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B0VMV2

- LPXD_ACIBS

UniProt

B0VMV2 - LPXD_ACIBS

Protein

UDP-3-O-acylglucosamine N-acyltransferase

Gene

lpxD

Organism
Acinetobacter baumannii (strain SDF)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    (3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein].UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei242 – 2421Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. transferase activity, transferring acyl groups other than amino-acyl groups Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00973.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-3-O-acylglucosamine N-acyltransferaseUniRule annotation (EC:2.3.1.-UniRule annotation)
    Gene namesi
    Name:lpxDUniRule annotation
    Ordered Locus Names:ABSDF1688
    OrganismiAcinetobacter baumannii (strain SDF)
    Taxonomic identifieri509170 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
    ProteomesiUP000001741: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 356356UDP-3-O-acylglucosamine N-acyltransferasePRO_1000127656Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi509170.ABSDF1688.

    Structurei

    Secondary structure

    1
    356
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi8 – 147
    Beta strandi18 – 214
    Turni33 – 353
    Beta strandi40 – 434
    Helixi47 – 493
    Helixi50 – 556
    Beta strandi59 – 635
    Helixi65 – 695
    Beta strandi76 – 794
    Helixi83 – 919
    Beta strandi180 – 1823
    Beta strandi188 – 1914
    Beta strandi194 – 1974
    Beta strandi204 – 2063
    Beta strandi222 – 2243
    Beta strandi226 – 2283
    Beta strandi284 – 2885
    Beta strandi302 – 3054
    Helixi313 – 32614
    Helixi333 – 34614

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4E75X-ray2.85A/B/C/D/E/F2-355[»]
    4E79X-ray2.66A/B/C2-355[»]
    ProteinModelPortaliB0VMV2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transferase hexapeptide repeat family. LpxD subfamily.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1044.
    HOGENOMiHOG000294339.
    KOiK02536.
    OMAiWANVTLY.
    OrthoDBiEOG6JB11D.

    Family and domain databases

    HAMAPiMF_00523. LpxD.
    InterProiIPR001451. Hexapep_transf.
    IPR011004. Trimer_LpxA-like.
    IPR007691. UDP-3-O_GlcNAc_AcTrfase.
    IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
    [Graphical view]
    PfamiPF00132. Hexapep. 3 hits.
    PF04613. LpxD. 1 hit.
    [Graphical view]
    SUPFAMiSSF51161. SSF51161. 1 hit.
    TIGRFAMsiTIGR01853. lipid_A_lpxD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B0VMV2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVQQYRLDE LAHLVKGELI GEGSLQFSNL ASLENAEVNH LTFVNGEKHL    50
    DQAKVSRAGA YIVTAALKEH LPEKDNFIIV DNPYLAFAIL THVFDKKISS 100
    TGIESTARIH PSAVISETAY IGHYVVIGEN CVVGDNTVIQ SHTKLDDNVE 150
    VGKDCFIDSY VTITGSSKLR DRVRIHSSTV IGGEGFGFAP YQGKWHRIAQ 200
    LGSVLIGNDV RIGSNCSIDR GALDNTILED GVIIDNLVQI AHNVHIGSNT 250
    AIAAKCGIAG STKIGKNCIL AGACGVAGHL SIADNVTLTG MSMVTKNISE 300
    AGTYSSGTGL FENNHWKKTI VRLRQLADVP LTQITKRLDH IQAQIESLES 350
    TFNLRK 356
    Length:356
    Mass (Da):38,484
    Last modified:April 8, 2008 - v1
    Checksum:iBF15F948205840F6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU468230 Genomic DNA. Translation: CAP01028.1.
    RefSeqiYP_001707073.1. NC_010400.1.

    Genome annotation databases

    EnsemblBacteriaiCAP01028; CAP01028; ABSDF1688.
    GeneIDi5985058.
    KEGGiabm:ABSDF1688.
    PATRICi20734219. VBIAciBau88365_1620.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU468230 Genomic DNA. Translation: CAP01028.1 .
    RefSeqi YP_001707073.1. NC_010400.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4E75 X-ray 2.85 A/B/C/D/E/F 2-355 [» ]
    4E79 X-ray 2.66 A/B/C 2-355 [» ]
    ProteinModelPortali B0VMV2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 509170.ABSDF1688.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAP01028 ; CAP01028 ; ABSDF1688 .
    GeneIDi 5985058.
    KEGGi abm:ABSDF1688.
    PATRICi 20734219. VBIAciBau88365_1620.

    Phylogenomic databases

    eggNOGi COG1044.
    HOGENOMi HOG000294339.
    KOi K02536.
    OMAi WANVTLY.
    OrthoDBi EOG6JB11D.

    Enzyme and pathway databases

    UniPathwayi UPA00973 .

    Family and domain databases

    HAMAPi MF_00523. LpxD.
    InterProi IPR001451. Hexapep_transf.
    IPR011004. Trimer_LpxA-like.
    IPR007691. UDP-3-O_GlcNAc_AcTrfase.
    IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
    [Graphical view ]
    Pfami PF00132. Hexapep. 3 hits.
    PF04613. LpxD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51161. SSF51161. 1 hit.
    TIGRFAMsi TIGR01853. lipid_A_lpxD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SDF.

    Entry informationi

    Entry nameiLPXD_ACIBS
    AccessioniPrimary (citable) accession number: B0VMV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3