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Protein
Submitted name:

Angiotensin-converting enzyme

Gene

CpipJ_CPIJ004086

Organism
Culex quinquefasciatus (Southern house mosquito) (Culex pungens)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

CarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Angiotensin-converting enzymeImported
Gene namesi
ORF Names:CpipJ_CPIJ004086Imported
OrganismiCulex quinquefasciatus (Southern house mosquito) (Culex pungens)Imported
Taxonomic identifieri7176 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex
Proteomesi
  • UP000002320 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500275895221 – 1229Sequence analysisAdd BLAST1209

Keywords - PTMi

GlycoproteinUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7176.CPIJ004086-PA.

Structurei

3D structure databases

ProteinModelPortaliB0WAI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili606 – 631Sequence analysisAdd BLAST26

Sequence similaritiesi

Belongs to the peptidase M2 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3690. Eukaryota.
ENOG410XPJ3. LUCA.
HOGENOMiHOG000007838.
InParanoidiB0WAI2.
KOiK01283.
OMAiVTMEQLF.
OrthoDBiEOG091G033S.
PhylomeDBiB0WAI2.

Family and domain databases

CDDicd06461. M2_ACE. 2 hits.
InterProiIPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF01401. Peptidase_M2. 2 hits.
[Graphical view]
PRINTSiPR00791. PEPDIPTASEA.

Sequencei

Sequence statusi: Complete.

B0WAI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNAIILLVS LAVFVQQLNA LPQQVVANDV LSEEEMIATL QAYDQEVRQH
60 70 80 90 100
CTRQVQANWN VATDTENKDY EVEQNAASLA YAAFRNDYYE RFFKDAPVEN
110 120 130 140 150
YKDEKIRKQL RLLKDLGTAA LPTSKLEDYN RVMRRMDGAY QLAEICPYDN
160 170 180 190 200
QQCSGDAAKW TLDPEMEHVL ATSNDYNELA YVWRRWREES GKKMRSDYKE
210 220 230 240 250
YVEYVNEAAK LNGYADYGEL WRSRYDDSDL RGTLDRLWKE VEPLYNELHT
260 270 280 290 300
YVRYKLLDRY ADHMDRDNKM IPAHILGNMW AQSWVNLYDR IKPFPEGSLV
310 320 330 340 350
DVTAKMKELG YNASVMFEMS DEFYQSMGLP SSAMSYGPKA VIEKLPHKMV
360 370 380 390 400
CHASAWDFCD GEDFRIKMCT NVNMEDFITV HHEMGHIMYY ILYKDQPQMF
410 420 430 440 450
RTGATPAFHE AVGDTIALSV STPKHLLKVG LLEEYADTEA DNINALFEMA
460 470 480 490 500
LERVAFLPFG YLIDLWRWDV FSGAVNESEW NNHWWILREK YQKVYAPVQR
510 520 530 540 550
SEEDFDPGAK YHIPANSQYI AYFLAHILEF QFYRSLCIEA GQYKPNDPTS
560 570 580 590 600
EPLHKCDFYN SKAAGDKLRE GLQLGYSEDW TLALEKLTGG REISGQALLE
610 620 630 640 650
YFAPLYEFLQ RENKKLKNAE MEEIIETYNQ QFSVACNKQV KAQYATQVDV
660 670 680 690 700
ENITLRLELT EILNENTRFV QENYNKYFVD INMEDYENKE VQRQLQYLTQ
710 720 730 740 750
ISINSLSSND FNALNTALGK MQDIYSRTVI CPFGKPECTE GQLSLDPHLY
760 770 780 790 800
EIMAKSENYD ELLYVWKEWR DKTGRLMKDD YNDYVHLMNK AAGLAGHDDM
810 820 830 840 850
GALWRQSFEQ ENFVEKMKDL WGELKPFYGE LHKYVRRELM KIYGDKMDAK
860 870 880 890 900
NPNIPAHLLG NMWAQSWVNL YDRIKPFKNA VDLDITKALI DKKYTVKQLF
910 920 930 940 950
DISNDFYVGL GLPDNSMSYD ESRGAVIEKP TDRVVTCHAS AWDLCDRQDF
960 970 980 990 1000
RIKMCTRMNM EDFVTIHHEM GHINYYILYK DQPVTLRAGA NPGFHEAVGD
1010 1020 1030 1040 1050
TIALSVATPK HFKKIGLLDD YEDTHENDIN ALFQKALDRV AFLPFGLLID
1060 1070 1080 1090 1100
MWRWEIFANK VEFADWNKRW WELREEYQMV SAPVDRDVDA FDAGAKYHIP
1110 1120 1130 1140 1150
YDSQYISYFI AHILDLQLHK ALCKEADEYD PEDPAKPLHK CDIDGSTRAG
1160 1170 1180 1190 1200
DLLRAGLSLG RSVHWSEALK AMTGETELKT DALLEYYAPL HEFLKRENEK
1210 1220
ADKDAGVSLV LSSSLVIAVT AVNFLLRLL
Length:1,229
Mass (Da):142,921
Last modified:April 8, 2008 - v1
Checksum:i4ED0D450114DD431
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231872 Genomic DNA. Translation: EDS41405.1.
RefSeqiXP_001845716.1. XM_001845664.1.

Genome annotation databases

EnsemblMetazoaiCPIJ004086-RA; CPIJ004086-PA; CPIJ004086.
GeneIDi6035560.
KEGGicqu:CpipJ_CPIJ004086.
VectorBaseiCPIJ004086-RA; CPIJ004086-PA; CPIJ004086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231872 Genomic DNA. Translation: EDS41405.1.
RefSeqiXP_001845716.1. XM_001845664.1.

3D structure databases

ProteinModelPortaliB0WAI2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7176.CPIJ004086-PA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCPIJ004086-RA; CPIJ004086-PA; CPIJ004086.
GeneIDi6035560.
KEGGicqu:CpipJ_CPIJ004086.
VectorBaseiCPIJ004086-RA; CPIJ004086-PA; CPIJ004086.

Phylogenomic databases

eggNOGiKOG3690. Eukaryota.
ENOG410XPJ3. LUCA.
HOGENOMiHOG000007838.
InParanoidiB0WAI2.
KOiK01283.
OMAiVTMEQLF.
OrthoDBiEOG091G033S.
PhylomeDBiB0WAI2.

Family and domain databases

CDDicd06461. M2_ACE. 2 hits.
InterProiIPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF01401. Peptidase_M2. 2 hits.
[Graphical view]
PRINTSiPR00791. PEPDIPTASEA.
ProtoNetiSearch...

Entry informationi

Entry nameiB0WAI2_CULQU
AccessioniPrimary (citable) accession number: B0WAI2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 30, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.