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Reviewed, UniProtKB/Swiss-Prot B0VMM0 (LSPA_ACIBS)

Last modified November 3, 2009. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Lipoprotein signal peptidase
    EC=3.4.23.36
Alternative name(s):
    Prolipoprotein signal peptidase
    Signal peptidase II
      Short name=SPase II
Gene names
Name: lspA
Ordered Locus Names: ABSDF0026
OrganismAcinetobacter baumannii (strain SDF) [Complete proteome] [HAMAP]
Taxonomic identifier509170 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

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Protein attributes

Sequence length176 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

This protein specifically catalyzes the removal of signal peptides from prolipoproteins By similarity.

Catalytic activity

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains. HAMAP MF_00161

Pathway

Protein modification; lipoprotein biosynthesis (signal peptide cleavage). HAMAP MF_00161

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the peptidase A8 family.

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Ontologies

Keywords
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
   Molecular functionAspartyl protease
Hydrolase
Protease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: HAMAP

   Molecular functionaspartic-type endopeptidase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 176176Lipoprotein signal peptidase HAMAP MF_00161
PRO_1000097225

Regions

Transmembrane10 – 3021 Potential
Transmembrane48 – 6821 Potential
Transmembrane78 – 9821 Potential
Transmembrane102 – 12221 Potential
Transmembrane141 – 16121 Potential

Sites

Active site1221 By similarity
Active site1491 By similarity

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Sequences

Sequence LengthMass (Da)Tools
B0VMM0-1 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: CF55C08C4676E4FF

FASTA17619,929
        10         20         30         40         50         60 
MPNSQAKKGL FQFYPHNLIW LGLSVLAIVL DQWTKWIAST HMNYADPVPV LPFLNWTLLH 

        70         80         90        100        110        120 
NYGAAFSFLS DAGGWQRYFF TSLAGLVSIL FVFWLLRMPK KMVVLPVAIA LILGGALGNL 

       130        140        150        160        170 
IDRITLGYVV DFIHVYYQNH HFPAFNIADS AITLGTILLL IDTFFLEKQR PKNSDA

« Hide

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References

[1]"Comparative analysis of Acinetobacters: three genomes for three lifestyles."
Vallenet D., Nordmann P., Barbe V., Poirel L., Mangenot S., Bataille E., Dossat C., Gas S., Kreimeyer A., Lenoble P., Oztas S., Poulain J., Segurens B., Robert C., Abergel C., Claverie J.-M., Raoult D., Medigue C., Weissenbach J., Cruveiller S.
PLoS ONE 3:E1805-E1805(2008) [PubMed: 18350144] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CU468230 Genomic DNA. Translation: CAO99442.1.
RefSeqYP_001705783.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID5986762.
GenomeReviewsGene locus ABSDF0026 in contig CU468230_GR.
KEGGabm:ABSDF0026.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMASMKVGDS.

Family and domain databases

HAMAPMF_00161.
[Tree]
InterProIPR001872. Peptidase_A8.
[Graphical view]
PfamPF01252. Peptidase_A8. 1 hit.
[Graphical view]
PRINTSPR00781. LIPOSIGPTASE.
ProDomPD004304. Peptidase_A8. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR00077. lspA. 1 hit.
PROSITEPS00855. SPASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameLSPA_ACIBS
AccessionPrimary (citable) accession number: B0VMM0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: November 3, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents