B0VMJ8 (B0VMJ8_ACIBS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Aquaporin Z HAMAP-Rule MF_01146

Gene names

Name:	aqpZ HAMAP-Rule MF_01146 EMBL CAP02612.1
Ordered Locus Names:	ABSDF3343 EMBL CAP02612.1

Organism

Acinetobacter baumannii (strain SDF) [Complete proteome] [HAMAP]

Taxonomic identifier

509170 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex › Acinetobacter baumannii

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity By similarity. HAMAP-Rule MF_01146
Subunit structure	Homotetramer By similarity. HAMAP-Rule MF_01146
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01146.
Domain	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA) By similarity. HAMAP-Rule MF_01146
Sequence similarities	Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification] HAMAP-Rule MF_01146

Ontologies

Keywords
Biological process	Transport HAMAP-Rule MF_01146
Cellular component	Cell inner membrane HAMAP-Rule MF_01146 Cell membrane Membrane
Domain	Repeat HAMAP-Rule MF_01146 Transmembrane Transmembrane helix HAMAP-Rule MF_01146
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	water channel activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Transmembrane	1 – 21	21	Helical; By similarity HAMAP-Rule MF_01146
	Transmembrane	22 – 42	21	Helical; By similarity HAMAP-Rule MF_01146
	Transmembrane	81 – 101	21	Helical; By similarity HAMAP-Rule MF_01146
	Transmembrane	127 – 147	21	Helical; By similarity HAMAP-Rule MF_01146
	Transmembrane	158 – 178	21	Helical; By similarity HAMAP-Rule MF_01146
	Transmembrane	200 – 220	21	Helical; By similarity HAMAP-Rule MF_01146
	Motif	62 – 64	3	NPA 1 By similarity HAMAP-Rule MF_01146
	Motif	184 – 186	3	NPA 2 By similarity HAMAP-Rule MF_01146
Sites
	Site	19	1	Involved in tetramerization or stability of the tetramer By similarity HAMAP-Rule MF_01146
	Site	42	1	Selectivity filter By similarity HAMAP-Rule MF_01146
	Site	172	1	Selectivity filter By similarity HAMAP-Rule MF_01146
	Site	181	1	Selectivity filter By similarity HAMAP-Rule MF_01146
	Site	187	1	Selectivity filter By similarity HAMAP-Rule MF_01146

Sequences

	Sequence		Length	Mass (Da)
	B0VMJ8 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: E6CB05D97950F795	FASTA	229	23,443
	10 20 30 40 50 60 MNKYFAEFLG TFWLVFGGCG SAVLAAAFPE LGIGFAGVAL AFGLTVLTGA YALGHISGGH 70 80 90 100 110 120 FNPAVSVGLW VGGRFDVKDL IPYIVAQVVG ATAAAFVLYI IAQGQAGFSG VGGFAANGFG 130 140 150 160 170 180 DLSPNKFGLG SAFIIEVVLT AFFLIIILGA TDRRAPAGFA PIAIGLGLTL IHLISIPVTN 190 200 210 220 TSVNPARSTG VAFFAETAAL SQLWLFWVAP ILGAVIGAII YKVVAGDKD

References

[1]

"Comparative analysis of Acinetobacters: three genomes for three lifestyles." Vallenet D., Nordmann P., Barbe V., Poirel L., Mangenot S., Bataille E., Dossat C., Gas S., Kreimeyer A., Lenoble P., Oztas S., Poulain J., Segurens B., Robert C., Abergel C., Claverie J.-M., Raoult D., Medigue C., Weissenbach J., Cruveiller S. PLoS ONE 3:e1805-e1805(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SDF EMBL CAP02612.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU468230 Genomic DNA. Translation: CAP02612.1.
RefSeq	YP_001708412.1. NC_010400.1.
3D structure databases
ProteinModelPortal	B0VMJ8.
SMR	B0VMJ8. Positions 3-229.
ModBase	Search...
Protein-protein interaction databases
STRING	509170.ABSDF3343.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAP02612; CAP02612; ABSDF3343.
GeneID	5986174.
KEGG	abm:ABSDF3343.
PATRIC	20737366. VBIAciBau88365_3158.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0580.
HOGENOM	HOG000288286.
KO	K06188.
OMA	EIVMTLF.
ProtClustDB	CLSK2322797.
Family and domain databases
Gene3D	1.20.1080.10. 1 hit.
HAMAP	MF_01146. Aquaporin_Z.
InterPro	IPR023271. Aquaporin-like. IPR023743. Aquaporin_Z. IPR000425. MIP. IPR022357. MIP_CS. [Graphical view]
PANTHER	PTHR19139. PTHR19139. 1 hit.
Pfam	PF00230. MIP. 1 hit. [Graphical view]
PRINTS	PR00783. MINTRINSICP.
SUPFAM	SSF81338. MIP. 1 hit.
TIGRFAMs	TIGR00861. MIP. 1 hit.
PROSITE	PS00221. MIP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B0VMJ8_ACIBS

Accession

Primary (citable) accession number: B0VMJ8

Entry history

Integrated into UniProtKB/TrEMBL:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	May 1, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)