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B0VXE8

- CDK14_CALJA

UniProt

B0VXE8 - CDK14_CALJA

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Protein
Cyclin-dependent kinase 14
Gene
CDK14, PFTK1
Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Serine/threonine-protein kinase activity is promoted by associated cyclins CCDN3 and CCNY and repressed by CDKN1A By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181ATP By similarity
Active sitei210 – 2101Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi95 – 1039ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. G2/M transition of mitotic cell cycle Source: UniProtKB
  2. Wnt signaling pathway Source: UniProtKB-KW
  3. cell division Source: UniProtKB-KW
  4. regulation of canonical Wnt signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 14 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 14
Gene namesi
Name:CDK14
Synonyms:PFTK1
OrganismiCallithrix jacchus (White-tufted-ear marmoset)
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix
ProteomesiUP000008225: Chromosome 8

Subcellular locationi

Cell membrane; Peripheral membrane protein By similarity. Cytoplasm By similarity. Nucleus By similarity
Note: Recruited to the cell membrane by CCNY By similarity.

GO - Cellular componenti

  1. cytoplasmic cyclin-dependent protein kinase holoenzyme complex Source: UniProtKB
  2. nucleus Source: UniProtKB-SubCell
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Cyclin-dependent kinase 14
PRO_0000391899Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiB0VXE8.

Interactioni

Subunit structurei

Interacts with CCNY; CCNY mediates its recruitment to the plasma membrane and promotes phosphorylation of LRP6. Interacts with CCDN3 and CDKN1A. Interacts with SEPT8. Interacts with 14-3-3 proteina YWHAB, YWHAE, YWHAH and YWHAQ By similarity.

Structurei

3D structure databases

ProteinModelPortaliB0VXE8.
SMRiB0VXE8. Positions 89-376.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini89 – 373285Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00600000083998.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0VXE8-1 [UniParc]FASTAAdd to Basket

« Hide

MSTRNCQGMD SVIKPLDTIP EDKKVRVQRT QSTFDPFEKP TNQVKRVHSE    50
NNACINFKTS STGKESPKVR RHSSPSSPTS PKFGKADSYE KLEKLGEGSY 100
ATVYKGKSKV NGKLVALKVI RLQEEEGTPF TAIREASLLK GLKHANIVLL 150
HDIIHTKETL TLVFEYVHTD LCQYMDKHPG GLHPDNVKLF LFQLLRGLSY 200
IHQRYILHRD LKPQNLLISD TGELKLADFG LARAKSVPSH TYSNEVVTLW 250
YRPPDVLLGS TEYSTCLDMW GVGCIFVEMI QGVAAFPGMK DIQDQLERIF 300
LVLGTPNEDT WPGVHSLPHF KPERFTLYSS KNLRQAWNKL SYVNHAEDLA 350
SKLLQCSPKN RLSAQAALSH EYFSDLPPRL WELTDMSSIF TVPNVRLQPE 400
AGESMRAFGK NNSYGKSLSN SKH 423
Length:423
Mass (Da):47,790
Last modified:April 8, 2008 - v1
Checksum:iA62C5C5DDA12F18A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000590 Genomic DNA. Translation: ABZ80269.1.

Genome annotation databases

EnsembliENSCJAT00000027606; ENSCJAP00000026123; ENSCJAG00000014175.
ENSCJAT00000060883; ENSCJAP00000043575; ENSCJAG00000014175.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000590 Genomic DNA. Translation: ABZ80269.1 .

3D structure databases

ProteinModelPortali B0VXE8.
SMRi B0VXE8. Positions 89-376.
ModBasei Search...

Proteomic databases

PRIDEi B0VXE8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCJAT00000027606 ; ENSCJAP00000026123 ; ENSCJAG00000014175 .
ENSCJAT00000060883 ; ENSCJAP00000043575 ; ENSCJAG00000014175 .

Phylogenomic databases

GeneTreei ENSGT00600000083998.
HOGENOMi HOG000233024.
HOVERGENi HBG014652.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCDK14_CALJA
AccessioniPrimary (citable) accession number: B0VXE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: April 8, 2008
Last modified: February 19, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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