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B0VST3

- BETA_ACIBS

UniProt

B0VST3 - BETA_ACIBS

Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Acinetobacter baumannii (strain SDF)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

    Catalytic activityi

    Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei477 – 4771UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 3630FADUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
    2. choline dehydrogenase activity Source: UniProtKB-HAMAP
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    UniPathwayiUPA00529; UER00385.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
    Short name:
    CDHUniRule annotation
    Short name:
    CHDUniRule annotation
    Alternative name(s):
    Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betAUniRule annotation
    Ordered Locus Names:ABSDF2440
    OrganismiAcinetobacter baumannii (strain SDF)
    Taxonomic identifieri509170 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
    ProteomesiUP000001741: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 552552Oxygen-dependent choline dehydrogenasePRO_1000133318Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi509170.ABSDF2440.

    Structurei

    3D structure databases

    ProteinModelPortaliB0VST3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GMC oxidoreductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2303.
    HOGENOMiHOG000139600.
    KOiK00108.
    OMAiYLQYACT.
    OrthoDBiEOG67HJQP.

    Family and domain databases

    HAMAPiMF_00750. Choline_dehydrogen.
    InterProiIPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view]
    PfamiPF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsiTIGR01810. betA. 1 hit.
    PROSITEiPS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0VST3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNIKEYDYII IGAGSAGNVL AARLTEDKDT TVLLLEAGGP DYRLDFRTQM    50
    PAALAYPLQG RRYNWAYLTD PEPHMNNRRM ECGRGKGLGG SSLINGMCYI 100
    RGNAMDLEQW ATHKGLENWT YADCLPYYKK AETRDIGGND YHGDSGPVSV 150
    ATPKNGNNVL FHAMVEAGVQ AGYPRTDDLN GYQQEGFGPM DRTVTPKGRR 200
    SSTARGYLDM AKGRPNLTIL THATTNKILF NQKQAIGVEY IIGADQNNLQ 250
    RALVKREVLL CAGAIASPQI LQRSGVGQST FLKSMDIDVV HDLPGVGENL 300
    QDHLEMYLQY KCKQPVSLYP ALKWYNQPAI GAEWLFNGTG IGASNQFEAG 350
    GFIRSSDEFK WPNIQYHFLP VAINYNGSNA VKEHGFQAHV GSMRSPSRGR 400
    IKLKSKDPFA HPSILFNYMS TEQDWREFRD AIRITREIMH QPALDPYRGD 450
    EISPGKHLQT DAELDDFVRN HAETAYHPSC SCKMGEDEMA VVDGQGRVHG 500
    MNGLRVVDAS IMPLIITGNL NATTIMIAEK IADQIRGREA LPRSTAPFYV 550
    AS 552
    Length:552
    Mass (Da):61,302
    Last modified:June 10, 2008 - v1
    Checksum:iB1B3FF7E0172F7FD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU468230 Genomic DNA. Translation: CAP01751.1.
    RefSeqiYP_001707680.1. NC_010400.1.

    Genome annotation databases

    EnsemblBacteriaiCAP01751; CAP01751; ABSDF2440.
    GeneIDi5986597.
    KEGGiabm:ABSDF2440.
    PATRICi20735619. VBIAciBau88365_2317.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU468230 Genomic DNA. Translation: CAP01751.1 .
    RefSeqi YP_001707680.1. NC_010400.1.

    3D structure databases

    ProteinModelPortali B0VST3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 509170.ABSDF2440.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAP01751 ; CAP01751 ; ABSDF2440 .
    GeneIDi 5986597.
    KEGGi abm:ABSDF2440.
    PATRICi 20735619. VBIAciBau88365_2317.

    Phylogenomic databases

    eggNOGi COG2303.
    HOGENOMi HOG000139600.
    KOi K00108.
    OMAi YLQYACT.
    OrthoDBi EOG67HJQP.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00385 .

    Family and domain databases

    HAMAPi MF_00750. Choline_dehydrogen.
    InterProi IPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view ]
    Pfami PF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsi TIGR01810. betA. 1 hit.
    PROSITEi PS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SDF.

    Entry informationi

    Entry nameiBETA_ACIBS
    AccessioniPrimary (citable) accession number: B0VST3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3