ID   B0W3G9_CULQU            Unreviewed;       629 AA.
AC   B0W3G9;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   24-JAN-2024, entry version 83.
DE   RecName: Full=DNA polymerase alpha subunit B {ECO:0000256|ARBA:ARBA00018596, ECO:0000256|PIRNR:PIRNR018300};
GN   Name=6032693 {ECO:0000313|EnsemblMetazoa:CPIJ001713-PA};
GN   ORFNames=CpipJ_CPIJ001713 {ECO:0000313|EMBL:EDS31312.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1] {ECO:0000313|EMBL:EDS31312.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS31312.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:CPIJ001713-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ001713-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- FUNCTION: Accessory subunit of the DNA polymerase alpha complex (also
CC       known as the alpha DNA polymerase-primase complex) which plays an
CC       essential role in the initiation of DNA synthesis.
CC       {ECO:0000256|PIRNR:PIRNR018300}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR018300}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase alpha subunit B family.
CC       {ECO:0000256|ARBA:ARBA00007299, ECO:0000256|PIRNR:PIRNR018300}.
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DR   EMBL; DS231831; EDS31312.1; -; Genomic_DNA.
DR   RefSeq; XP_001843253.1; XM_001843201.1.
DR   AlphaFoldDB; B0W3G9; -.
DR   STRING; 7176.B0W3G9; -.
DR   EnsemblMetazoa; CPIJ001713-RA; CPIJ001713-PA; CPIJ001713.
DR   KEGG; cqu:CpipJ_CPIJ001713; -.
DR   VEuPathDB; VectorBase:CPIJ001713; -.
DR   VEuPathDB; VectorBase:CQUJHB012886; -.
DR   eggNOG; KOG1625; Eukaryota.
DR   HOGENOM; CLU_014923_3_0_1; -.
DR   InParanoid; B0W3G9; -.
DR   OMA; QQFDEMG; -.
DR   OrthoDB; 49016at2759; -.
DR   Proteomes; UP000002320; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.21.60; -; 2.
DR   Gene3D; 1.10.8.530; DNA polymerase alpha-primase, subunit B, N-terminal domain; 1.
DR   InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR   InterPro; IPR043034; DNA_pol_alpha_B_N_sf.
DR   InterPro; IPR016722; DNA_pol_alpha_bsu.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   PANTHER; PTHR23061; DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT; 1.
DR   PANTHER; PTHR23061:SF12; DNA POLYMERASE ALPHA SUBUNIT B; 1.
DR   Pfam; PF04042; DNA_pol_E_B; 1.
DR   PIRSF; PIRSF018300; DNA_pol_alph_2; 2.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW   ECO:0000256|PIRNR:PIRNR018300}; Nucleus {ECO:0000256|PIRNR:PIRNR018300};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT   DOMAIN          381..579
FT                   /note="DNA polymerase alpha/delta/epsilon subunit B"
FT                   /evidence="ECO:0000259|Pfam:PF04042"
FT   REGION          145..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          250..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        250..265
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   629 AA;  69324 MW;  99E391C77720DB9A CRC64;
     MVTIQSIKEQ FDEFGLEPSD EIVEKCIQIC NRHGVVDPVE FVEQWFAYSC SKLGGAEPTL
     DNLRDMESHE YANRSRKPAA NPSLARVRHG EVAVVASSSG SGGGSGGLVI YSNAEENEVE
     NEVLGSYGCH TPKTKKRPVS RLLAQTPDKP NKAQFAPASY SPIAPSKKSA DEEQPSNSGN
     VVYTFGNAFL LKQTSWSSSA TAGAPSDDLP KCMGDACKYM YDSNYDRVLI LGDRIYEGGR
     EICQRLAEAR KQQRDRGNGA SAEEEVIPED DREATLLEQV AIHHVDYPST DVITVLGRIA
     VHPERQEGGR LAIVDYDEMT LRYTKLDFSK LKSWSVFPGE TVVLEGVNPR GNLFEVRKVH
     YEVPLAPPPA PTTIGKPLHM VIGAAPFTDK DNLQYDKLSD LLAYCAENNP DVLILTGPFG
     STSNDTLFLT IAESFEEYFE KIMANIVTSV PPTTEILIVS NHDDLQSSFV YPSFPYKISK
     FYKNLHFLPD PCVVSINGMH VAITTVDVVR DLSEAELSVA PSGDKIKRAF NYMFHHRSFY
     PLNPPPESVP LDVDLLHHFG TLPRVPNVMI CPGDLKPYVR DVNGCVCVNP GHLTDYDSGE
     GTFARVVVHP PEEPTAAPFS YVACQVVKS
//