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B0VMV2 (LPXD_ACIBS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-3-O-acylglucosamine N-acyltransferase
EC=2.3.1.-
Gene names
Name:lpxD
Ordered Locus Names:ABSDF1688
OrganismAcinetobacter baumannii (strain SDF) [Complete proteome] [HAMAP]
Taxonomic identifier509170 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex ›

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00523

Catalytic activity

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein]. HAMAP-Rule MF_00523

Pathway

Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. HAMAP-Rule MF_00523

Subunit structure

Homotrimer By similarity.

Sequence similarities

Belongs to the transferase hexapeptide repeat family. LpxD subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356UDP-3-O-acylglucosamine N-acyltransferase HAMAP-Rule MF_00523
PRO_1000127656

Sites

Active site2421Proton acceptor By similarity

Secondary structure

1 ........................................ 356
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
B0VMV2 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: BF15F948205840F6

FASTA35638,484
        10         20         30         40         50         60 
MKVQQYRLDE LAHLVKGELI GEGSLQFSNL ASLENAEVNH LTFVNGEKHL DQAKVSRAGA 

        70         80         90        100        110        120 
YIVTAALKEH LPEKDNFIIV DNPYLAFAIL THVFDKKISS TGIESTARIH PSAVISETAY 

       130        140        150        160        170        180 
IGHYVVIGEN CVVGDNTVIQ SHTKLDDNVE VGKDCFIDSY VTITGSSKLR DRVRIHSSTV 

       190        200        210        220        230        240 
IGGEGFGFAP YQGKWHRIAQ LGSVLIGNDV RIGSNCSIDR GALDNTILED GVIIDNLVQI 

       250        260        270        280        290        300 
AHNVHIGSNT AIAAKCGIAG STKIGKNCIL AGACGVAGHL SIADNVTLTG MSMVTKNISE 

       310        320        330        340        350 
AGTYSSGTGL FENNHWKKTI VRLRQLADVP LTQITKRLDH IQAQIESLES TFNLRK

« Hide

References

[1]"Comparative analysis of Acinetobacters: three genomes for three lifestyles."
Vallenet D., Nordmann P., Barbe V., Poirel L., Mangenot S., Bataille E., Dossat C., Gas S., Kreimeyer A., Lenoble P., Oztas S., Poulain J., Segurens B., Robert C., Abergel C., Claverie J.-M., Raoult D., Medigue C., Weissenbach J., Cruveiller S.
PLoS ONE 3:E1805-E1805(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SDF.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU468230 Genomic DNA. Translation: CAP01028.1.
RefSeqYP_001707073.1. NC_010400.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4E75X-ray2.85A/B/C/D/E/F2-355[»]
4E79X-ray2.66A/B/C2-355[»]
ProteinModelPortalB0VMV2.
ModBaseSearch...

Protein-protein interaction databases

STRING509170.ABSDF1688.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAP01028; CAP01028; ABSDF1688.
GeneID5985058.
KEGGabm:ABSDF1688.
PATRIC20734219. VBIAciBau88365_1620.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1044.
HOGENOMHOG000294339.
KOK02536.
OMACLIAAQC.
ProtClustDBPRK00892.

Enzyme and pathway databases

UniPathwayUPA00973.

Family and domain databases

HAMAPMF_00523. LpxD.
InterProIPR001451. Hexapep_transf.
IPR011004. Trimer_LpxA-like.
IPR007691. UDP-3-O_GlcNAc_AcTrfase.
IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
[Graphical view]
PfamPF00132. Hexapep. 3 hits.
PF04613. LpxD. 1 hit.
[Graphical view]
SUPFAMSSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMsTIGR01853. lipid_A_lpxD. 1 hit.
PROSITEPS00101. HEXAPEP_TRANSFERASES. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLPXD_ACIBS
AccessionPrimary (citable) accession number: B0VMV2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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