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Protein

Aquaporin Z

Gene

aqpZ

Organism
Acinetobacter baumannii (strain SDF)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei19Involved in tetramerization or stability of the tetramerUniRule annotation1
Sitei42Selectivity filterUniRule annotation1
Sitei172Selectivity filterUniRule annotation1
Sitei181Selectivity filterUniRule annotation1
Sitei187Selectivity filterUniRule annotation1

GO - Molecular functioni

Keywordsi

Biological processTransportUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin ZUniRule annotation
Gene namesi
Name:aqpZUniRule annotationImported
Ordered Locus Names:ABSDF3343Imported
OrganismiAcinetobacter baumannii (strain SDF)Imported
Taxonomic identifieri509170 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
Proteomesi
  • UP000001741 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 53HelicalUniRule annotationAdd BLAST19
Transmembranei80 – 102HelicalUniRule annotationAdd BLAST23
Transmembranei127 – 150HelicalUniRule annotationAdd BLAST24
Transmembranei157 – 178HelicalUniRule annotationAdd BLAST22
Transmembranei204 – 224HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB0VMJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi62 – 64NPA 1UniRule annotation3
Motifi184 – 186NPA 2UniRule annotation3

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).UniRule annotation

Sequence similaritiesi

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]UniRule annotation

Keywords - Domaini

RepeatUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

HOGENOMiHOG000288286.
KOiK06188.
OMAiMPIIGGI.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
HAMAPiMF_01146. Aquaporin_Z. 1 hit.
InterProiView protein in InterPro
IPR023271. Aquaporin-like.
IPR034294. Aquaporin_transptr.
IPR023743. Aquaporin_Z.
IPR000425. MIP.
IPR022357. MIP_CS.
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiView protein in Pfam
PF00230. MIP. 1 hit.
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiView protein in PROSITE
PS00221. MIP. 1 hit.

Sequencei

Sequence statusi: Complete.

B0VMJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKYFAEFLG TFWLVFGGCG SAVLAAAFPE LGIGFAGVAL AFGLTVLTGA
60 70 80 90 100
YALGHISGGH FNPAVSVGLW VGGRFDVKDL IPYIVAQVVG ATAAAFVLYI
110 120 130 140 150
IAQGQAGFSG VGGFAANGFG DLSPNKFGLG SAFIIEVVLT AFFLIIILGA
160 170 180 190 200
TDRRAPAGFA PIAIGLGLTL IHLISIPVTN TSVNPARSTG VAFFAETAAL
210 220
SQLWLFWVAP ILGAVIGAII YKVVAGDKD
Length:229
Mass (Da):23,443
Last modified:April 8, 2008 - v1
Checksum:iE6CB05D97950F795
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468230 Genomic DNA. Translation: CAP02612.1.

Genome annotation databases

EnsemblBacteriaiCAP02612; CAP02612; ABSDF3343.
KEGGiabm:ABSDF3343.
PATRICi20737366. VBIAciBau88365_3158.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468230 Genomic DNA. Translation: CAP02612.1.

3D structure databases

ProteinModelPortaliB0VMJ8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAP02612; CAP02612; ABSDF3343.
KEGGiabm:ABSDF3343.
PATRICi20737366. VBIAciBau88365_3158.

Phylogenomic databases

HOGENOMiHOG000288286.
KOiK06188.
OMAiMPIIGGI.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
HAMAPiMF_01146. Aquaporin_Z. 1 hit.
InterProiView protein in InterPro
IPR023271. Aquaporin-like.
IPR034294. Aquaporin_transptr.
IPR023743. Aquaporin_Z.
IPR000425. MIP.
IPR022357. MIP_CS.
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiView protein in Pfam
PF00230. MIP. 1 hit.
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiView protein in PROSITE
PS00221. MIP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB0VMJ8_ACIBS
AccessioniPrimary (citable) accession number: B0VMJ8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: March 15, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.