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B0W2R4

- CALYP_CULQU

UniProt

B0W2R4 - CALYP_CULQU

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Protein

Ubiquitin carboxyl-terminal hydrolase calypso

Gene
calypso, CPIJ001439
Organism
Culex quinquefasciatus (Southern house mosquito) (Culex pungens)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1) By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei98 – 981Nucleophile By similarity
Active sitei177 – 1771Proton donor By similarity
Sitei192 – 1921Important for enzyme activity By similarity

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. ubiquitin-specific protease activity Source: UniProtKB
  3. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. chromatin silencing Source: UniProtKB
  2. monoubiquitinated histone H2A deubiquitination Source: UniProtKB
  3. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC12.A09.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase calypso (EC:3.4.19.12)
Alternative name(s):
BAP1 homolog
Gene namesi
Name:calypso
ORF Names:CPIJ001439
OrganismiCulex quinquefasciatus (Southern house mosquito) (Culex pungens)
Taxonomic identifieri7176 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex
ProteomesiUP000002320: Partially assembled WGS sequence

Subcellular locationi

Nucleus By similarity
Note: Localizes to PcG response elements (PREs) By similarity.

GO - Cellular componenti

  1. nuclear chromatin Source: UniProtKB
  2. PR-DUB complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Ubiquitin carboxyl-terminal hydrolase calypsoPRO_0000395825Add
BLAST

Interactioni

Subunit structurei

Component of the PR-DUB complex By similarity.

Protein-protein interaction databases

STRINGi7176.CPIJ001439-PA.

Structurei

3D structure databases

ProteinModelPortaliB0W2R4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG249036.
HOGENOMiHOG000203918.
KOiK08588.
OMAiTDKFRRV.
OrthoDBiEOG7GN2M2.
PhylomeDBiB0W2R4.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.

Sequencei

Sequence statusi: Complete.

B0W2R4-1 [UniParc]FASTAAdd to Basket

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MPVDINRLTD GWLELESDPG LFTLLLEDFG VKGVQVEEIY DLQKTIEGPV    50
FGFIFLFRWI EERRARRKIV ETTTEMYVKD EEAVNSIFFA HQVVPNSCAT 100
HALLSVLLNC SDIDLGTTLS RLKVHTKGMC PDNKGWAIGN TPELACAHNS 150
HAMPQARRRM DRNSGVSTGR FTGEAFHFVS FCPINGHLFE LDGLKPFPMD 200
HGPWGEKEDW TDKFRRVMSD RLGISTDRRI AITHKLKMLR TNQTIVSAAL 250
EKLLKSKQLE SRSQAEIRET VDKIKKEEQE STVKLSSEYS QLLEMHEKDE 300
PAVAMSKELE SLVSLNSSSD SVEIIGETEI KKENPPPSPP PAFIGAGTFS 350
PKDLLSLLKN LESEINITEQ HLCDENEKRA MFKVDDCRRT HNYDEFICTF 400
LSMLAYQGEL GDLVTQHLVT SRKPSLGGVQ NSGSRGVVRN YNKKSTTNGS 450
SPKTPSSKRR RGRTKYRKRK 470
Length:470
Mass (Da):53,180
Last modified:April 8, 2008 - v1
Checksum:iD894D640FC6CCBE8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS231828 Genomic DNA. Translation: EDS29817.1.
RefSeqiXP_001842998.1. XM_001842946.1.
UniGeneiCpi.8966.

Genome annotation databases

EnsemblMetazoaiCPIJ001439-RA; CPIJ001439-PA; CPIJ001439.
GeneIDi6032393.
KEGGicqu:CpipJ_CPIJ001439.
VectorBaseiCPIJ001439. Culex quinquefasciatus.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS231828 Genomic DNA. Translation: EDS29817.1 .
RefSeqi XP_001842998.1. XM_001842946.1.
UniGenei Cpi.8966.

3D structure databases

ProteinModelPortali B0W2R4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7176.CPIJ001439-PA.

Protein family/group databases

MEROPSi C12.A09.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CPIJ001439-RA ; CPIJ001439-PA ; CPIJ001439 .
GeneIDi 6032393.
KEGGi cqu:CpipJ_CPIJ001439.
VectorBasei CPIJ001439. Culex quinquefasciatus.

Phylogenomic databases

eggNOGi NOG249036.
HOGENOMi HOG000203918.
KOi K08588.
OMAi TDKFRRV.
OrthoDBi EOG7GN2M2.
PhylomeDBi B0W2R4.

Family and domain databases

Gene3Di 3.40.532.10. 1 hit.
InterProi IPR001578. Peptidase_C12_UCH.
[Graphical view ]
PANTHERi PTHR10589. PTHR10589. 1 hit.
Pfami PF01088. Peptidase_C12. 1 hit.
[Graphical view ]
PRINTSi PR00707. UBCTHYDRLASE.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JHB.

Entry informationi

Entry nameiCALYP_CULQU
AccessioniPrimary (citable) accession number: B0W2R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: April 8, 2008
Last modified: March 19, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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