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B0VTE5

- DUT_ACIBS

UniProt

B0VTE5 - DUT_ACIBS

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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene
dut, ABSDF2550
Organism
Acinetobacter baumannii (strain SDF)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821Substrate By similarity
Binding sitei96 – 961Substrate; via amide nitrogen and carbonyl oxygen By similarity

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:dut
Ordered Locus Names:ABSDF2550
OrganismiAcinetobacter baumannii (strain SDF)
Taxonomic identifieri509170 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
ProteomesiUP000001741: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 150150Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotationPRO_1000094936Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi509170.ABSDF2550.

Structurei

3D structure databases

ProteinModelPortaliB0VTE5.
SMRiB0VTE5. Positions 2-137.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni69 – 713Substrate binding By similarity
Regioni86 – 883Substrate binding By similarity

Sequence similaritiesi

Belongs to the dUTPase family.

Phylogenomic databases

eggNOGiCOG0756.
HOGENOMiHOG000028968.
KOiK01520.
OMAiSIYIGDP.
OrthoDBiEOG689HXK.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00116. dUTPase_bact.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

B0VTE5-1 [UniParc]FASTAAdd to Basket

« Hide

MKVQVKLLDP RLGKEWPLPS YATAGSAGLD LRACLDEAIE IEPGQTVLVK    50
TGMAIYIHDV NFAGLILPRS GLGHKHGIVL GNLVGLIDSD YQGELMVSVW 100
NRGQTTFRLE PGERLAQYVL VPVVQAEFEQ VEEFEETLRG AGGFGHTGKQ 150
Length:150
Mass (Da):16,371
Last modified:June 10, 2008 - v1
Checksum:iF3EBE361AA5BE853
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU468230 Genomic DNA. Translation: CAP01860.1.
RefSeqiYP_001707775.1. NC_010400.1.

Genome annotation databases

EnsemblBacteriaiCAP01860; CAP01860; ABSDF2550.
GeneIDi5986528.
KEGGiabm:ABSDF2550.
PATRICi20735823. VBIAciBau88365_2418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU468230 Genomic DNA. Translation: CAP01860.1 .
RefSeqi YP_001707775.1. NC_010400.1.

3D structure databases

ProteinModelPortali B0VTE5.
SMRi B0VTE5. Positions 2-137.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 509170.ABSDF2550.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP01860 ; CAP01860 ; ABSDF2550 .
GeneIDi 5986528.
KEGGi abm:ABSDF2550.
PATRICi 20735823. VBIAciBau88365_2418.

Phylogenomic databases

eggNOGi COG0756.
HOGENOMi HOG000028968.
KOi K01520.
OMAi SIYIGDP.
OrthoDBi EOG689HXK.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
HAMAPi MF_00116. dUTPase_bact.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
TIGRFAMsi TIGR00576. dut. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SDF.

Entry informationi

Entry nameiDUT_ACIBS
AccessioniPrimary (citable) accession number: B0VTE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: June 11, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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