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B0W2R4

- CALYP_CULQU

UniProt

B0W2R4 - CALYP_CULQU

Protein

Ubiquitin carboxyl-terminal hydrolase calypso

Gene

calypso

Organism
Culex quinquefasciatus (Southern house mosquito) (Culex pungens)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1) By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei98 – 981NucleophileBy similarity
    Active sitei177 – 1771Proton donorBy similarity
    Sitei192 – 1921Important for enzyme activityBy similarity

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. ubiquitin-specific protease activity Source: UniProtKB
    3. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. chromatin silencing Source: UniProtKB
    2. monoubiquitinated histone H2A deubiquitination Source: UniProtKB
    3. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC12.A09.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase calypso (EC:3.4.19.12)
    Alternative name(s):
    BAP1 homolog
    Gene namesi
    Name:calypso
    ORF Names:CPIJ001439
    OrganismiCulex quinquefasciatus (Southern house mosquito) (Culex pungens)
    Taxonomic identifieri7176 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex
    ProteomesiUP000002320: Partially assembled WGS sequence

    Subcellular locationi

    Nucleus By similarity
    Note: Localizes to PcG response elements (PREs).By similarity

    GO - Cellular componenti

    1. nuclear chromatin Source: UniProtKB
    2. PR-DUB complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 470470Ubiquitin carboxyl-terminal hydrolase calypsoPRO_0000395825Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the PR-DUB complex.By similarity

    Protein-protein interaction databases

    STRINGi7176.CPIJ001439-PA.

    Structurei

    3D structure databases

    ProteinModelPortaliB0W2R4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C12 family. BAP1 subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG249036.
    HOGENOMiHOG000203918.
    KOiK08588.
    OMAiTDKFRRV.
    OrthoDBiEOG7GN2M2.
    PhylomeDBiB0W2R4.

    Family and domain databases

    Gene3Di3.40.532.10. 1 hit.
    InterProiIPR001578. Peptidase_C12_UCH.
    [Graphical view]
    PANTHERiPTHR10589. PTHR10589. 1 hit.
    PfamiPF01088. Peptidase_C12. 1 hit.
    [Graphical view]
    PRINTSiPR00707. UBCTHYDRLASE.

    Sequencei

    Sequence statusi: Complete.

    B0W2R4-1 [UniParc]FASTAAdd to Basket

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    MPVDINRLTD GWLELESDPG LFTLLLEDFG VKGVQVEEIY DLQKTIEGPV    50
    FGFIFLFRWI EERRARRKIV ETTTEMYVKD EEAVNSIFFA HQVVPNSCAT 100
    HALLSVLLNC SDIDLGTTLS RLKVHTKGMC PDNKGWAIGN TPELACAHNS 150
    HAMPQARRRM DRNSGVSTGR FTGEAFHFVS FCPINGHLFE LDGLKPFPMD 200
    HGPWGEKEDW TDKFRRVMSD RLGISTDRRI AITHKLKMLR TNQTIVSAAL 250
    EKLLKSKQLE SRSQAEIRET VDKIKKEEQE STVKLSSEYS QLLEMHEKDE 300
    PAVAMSKELE SLVSLNSSSD SVEIIGETEI KKENPPPSPP PAFIGAGTFS 350
    PKDLLSLLKN LESEINITEQ HLCDENEKRA MFKVDDCRRT HNYDEFICTF 400
    LSMLAYQGEL GDLVTQHLVT SRKPSLGGVQ NSGSRGVVRN YNKKSTTNGS 450
    SPKTPSSKRR RGRTKYRKRK 470
    Length:470
    Mass (Da):53,180
    Last modified:April 8, 2008 - v1
    Checksum:iD894D640FC6CCBE8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS231828 Genomic DNA. Translation: EDS29817.1.
    RefSeqiXP_001842998.1. XM_001842946.1.
    UniGeneiCpi.8966.

    Genome annotation databases

    EnsemblMetazoaiCPIJ001439-RA; CPIJ001439-PA; CPIJ001439.
    GeneIDi6032393.
    KEGGicqu:CpipJ_CPIJ001439.
    VectorBaseiCPIJ001439. Culex quinquefasciatus.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS231828 Genomic DNA. Translation: EDS29817.1 .
    RefSeqi XP_001842998.1. XM_001842946.1.
    UniGenei Cpi.8966.

    3D structure databases

    ProteinModelPortali B0W2R4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7176.CPIJ001439-PA.

    Protein family/group databases

    MEROPSi C12.A09.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CPIJ001439-RA ; CPIJ001439-PA ; CPIJ001439 .
    GeneIDi 6032393.
    KEGGi cqu:CpipJ_CPIJ001439.
    VectorBasei CPIJ001439. Culex quinquefasciatus.

    Phylogenomic databases

    eggNOGi NOG249036.
    HOGENOMi HOG000203918.
    KOi K08588.
    OMAi TDKFRRV.
    OrthoDBi EOG7GN2M2.
    PhylomeDBi B0W2R4.

    Family and domain databases

    Gene3Di 3.40.532.10. 1 hit.
    InterProi IPR001578. Peptidase_C12_UCH.
    [Graphical view ]
    PANTHERi PTHR10589. PTHR10589. 1 hit.
    Pfami PF01088. Peptidase_C12. 1 hit.
    [Graphical view ]
    PRINTSi PR00707. UBCTHYDRLASE.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JHB.

    Entry informationi

    Entry nameiCALYP_CULQU
    AccessioniPrimary (citable) accession number: B0W2R4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3