ID B0W2B8_CULQU Unreviewed; 741 AA. AC B0W2B8; DT 08-APR-2008, integrated into UniProtKB/TrEMBL. DT 08-APR-2008, sequence version 1. DT 27-MAR-2024, entry version 93. DE SubName: Full=Axis inhibition protein {ECO:0000313|EMBL:EDS28733.1, ECO:0000313|EnsemblMetazoa:CPIJ001221-PA}; GN Name=6032253 {ECO:0000313|EnsemblMetazoa:CPIJ001221-PA}; GN ORFNames=CpipJ_CPIJ001221 {ECO:0000313|EMBL:EDS28733.1}; OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; OC Culicinae; Culicini; Culex; Culex. OX NCBI_TaxID=7176; RN [1] {ECO:0000313|EMBL:EDS28733.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JHB {ECO:0000313|EMBL:EDS28733.1}; RG The Broad Institute Genome Sequencing Platform; RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C., RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E., RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P., RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F., RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D., RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J., RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E., RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.; RT "Annotation of Culex pipiens quinquefasciatus."; RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ001221-PA} RP IDENTIFICATION. RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ001221-PA}; RG EnsemblMetazoa; RL Submitted (MAY-2020) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DS231826; EDS28733.1; -; Genomic_DNA. DR RefSeq; XP_001842890.1; XM_001842838.1. DR AlphaFoldDB; B0W2B8; -. DR STRING; 7176.B0W2B8; -. DR EnsemblMetazoa; CPIJ001221-RA; CPIJ001221-PA; CPIJ001221. DR KEGG; cqu:CpipJ_CPIJ001221; -. DR VEuPathDB; VectorBase:CPIJ001221; -. DR VEuPathDB; VectorBase:CQUJHB012577; -. DR eggNOG; KOG3589; Eukaryota. DR HOGENOM; CLU_016422_0_0_1; -. DR InParanoid; B0W2B8; -. DR OMA; YVYTAST; -. DR OrthoDB; 4256282at2759; -. DR Proteomes; UP000002320; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:InterPro. DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW. DR Gene3D; 1.10.196.10; -; 1. DR Gene3D; 2.40.240.130; -; 1. DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1. DR InterPro; IPR043581; Axin-like. DR InterPro; IPR014936; Axin_b-cat-bd. DR InterPro; IPR001158; DIX. DR InterPro; IPR038207; DIX_dom_sf. DR InterPro; IPR016137; RGS. DR InterPro; IPR036305; RGS_sf. DR InterPro; IPR024066; RGS_subdom1/3. DR InterPro; IPR044926; RGS_subdomain_2. DR InterPro; IPR029071; Ubiquitin-like_domsf. DR PANTHER; PTHR46102; AXIN; 1. DR PANTHER; PTHR46102:SF2; AXIN; 1. DR Pfam; PF08833; Axin_b-cat_bind; 1. DR Pfam; PF00778; DIX; 1. DR Pfam; PF00615; RGS; 1. DR SMART; SM00021; DAX; 1. DR SMART; SM00315; RGS; 1. DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1. DR SUPFAM; SSF54236; Ubiquitin-like; 1. DR PROSITE; PS50841; DIX; 1. DR PROSITE; PS50132; RGS; 1. PE 4: Predicted; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Reference proteome {ECO:0000313|Proteomes:UP000002320}; KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|PROSITE- KW ProRule:PRU00069}. FT DOMAIN 52..176 FT /note="RGS" FT /evidence="ECO:0000259|PROSITE:PS50132" FT DOMAIN 657..740 FT /note="DIX" FT /evidence="ECO:0000259|PROSITE:PS50841" FT REGION 1..41 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 275..294 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 328..368 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 479..500 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 599..625 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 22..36 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 275..292 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 328..359 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 479..493 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 602..616 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 741 AA; 82362 MW; 07C5713361BF8839 CRC64; MSQYSFSKFD DFTCSGPRPP VPGEESRRKM TDTLHPDKSR TSPPAYCRWA NNVSYLLDDS DGAELFKRFV ELEDEEHLNH LNFYFACQGL KRERNPERML MMIGVIYRKF LKRAPRGSPM YVDEEMRVMI KAGLRNDGHV ILTPDVFDQM QENVVSIISS TTYPNFLQSD LYLQYVQNMQ TSSGSGSGGG SCISIPLGVA AAAAASSSSA GGAVSSMTSS SSTSELISYS SSALPTLHED SELLVNADSI EQLYGATGPA IAASSLSVTS GVSGSGSASS CTSMSTSKPA MTLTKDALRA TEKRRLEMRP SGPRAGFSVY TKYSSYNPVS RRDSEQASLS SGRTDSDTMS LSSISTDGRP HPHNMHRNHH QASLERRLIH ENAMVNSELN RHAIIPRTQR MNQKPLPKEE FVSQLMSKLE KVKKLQDNDE LLGKKLQEAD QSTNSQSNKF FAEQIRQKLQ VEDETDQDIL DQHVSRVFSD LTPNRSPGRV SPSPNINRAR RHEMGSFGSM SAQSSMRHSK SMPEGHQLGL MGPPAQPHPR KLSNKWPSVN TDSGISLFSS DTLTKYSNKD MQCASTSTSR PLSRTMHCDM SVMNTATLLQ ESSRRLEDET RRSKRYQHSG QPMIQTMPLP PLPPSAMTHP SSLLPPPIPA KPSQGLPGFT VVVYSFCDEE VPYRIKIPGS NPPTLRQFKE YLPKKGNYRF FFKTRCDDVD NPVYQEEINN DNEMLPLFEG KVMGTVKPIE V //