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B0W2R4 (CALYP_CULQU) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase calypso

EC=3.4.19.12
Alternative name(s):
BAP1 homolog
Gene names
Name:calypso
ORF Names:CPIJ001439
OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens) [Complete proteome]
Taxonomic identifier7176 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Component of the PR-DUB complex By similarity.

Subcellular location

Nucleus By similarity. Note: Localizes to PcG response elements (PREs) By similarity.

Sequence similarities

Belongs to the peptidase C12 family. BAP1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470Ubiquitin carboxyl-terminal hydrolase calypso
PRO_0000395825

Sites

Active site981Nucleophile By similarity
Active site1771Proton donor By similarity
Site1921Important for enzyme activity By similarity

Sequences

Sequence LengthMass (Da)Tools
B0W2R4 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: D894D640FC6CCBE8

FASTA47053,180
        10         20         30         40         50         60 
MPVDINRLTD GWLELESDPG LFTLLLEDFG VKGVQVEEIY DLQKTIEGPV FGFIFLFRWI 

        70         80         90        100        110        120 
EERRARRKIV ETTTEMYVKD EEAVNSIFFA HQVVPNSCAT HALLSVLLNC SDIDLGTTLS 

       130        140        150        160        170        180 
RLKVHTKGMC PDNKGWAIGN TPELACAHNS HAMPQARRRM DRNSGVSTGR FTGEAFHFVS 

       190        200        210        220        230        240 
FCPINGHLFE LDGLKPFPMD HGPWGEKEDW TDKFRRVMSD RLGISTDRRI AITHKLKMLR 

       250        260        270        280        290        300 
TNQTIVSAAL EKLLKSKQLE SRSQAEIRET VDKIKKEEQE STVKLSSEYS QLLEMHEKDE 

       310        320        330        340        350        360 
PAVAMSKELE SLVSLNSSSD SVEIIGETEI KKENPPPSPP PAFIGAGTFS PKDLLSLLKN 

       370        380        390        400        410        420 
LESEINITEQ HLCDENEKRA MFKVDDCRRT HNYDEFICTF LSMLAYQGEL GDLVTQHLVT 

       430        440        450        460        470 
SRKPSLGGVQ NSGSRGVVRN YNKKSTTNGS SPKTPSSKRR RGRTKYRKRK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS231828 Genomic DNA. Translation: EDS29817.1.
RefSeqXP_001842998.1. XM_001842946.1.
UniGeneCpi.8966.

3D structure databases

ProteinModelPortalB0W2R4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7176.CPIJ001439-PA.

Protein family/group databases

MEROPSC12.A09.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCPIJ001439-RA; CPIJ001439-PA; CPIJ001439.
GeneID6032393.
KEGGcqu:CpipJ_CPIJ001439.
VectorBaseCPIJ001439. Culex quinquefasciatus.

Phylogenomic databases

eggNOGNOG249036.
HOGENOMHOG000203918.
KOK08588.
OMATDKFRRV.
OrthoDBEOG7GN2M2.
PhylomeDBB0W2R4.

Family and domain databases

Gene3D3.40.532.10. 1 hit.
InterProIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERPTHR10589. PTHR10589. 1 hit.
PfamPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSPR00707. UBCTHYDRLASE.
ProtoNetSearch...

Entry information

Entry nameCALYP_CULQU
AccessionPrimary (citable) accession number: B0W2R4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: April 8, 2008
Last modified: March 19, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries