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B0VXL7 (CDK14_CALMO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 14

EC=2.7.11.22
Alternative name(s):
Cell division protein kinase 14
Gene names
Name:CDK14
Synonyms:PFTK1
OrganismCallicebus moloch (Dusky titi monkey)
Taxonomic identifier9523 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniPitheciidaeCallicebinaeCallicebus

Protein attributes

Sequence length451 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Serine/threonine-protein kinase activity is promoted by associated cyclins CCDN3 and CCNY and repressed by CDKN1A By similarity.

Subunit structure

Interacts with CCNY; CCNY mediates its recruitment to the plasma membrane and promotes phosphorylation of LRP6. Interacts with CCDN3 and CDKN1A. Interacts with SEPT8. Interacts with 14-3-3 proteina YWHAB, YWHAE, YWHAH and YWHAQ By similarity.

Subcellular location

Cell membrane; Peripheral membrane protein By similarity. Cytoplasm By similarity. Nucleus By similarity. Note: Recruited to the cell membrane by CCNY By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 451451Cyclin-dependent kinase 14
PRO_0000391898

Regions

Domain117 – 401285Protein kinase
Nucleotide binding123 – 1319ATP By similarity

Sites

Active site2381Proton acceptor By similarity
Binding site1461ATP By similarity

Amino acid modifications

Modified residue771Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
B0VXL7 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: B436467A7E830EA9

FASTA45150,690
        10         20         30         40         50         60 
MHGYFGCNAA AEPGYSAFLG TPQICVTKMS TRNCQGMDSV IKPLDTIPED KKVRVQRTQS 

        70         80         90        100        110        120 
TFDPFEKPAN QVKRVHSENN ACINFKTSST GKESPKVRRH SSPSSPTSPK FGKADSYEKL 

       130        140        150        160        170        180 
EKLGEGSYAT VYKGKSKVNG KLVALKVIRL QEEEGTPFTA IREASLLKGL KHANIVLLHD 

       190        200        210        220        230        240 
IIHTKETLTL VFEYVHTDLC QYMDKHPGGL HPDNVKLFLF QLLRGLSYIH QRYILHRDLK 

       250        260        270        280        290        300 
PQNLLISDTG ELKLADFGLA RAKSVPSHTY SNEVVTLWYR PPDVLLGSTE YSTCLDMWGV 

       310        320        330        340        350        360 
GCIFVEMIQG VAAFPGMKDI QDQLERIFLV LGTPNEDTWP GVHSLPHFKP ERFTLYSSKN 

       370        380        390        400        410        420 
LRQAWNKLSY VNHAEDLASK LLQCSPKNRL SAQAALSHEY FSDLPPRLWE LTDMSSIFTI 

       430        440        450 
PNVRLQPEAG ESMRAFGKNN SYGKSLSNSK H 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DP000601 Genomic DNA. Translation: ACA35057.1.

3D structure databases

ProteinModelPortalB0VXL7.
SMRB0VXL7. Positions 117-404.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG014652.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDK14_CALMO
AccessionPrimary (citable) accession number: B0VXL7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: April 8, 2008
Last modified: February 19, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families