPG SGSGWLKVYP KGMHQLLNWI
     RNEYDNPPVY VTENGVSDRG GTKDVARVNY YNQYLGAVLD AMAEGSDVRG YVAWSLMDNF
     EWRAGLTERF GLFYVDYEDP TRKRSAKTSA KVLAKIIETR EIDLEYLPEP EVFIPQPGAA
     MSVLVSRMLM MLSHIFGTLL
//