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Protein

Superoxide dismutase [Cu-Zn]

Gene

CpipJ_CPIJ000146

Organism
Culex quinquefasciatus (Southern house mosquito) (Culex pungens)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
ORF Names:CpipJ_CPIJ000146Imported
OrganismiCulex quinquefasciatus (Southern house mosquito) (Culex pungens)Imported
Taxonomic identifieri7176 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex
ProteomesiUP000002320: Partially assembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi7176.CPIJ000146-PA.

Structurei

3D structure databases

ProteinModelPortaliB0VZ56.
SMRiB0VZ56. Positions 22-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263447.
InParanoidiB0VZ56.
KOiK04565.
OMAiCATICSA.
OrthoDBiEOG776SR4.
PhylomeDBiB0VZ56.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0VZ56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLIVLAIF GCSTLLVNAD QAKKAIVFLQ STAGVVGNVT LSQPSCTEPV
60 70 80 90 100
FIEVSVIGLT PGKHGFHIHE KGDLSDGCAS TGGHYNPDKV SHGAPNDQVR
110 120 130 140 150
HVGDLGNILA DEHGIAKTSF SDTVVSLYGS RSVLGRGIVI HAEIDDLGKT
160 170
NHPDSLKTGN AGGRVACGVI GVL
Length:173
Mass (Da):17,875
Last modified:April 8, 2008 - v1
Checksum:i7903159B07411396
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231813 Genomic DNA. Translation: EDS25769.1.
RefSeqiXP_001841816.1. XM_001841764.1.
UniGeneiCpi.1106.

Genome annotation databases

EnsemblMetazoaiCPIJ000146-RA; CPIJ000146-PA; CPIJ000146.
GeneIDi6030958.
KEGGicqu:CpipJ_CPIJ000146.
VectorBaseiCPIJ000146. Culex quinquefasciatus.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231813 Genomic DNA. Translation: EDS25769.1.
RefSeqiXP_001841816.1. XM_001841764.1.
UniGeneiCpi.1106.

3D structure databases

ProteinModelPortaliB0VZ56.
SMRiB0VZ56. Positions 22-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7176.CPIJ000146-PA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCPIJ000146-RA; CPIJ000146-PA; CPIJ000146.
GeneIDi6030958.
KEGGicqu:CpipJ_CPIJ000146.
VectorBaseiCPIJ000146. Culex quinquefasciatus.

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263447.
InParanoidiB0VZ56.
KOiK04565.
OMAiCATICSA.
OrthoDBiEOG776SR4.
PhylomeDBiB0VZ56.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JHBImported.

Entry informationi

Entry nameiB0VZ56_CULQU
AccessioniPrimary (citable) accession number: B0VZ56
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: January 7, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.