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Protein
Submitted name:

Isocitrate dehydrogenase

Gene

idh

Organism
Acinetobacter baumannii (strain SDF)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysisUniRule annotation
Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
Sitei422 – 4221Critical for catalysisUniRule annotation
Binding sitei550 – 5501SubstrateUniRule annotation
Metal bindingi551 – 5511Magnesium or manganeseUniRule annotation
Metal bindingi555 – 5551Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
Gene namesi
Name:idhImported
Ordered Locus Names:ABSDF0995Imported
OrganismiAcinetobacter baumannii (strain SDF)Imported
Taxonomic identifieri509170 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
ProteomesiUP000001741 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi509170.ABSDF0995.

Structurei

3D structure databases

ProteinModelPortaliB0VTR7.
SMRiB0VTR7. Positions 8-741.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiNSGQMWG.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

B0VTR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEKSTIIY TLTDEAPLLA TYSLLPIIET FTKPAGIEIV KSDISVAARV
60 70 80 90 100
LAEFADYLSE EQKVSDNLAE LGRLTQDPDT NIIKLPNISA SVAQLTACIK
110 120 130 140 150
ELQSKGYAIP DYPENPATEE EKTIKARYGK CLGSAVNPVL REGNSDRRAP
160 170 180 190 200
AAVKNYAKKH PHSMSEWKQW SQTHVSHMEE GDFYHGEKSM TLDRPRNVKM
210 220 230 240 250
ELITNSGKSI VLKPKVALQE GEIIDSMFMS KKALCDFYEK QLDDCREAGI
260 270 280 290 300
LFSLHVKATM MKVSHPIVFG HCVKIYYKEA FEKHGKLFDE LGINVNNGMA
310 320 330 340 350
GLYEKIETLP TSLREEIIED LHACQEHRPA LAMVDSAKGI TNFHSPNDII
360 370 380 390 400
VDASMPAMIR AGGKMWGADG KQYDAKAVMP ESTFARIYQE MINFCKWHGN
410 420 430 440 450
FDPKTMGTVP NVGLMAQKAE EYGSHDKTFE IPEAGIANIT DLDTGEVLLT
460 470 480 490 500
QNVEEGDIWR MCQVKDAPIR DWVKLAVTRA RNSGMPAIFW LDPYRPHENE
510 520 530 540 550
LIKKVQKYLK DHDTTGLDIQ IMSQVRAMRY TLERVVRGLD TISVTGNILR
560 570 580 590 600
DYLTDLFPIM ELGTSAKMLS IVPLMAGGGM YETGAGGSAP KHVQQLVEEN
610 620 630 640 650
HLRWDSLGEF LALAVSLEEM GIKENNARAK LLAKTLDEAT GKLLDNDKSP
660 670 680 690 700
SRRTGELDNR GSHFYLSLYW AEALAAQNED AELKAKFAPL AKALAENEQK
710 720 730 740
IVAELAQVQG KPADIGGYYA VDPAKVSAVM RPSATFNAAL STVQA
Length:745
Mass (Da):82,640
Last modified:April 8, 2008 - v1
Checksum:iF200A5A1C5F29EFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468230 Genomic DNA. Translation: CAP00354.1.
RefSeqiYP_001706521.1. NC_010400.1.

Genome annotation databases

EnsemblBacteriaiCAP00354; CAP00354; ABSDF0995.
GeneIDi5984541.
KEGGiabm:ABSDF0995.
PATRICi20732900. VBIAciBau88365_0972.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468230 Genomic DNA. Translation: CAP00354.1.
RefSeqiYP_001706521.1. NC_010400.1.

3D structure databases

ProteinModelPortaliB0VTR7.
SMRiB0VTR7. Positions 8-741.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi509170.ABSDF0995.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAP00354; CAP00354; ABSDF0995.
GeneIDi5984541.
KEGGiabm:ABSDF0995.
PATRICi20732900. VBIAciBau88365_0972.

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiNSGQMWG.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SDFImported.

Entry informationi

Entry nameiB0VTR7_ACIBS
AccessioniPrimary (citable) accession number: B0VTR7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: March 4, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.