Reviewed, UniProtKB/Swiss-Prot B0VXK3 (HXA2_CALJA)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A2

Gene names

Name:

HOXA2

Organism

Callithrix jacchus (Common marmoset)

Taxonomic identifier

9483 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Cebidae › Callitrichinae › Callithrix

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Proboscipedia subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 375	375	Homeobox protein Hox-A2		PRO_0000333801
Regions
	DNA binding	142 – 201	60	Homeobox
	Motif	94 – 99	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	B0VXK3-1 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: D3601640086FDACC	FASTA	375	40,949
	10 20 30 40 50 60 MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS SLSHSTLIPP PFEQTIPSLN 70 80 90 100 110 120 PGSHPRHGAG GRPKPSPAGS RGSPVPAGAL QPPEYPWMKE KKAAKKTALP PASAAAAAAA 130 140 150 160 170 180 TGPACLSHKE SLEIADGSGG GSRRLRTAYT NTQLLELEKE FHFNKYLCRP RRVEIAALLD 190 200 210 220 230 240 LTERQVKVWF QNRRMKHKRQ TQCKENQNSE GKCKSLEDSE KVEDDDEEKT LFEQALSVSG 250 260 270 280 290 300 ALLEREGYTF QQNTLSQQQA PNGHNGDSQS FPVSPLTSNE KNLKHFQHQS PTVPNCLSTM 310 320 330 340 350 360 GQNCGAGLNN DSPEALEVPS LQDFNVFSTD SCLQLSDAVS PSLPGSLDSP VDISADSFDF 370 FTDTLTTIDL QHLNY

References

[1]

"NISC comparative sequencing initiative." Antonellis A., Benjamin B., Blakesley R.W., Bouffard G.G., Brinkley C., Brooks S., Chu G., Chub I., Coleman H., Fuksenko T., Gestole M., Gregory M., Guan X., Gupta J., Gurson N., Han E., Han J., Hansen N. , Hargrove A., Hines-Harris K., Ho S.-L., Hu P., Hunter G., Hurle B., Idol J.R., Johnson T., Knight E., Kwong P., Lee-Lin S.-Q., Legaspi R., Madden M., Maduro Q.L., Maduro V.B., Margulies E.H., Masiello C., Maskeri B., McDowell J., Merkulov G., Montemayor C., Mullikin J.C., Park M., Prasad A., Ramsahoye C., Reddix-Dugue N., Riebow N., Schandler K., Schueler M.G., Sison C., Smith L., Stantripop S., Thomas J.W., Thomas P.J., Tsipouri V., Young A., Green E.D. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	DP000594 Genomic DNA. Translation: ABZ80206.1.
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSCJAT00000015668; ENSCJAP00000014851; ENSCJAG00000008032; Callithrix jacchus. [Genome view]
Family and domain databases
InterPro	IPR001356. Homeobox. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA2_CALJA

Accession

Primary (citable) accession number: B0VXK3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	April 8, 2008
Last modified:	November 24, 2009
This is version 9 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)