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Protein

UDP-3-O-acylglucosamine N-acyltransferase

Gene

lpxD

Organism
Acinetobacter baumannii (strain SDF)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein].UniRule annotation

Pathwayi: LPS lipid A biosynthesis

This protein is involved in the pathway LPS lipid A biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway LPS lipid A biosynthesis and in Bacterial outer membrane biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei242Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00973.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-3-O-acylglucosamine N-acyltransferaseUniRule annotation (EC:2.3.1.-UniRule annotation)
Gene namesi
Name:lpxDUniRule annotation
Ordered Locus Names:ABSDF1688
OrganismiAcinetobacter baumannii (strain SDF)
Taxonomic identifieri509170 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
Proteomesi
  • UP000001741 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001276561 – 356UDP-3-O-acylglucosamine N-acyltransferaseAdd BLAST356

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Structurei

Secondary structure

1356
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 14Combined sources7
Beta strandi18 – 21Combined sources4
Turni33 – 35Combined sources3
Beta strandi40 – 43Combined sources4
Helixi47 – 49Combined sources3
Helixi50 – 55Combined sources6
Beta strandi59 – 63Combined sources5
Helixi65 – 69Combined sources5
Beta strandi76 – 79Combined sources4
Helixi83 – 91Combined sources9
Beta strandi180 – 182Combined sources3
Beta strandi188 – 191Combined sources4
Beta strandi194 – 197Combined sources4
Beta strandi204 – 206Combined sources3
Beta strandi222 – 224Combined sources3
Beta strandi226 – 228Combined sources3
Beta strandi284 – 288Combined sources5
Beta strandi302 – 305Combined sources4
Helixi313 – 326Combined sources14
Helixi333 – 346Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4E75X-ray2.85A/B/C/D/E/F2-355[»]
4E79X-ray2.66A/B/C2-355[»]
ProteinModelPortaliB0VMV2.
SMRiB0VMV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family. LpxD subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000294339.
KOiK02536.
OMAiSYPAKIM.

Family and domain databases

CDDicd03352. LbH_LpxD. 1 hit.
HAMAPiMF_00523. LpxD. 1 hit.
InterProiIPR001451. Hexapep.
IPR007691. LpxD.
IPR011004. Trimer_LpxA-like.
IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
[Graphical view]
PfamiPF00132. Hexapep. 3 hits.
PF14602. Hexapep_2. 1 hit.
PF04613. LpxD. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR01853. lipid_A_lpxD. 1 hit.

Sequencei

Sequence statusi: Complete.

B0VMV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVQQYRLDE LAHLVKGELI GEGSLQFSNL ASLENAEVNH LTFVNGEKHL
60 70 80 90 100
DQAKVSRAGA YIVTAALKEH LPEKDNFIIV DNPYLAFAIL THVFDKKISS
110 120 130 140 150
TGIESTARIH PSAVISETAY IGHYVVIGEN CVVGDNTVIQ SHTKLDDNVE
160 170 180 190 200
VGKDCFIDSY VTITGSSKLR DRVRIHSSTV IGGEGFGFAP YQGKWHRIAQ
210 220 230 240 250
LGSVLIGNDV RIGSNCSIDR GALDNTILED GVIIDNLVQI AHNVHIGSNT
260 270 280 290 300
AIAAKCGIAG STKIGKNCIL AGACGVAGHL SIADNVTLTG MSMVTKNISE
310 320 330 340 350
AGTYSSGTGL FENNHWKKTI VRLRQLADVP LTQITKRLDH IQAQIESLES

TFNLRK
Length:356
Mass (Da):38,484
Last modified:April 8, 2008 - v1
Checksum:iBF15F948205840F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468230 Genomic DNA. Translation: CAP01028.1.

Genome annotation databases

EnsemblBacteriaiCAP01028; CAP01028; ABSDF1688.
KEGGiabm:ABSDF1688.
PATRICi20734219. VBIAciBau88365_1620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468230 Genomic DNA. Translation: CAP01028.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4E75X-ray2.85A/B/C/D/E/F2-355[»]
4E79X-ray2.66A/B/C2-355[»]
ProteinModelPortaliB0VMV2.
SMRiB0VMV2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAP01028; CAP01028; ABSDF1688.
KEGGiabm:ABSDF1688.
PATRICi20734219. VBIAciBau88365_1620.

Phylogenomic databases

HOGENOMiHOG000294339.
KOiK02536.
OMAiSYPAKIM.

Enzyme and pathway databases

UniPathwayiUPA00973.

Family and domain databases

CDDicd03352. LbH_LpxD. 1 hit.
HAMAPiMF_00523. LpxD. 1 hit.
InterProiIPR001451. Hexapep.
IPR007691. LpxD.
IPR011004. Trimer_LpxA-like.
IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
[Graphical view]
PfamiPF00132. Hexapep. 3 hits.
PF14602. Hexapep_2. 1 hit.
PF04613. LpxD. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR01853. lipid_A_lpxD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLPXD_ACIBS
AccessioniPrimary (citable) accession number: B0VMV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: November 2, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.