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B0VMV2

- LPXD_ACIBS

UniProt

B0VMV2 - LPXD_ACIBS

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Protein
UDP-3-O-acylglucosamine N-acyltransferase
Gene
lpxD, ABSDF1688
Organism
Acinetobacter baumannii (strain SDF)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein].UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei242 – 2421Proton acceptor By similarity

GO - Molecular functioni

  1. transferase activity, transferring acyl groups other than amino-acyl groups Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00973.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-3-O-acylglucosamine N-acyltransferase (EC:2.3.1.-)
Gene namesi
Name:lpxD
Ordered Locus Names:ABSDF1688
OrganismiAcinetobacter baumannii (strain SDF)
Taxonomic identifieri509170 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
ProteomesiUP000001741: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356UDP-3-O-acylglucosamine N-acyltransferaseUniRule annotation
PRO_1000127656Add
BLAST

Interactioni

Subunit structurei

Homotrimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi509170.ABSDF1688.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 147
Beta strandi18 – 214
Turni33 – 353
Beta strandi40 – 434
Helixi47 – 493
Helixi50 – 556
Beta strandi59 – 635
Helixi65 – 695
Beta strandi76 – 794
Helixi83 – 919
Beta strandi180 – 1823
Beta strandi188 – 1914
Beta strandi194 – 1974
Beta strandi204 – 2063
Beta strandi222 – 2243
Beta strandi226 – 2283
Beta strandi284 – 2885
Beta strandi302 – 3054
Helixi313 – 32614
Helixi333 – 34614

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4E75X-ray2.85A/B/C/D/E/F2-355[»]
4E79X-ray2.66A/B/C2-355[»]
ProteinModelPortaliB0VMV2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1044.
HOGENOMiHOG000294339.
KOiK02536.
OMAiWANVTLY.
OrthoDBiEOG6JB11D.

Family and domain databases

HAMAPiMF_00523. LpxD.
InterProiIPR001451. Hexapep_transf.
IPR011004. Trimer_LpxA-like.
IPR007691. UDP-3-O_GlcNAc_AcTrfase.
IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
[Graphical view]
PfamiPF00132. Hexapep. 3 hits.
PF04613. LpxD. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR01853. lipid_A_lpxD. 1 hit.

Sequencei

Sequence statusi: Complete.

B0VMV2-1 [UniParc]FASTAAdd to Basket

« Hide

MKVQQYRLDE LAHLVKGELI GEGSLQFSNL ASLENAEVNH LTFVNGEKHL    50
DQAKVSRAGA YIVTAALKEH LPEKDNFIIV DNPYLAFAIL THVFDKKISS 100
TGIESTARIH PSAVISETAY IGHYVVIGEN CVVGDNTVIQ SHTKLDDNVE 150
VGKDCFIDSY VTITGSSKLR DRVRIHSSTV IGGEGFGFAP YQGKWHRIAQ 200
LGSVLIGNDV RIGSNCSIDR GALDNTILED GVIIDNLVQI AHNVHIGSNT 250
AIAAKCGIAG STKIGKNCIL AGACGVAGHL SIADNVTLTG MSMVTKNISE 300
AGTYSSGTGL FENNHWKKTI VRLRQLADVP LTQITKRLDH IQAQIESLES 350
TFNLRK 356
Length:356
Mass (Da):38,484
Last modified:April 8, 2008 - v1
Checksum:iBF15F948205840F6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU468230 Genomic DNA. Translation: CAP01028.1.
RefSeqiYP_001707073.1. NC_010400.1.

Genome annotation databases

EnsemblBacteriaiCAP01028; CAP01028; ABSDF1688.
GeneIDi5985058.
KEGGiabm:ABSDF1688.
PATRICi20734219. VBIAciBau88365_1620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU468230 Genomic DNA. Translation: CAP01028.1 .
RefSeqi YP_001707073.1. NC_010400.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4E75 X-ray 2.85 A/B/C/D/E/F 2-355 [» ]
4E79 X-ray 2.66 A/B/C 2-355 [» ]
ProteinModelPortali B0VMV2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 509170.ABSDF1688.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP01028 ; CAP01028 ; ABSDF1688 .
GeneIDi 5985058.
KEGGi abm:ABSDF1688.
PATRICi 20734219. VBIAciBau88365_1620.

Phylogenomic databases

eggNOGi COG1044.
HOGENOMi HOG000294339.
KOi K02536.
OMAi WANVTLY.
OrthoDBi EOG6JB11D.

Enzyme and pathway databases

UniPathwayi UPA00973 .

Family and domain databases

HAMAPi MF_00523. LpxD.
InterProi IPR001451. Hexapep_transf.
IPR011004. Trimer_LpxA-like.
IPR007691. UDP-3-O_GlcNAc_AcTrfase.
IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
[Graphical view ]
Pfami PF00132. Hexapep. 3 hits.
PF04613. LpxD. 1 hit.
[Graphical view ]
SUPFAMi SSF51161. SSF51161. 1 hit.
TIGRFAMsi TIGR01853. lipid_A_lpxD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SDF.

Entry informationi

Entry nameiLPXD_ACIBS
AccessioniPrimary (citable) accession number: B0VMV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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