Reviewed, UniProtKB/Swiss-Prot B0VQ34 (AROB_ACIBS)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	ABSDF0302

Organism

Acinetobacter baumannii (strain SDF) [Complete proteome] [HAMAP]

Taxonomic identifier

509170 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. HAMAP MF_00110 NAD By similarity. HAMAP MF_00110
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity. HAMAP MF_00110
Subcellular location	Cytoplasm By similarity HAMAP MF_00110.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 360	360	3-dehydroquinate synthase HAMAP MF_00110		PRO_1000094440

Sequences

	Sequence		Length	Mass (Da)
	B0VQ34-1 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: F0DF2C4C69E40AE8	FASTA	360	39,467
	10 20 30 40 50 60 MQTLHVELGE RRYPIFIGSQ LDPKQLLEPY IHGQQVMIVS NVTVAPLYLS HYQEALESLG 70 80 90 100 110 120 KTVATCILPD GEKYKDIQHL NLIFDALLEA GFNRDCTVLA LGGGVIGDMA GFASACFQRG 130 140 150 160 170 180 VYFVQVPTTL LSQVDSSVGG KTGINHPLGK NMLGAFQQPQ VVLADMAQLN TLPERELSAG 190 200 210 220 230 240 LAEVIKYALL GDEDFLVWLE ENMDGLVARD ADLLAEAVYR SCAHKARIVA NDEKEQGERA 250 260 270 280 290 300 LLNLGHTFGH AIESYLGYGT WLHGEAVATG MVMAADLSQR LGWISNEDVA RTKKIIQRAN 310 320 330 340 350 360 LPISCPQIPL DDFLGHMAHD KKVLNGQLRL VLLKQLGQAV ITKDFDVELM KQAILANQHG

References

[1]

"Comparative analysis of Acinetobacters: three genomes for three lifestyles." Vallenet D., Nordmann P., Barbe V., Poirel L., Mangenot S., Bataille E., Dossat C., Gas S., Kreimeyer A., Lenoble P., Oztas S., Poulain J., Segurens B., Robert C., Abergel C., Claverie J.-M., Raoult D., Medigue C., Weissenbach J., Cruveiller S. PLoS ONE 3:E1805-E1805(2008) [PubMed: 18350144] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU468230 Genomic DNA. Translation: CAO99697.1.
RefSeq	YP_001705988.1.
3D structure databases
SMR	B0VQ34. Positions 12-351.
ModBase	Search...
Genome annotation databases
GeneID	5986563.
GenomeReviews	Gene locus ABSDF0302 in contig CU468230_GR.
KEGG	abm:ABSDF0302.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG632303.
OMA	APESMDF.
Family and domain databases
HAMAP	MF_00110. DHQ_synthase. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_ACIBS

Accession

Primary (citable) accession number: B0VQ34

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 8, 2008
Last modified:	February 9, 2010
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)