ID   EIF3E_CULQU             Reviewed;         435 AA.
AC   B0WAM5;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 76.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit E {ECO:0000255|HAMAP-Rule:MF_03004};
DE            Short=eIF3e {ECO:0000255|HAMAP-Rule:MF_03004};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 6 {ECO:0000255|HAMAP-Rule:MF_03004};
GN   Name=eIF3-S6; ORFNames=CPIJ003936;
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB;
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03004}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03004}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03004}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit E family. {ECO:0000255|HAMAP-
CC       Rule:MF_03004}.
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DR   EMBL; DS231873; EDS41579.1; -; Genomic_DNA.
DR   RefSeq; XP_001845759.1; XM_001845707.1.
DR   AlphaFoldDB; B0WAM5; -.
DR   SMR; B0WAM5; -.
DR   STRING; 7176.B0WAM5; -.
DR   EnsemblMetazoa; CPIJ003936-RA; CPIJ003936-PA; CPIJ003936.
DR   EnsemblMetazoa; XM_001845707.2; XP_001845759.1; LOC6035610.
DR   GeneID; 6035610; -.
DR   KEGG; cqu:CpipJ_CPIJ003936; -.
DR   VEuPathDB; VectorBase:CPIJ003936; -.
DR   VEuPathDB; VectorBase:CQUJHB002753; -.
DR   eggNOG; KOG2758; Eukaryota.
DR   HOGENOM; CLU_031132_0_1_1; -.
DR   InParanoid; B0WAM5; -.
DR   OMA; TIQTNCP; -.
DR   OrthoDB; 226348at2759; -.
DR   PhylomeDB; B0WAM5; -.
DR   Proteomes; UP000002320; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   CDD; cd21378; eIF3E; 1.
DR   HAMAP; MF_03004; eIF3e; 1.
DR   InterPro; IPR016650; eIF3e.
DR   InterPro; IPR019010; eIF3e_N.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10317; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E; 1.
DR   PANTHER; PTHR10317:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E; 1.
DR   Pfam; PF09440; eIF3_N; 1.
DR   Pfam; PF01399; PCI; 1.
DR   PIRSF; PIRSF016255; eIF3e_su6; 1.
DR   SMART; SM01186; eIF3_N; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..435
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   E"
FT                   /id="PRO_0000365962"
FT   DOMAIN          219..392
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   435 AA;  51173 MW;  35825B993A91A9E6 CRC64;
     MSKFDLTAKN CQYLDRHLTF PLLEFLLQKN IYDQTSLLKF ILETVSKTNM VDYTMDIRER
     LNMGNELPEE LTKRRSNVLV KLKELQTEVA PLMKCMEELK NPDTMKDSKS IVHALQQEFD
     FKYDIIRSAQ KLAKYLYECG NYRDSISYLY ICLLVMEPTD KNYLNVLWGK LAAEILTLNW
     PTALEDLTRL RDFIDNHNFS PIEVLQQRTW LIHWSVLVFF NHAKGRDLII EMFLYKQLYL
     NAIQTMCPHI LRYLATAVII NRGRRNALKD LIKIIQQESY TYKDPITEFL ECLYVNFDFE
     GARMKLHECQ TVIINDFFII GCLQEFIENA RLMIFETFCR IHQCITIGML ADKLNMEPDE
     AECWIVNLIR NARLDAKIDS KLGHVVMGTQ PLSPYQQLVE KIDSLSVRSE ALTVLVERKQ
     KAKTQESGEG NWKYY
//