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B0VSN6

- PCKG_ACIBS

UniProt

B0VSN6 - PCKG_ACIBS

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Protein
Phosphoenolpyruvate carboxykinase [GTP]
Gene
pckG, ABSDF0809
Organism
Acinetobacter baumannii (strain SDF)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle By similarity.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarity
Binding sitei218 – 2181Substrate; via amide nitrogen By similarity
Metal bindingi225 – 2251Manganese By similarity
Binding sitei225 – 2251Substrate By similarity
Metal bindingi245 – 2451Manganese; via tele nitrogen By similarity
Binding sitei267 – 2671Substrate By similarity
Active sitei269 – 2691 By similarity
Metal bindingi294 – 2941Manganese By similarity
Binding sitei384 – 3841GTP By similarity
Binding sitei415 – 4151GTP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi268 – 2736GTP By similarity
Nucleotide bindingi516 – 5194GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP] (EC:4.1.1.32)
Short name:
PEP carboxykinase
Short name:
PEPCK
Gene namesi
Name:pckG
Ordered Locus Names:ABSDF0809
OrganismiAcinetobacter baumannii (strain SDF)
Taxonomic identifieri509170 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
ProteomesiUP000001741: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 610610Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation
PRO_1000125040Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi509170.ABSDF0809.

Structurei

3D structure databases

ProteinModelPortaliB0VSN6.
SMRiB0VSN6. Positions 10-604.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni382 – 3843Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1274.
HOGENOMiHOG000191700.
KOiK01596.
OMAiWDNPAGV.
OrthoDBiEOG6MPWQS.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00505. PEPCK_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0VSN6-1 [UniParc]FASTAAdd to Basket

« Hide

MTTVNAPEFV RHPKLIAWVE EIANLTKPAK IEWCDGSEEE YQRLIDLMIA    50
NGTMQKLNQE KHPGSYLANS DPSDVARVED RTYICSQNKE DAGATNNWED 100
PAVMREKLNG LFEGSMKGRT MYVVPFSMGP LGSHIAHIGI ELTDSPYVAV 150
SMRKMARMGK AVYDVLGTDG EFVPCVHTVG APLAEGQKDV AWPCNPEKYI 200
VHYPETREIW SFGSGYGGNA LLGKKCLALR IASVMGREQG WLAEHMLILG 250
VTNPQGEKHY IAAAFPSACG KTNFAMLIPP AGYEGWKIET VGDDIAWIKP 300
GEDGRLYAIN PEAGFFGVAP GTNTKTNPNC MATLHKDVIY TNVAVTDDGQ 350
VWWEGLSKEV PANLTNWKGQ PHVNGEKAAH PNARFTVAAG QCPSIDADWE 400
NPAGVPISAF IFGGRRADTV PLVSEAFDWV DGVYKAATMG SETTAAAVGQ 450
QGIVRRDPFA MLPFAGYNMA DYFDHWLNLG AKVSEKAEAS GNKLPKIFNV 500
NWFRRDAEGN FVWPGFGQNM RVLEWIIDRC EGRANAVETP IGFVPTYEDL 550
NWEGTEFTKE QFDLITNQDK DQWVTEIESH TELFNKLGER LPKALKERQA 600
ALLEAVKTGF 610
Length:610
Mass (Da):67,420
Last modified:April 8, 2008 - v1
Checksum:i7162A1DF31AD796E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU468230 Genomic DNA. Translation: CAP00176.1.
RefSeqiYP_001706385.1. NC_010400.1.

Genome annotation databases

EnsemblBacteriaiCAP00176; CAP00176; ABSDF0809.
GeneIDi5986818.
KEGGiabm:ABSDF0809.
PATRICi20732547. VBIAciBau88365_0797.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU468230 Genomic DNA. Translation: CAP00176.1 .
RefSeqi YP_001706385.1. NC_010400.1.

3D structure databases

ProteinModelPortali B0VSN6.
SMRi B0VSN6. Positions 10-604.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 509170.ABSDF0809.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP00176 ; CAP00176 ; ABSDF0809 .
GeneIDi 5986818.
KEGGi abm:ABSDF0809.
PATRICi 20732547. VBIAciBau88365_0797.

Phylogenomic databases

eggNOGi COG1274.
HOGENOMi HOG000191700.
KOi K01596.
OMAi WDNPAGV.
OrthoDBi EOG6MPWQS.

Enzyme and pathway databases

UniPathwayi UPA00138 .

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
PROSITEi PS00505. PEPCK_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SDF.

Entry informationi

Entry nameiPCKG_ACIBS
AccessioniPrimary (citable) accession number: B0VSN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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