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Protein

Ubiquitin carboxyl-terminal hydrolase calypso

Gene

calypso

Organism
Culex quinquefasciatus (Southern house mosquito) (Culex pungens)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1) (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei98 – 981NucleophileBy similarity
Active sitei177 – 1771Proton donorBy similarity
Sitei192 – 1921Important for enzyme activityBy similarity

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. chromatin silencing Source: UniProtKB
  2. monoubiquitinated histone H2A deubiquitination Source: UniProtKB
  3. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC12.A09.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase calypso (EC:3.4.19.12)
Alternative name(s):
BAP1 homolog
Gene namesi
Name:calypso
ORF Names:CPIJ001439
OrganismiCulex quinquefasciatus (Southern house mosquito) (Culex pungens)
Taxonomic identifieri7176 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex
ProteomesiUP000002320 Componenti: Partially assembled WGS sequence

Subcellular locationi

Nucleus By similarity
Note: Localizes to PcG response elements (PREs).By similarity

GO - Cellular componenti

  1. nuclear chromatin Source: UniProtKB
  2. PR-DUB complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Ubiquitin carboxyl-terminal hydrolase calypsoPRO_0000395825Add
BLAST

Interactioni

Subunit structurei

Component of the PR-DUB complex.By similarity

Protein-protein interaction databases

STRINGi7176.CPIJ001439-PA.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C12 family. BAP1 subfamily.Curated

Phylogenomic databases

eggNOGiNOG249036.
HOGENOMiHOG000203918.
InParanoidiB0W2R4.
KOiK08588.
OMAiAFHFVSF.
OrthoDBiEOG7GN2M2.
PhylomeDBiB0W2R4.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.

Sequencei

Sequence statusi: Complete.

B0W2R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVDINRLTD GWLELESDPG LFTLLLEDFG VKGVQVEEIY DLQKTIEGPV
60 70 80 90 100
FGFIFLFRWI EERRARRKIV ETTTEMYVKD EEAVNSIFFA HQVVPNSCAT
110 120 130 140 150
HALLSVLLNC SDIDLGTTLS RLKVHTKGMC PDNKGWAIGN TPELACAHNS
160 170 180 190 200
HAMPQARRRM DRNSGVSTGR FTGEAFHFVS FCPINGHLFE LDGLKPFPMD
210 220 230 240 250
HGPWGEKEDW TDKFRRVMSD RLGISTDRRI AITHKLKMLR TNQTIVSAAL
260 270 280 290 300
EKLLKSKQLE SRSQAEIRET VDKIKKEEQE STVKLSSEYS QLLEMHEKDE
310 320 330 340 350
PAVAMSKELE SLVSLNSSSD SVEIIGETEI KKENPPPSPP PAFIGAGTFS
360 370 380 390 400
PKDLLSLLKN LESEINITEQ HLCDENEKRA MFKVDDCRRT HNYDEFICTF
410 420 430 440 450
LSMLAYQGEL GDLVTQHLVT SRKPSLGGVQ NSGSRGVVRN YNKKSTTNGS
460 470
SPKTPSSKRR RGRTKYRKRK
Length:470
Mass (Da):53,180
Last modified:April 8, 2008 - v1
Checksum:iD894D640FC6CCBE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231828 Genomic DNA. Translation: EDS29817.1.
RefSeqiXP_001842998.1. XM_001842946.1.
UniGeneiCpi.8966.

Genome annotation databases

EnsemblMetazoaiCPIJ001439-RA; CPIJ001439-PA; CPIJ001439.
GeneIDi6032393.
KEGGicqu:CpipJ_CPIJ001439.
VectorBaseiCPIJ001439. Culex quinquefasciatus.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231828 Genomic DNA. Translation: EDS29817.1.
RefSeqiXP_001842998.1. XM_001842946.1.
UniGeneiCpi.8966.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7176.CPIJ001439-PA.

Protein family/group databases

MEROPSiC12.A09.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCPIJ001439-RA; CPIJ001439-PA; CPIJ001439.
GeneIDi6032393.
KEGGicqu:CpipJ_CPIJ001439.
VectorBaseiCPIJ001439. Culex quinquefasciatus.

Phylogenomic databases

eggNOGiNOG249036.
HOGENOMiHOG000203918.
InParanoidiB0W2R4.
KOiK08588.
OMAiAFHFVSF.
OrthoDBiEOG7GN2M2.
PhylomeDBiB0W2R4.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JHB.

Entry informationi

Entry nameiCALYP_CULQU
AccessioniPrimary (citable) accession number: B0W2R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: April 8, 2008
Last modified: April 1, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.