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B0VLU2 (IF2_ACIBS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:ABSDF3180
OrganismAcinetobacter baumannii (strain SDF) [Complete proteome] [HAMAP]
Taxonomic identifier509170 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length899 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00100.

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 899899Translation initiation factor IF-2 HAMAP-Rule MF_00100
PRO_1000093750

Regions

Nucleotide binding408 – 4158GTP By similarity
Nucleotide binding454 – 4585GTP By similarity
Nucleotide binding508 – 5114GTP By similarity
Region402 – 550149G-domain HAMAP-Rule MF_00100

Sequences

Sequence LengthMass (Da)Tools
B0VLU2 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 832E70ED099C9BFD

FASTA89997,297
        10         20         30         40         50         60 
MTDKSIKELA LSVGRPVEKL LEQAREAGLP QRTADDIITT EQQDTLVNYL KKVHGQESGN 

        70         80         90        100        110        120 
TGKIALKRKT TSTAKVASTS GKAKTINVEV RKKQVFAKPN PEQIAAEAKA RAEAEAKARA 

       130        140        150        160        170        180 
EQQAREAAEQ KARLQTEQKA KATLDAMRAA HQQDSAAQSA PKAAVVVEKR GGGTVKPAPK 

       190        200        210        220        230        240 
PAETLEQKKA REAQTAQLKA TEEAARRKAA EEAQQRTLEQ MRKMASKYSN DDATATIRVI 

       250        260        270        280        290        300 
DDSPLASGLV GQAYEDSFNQ EDREIKRGGA TTNPRAGKKG GRRGQEEQSF VNHNKRGLKS 

       310        320        330        340        350        360 
SQANKHGFEK PVKKQVYDVE IGSSIVVADL AQKMAIKVRE VIKTLMKMGE LVNQNQTIDQ 

       370        380        390        400        410        420 
DTAALVVEEM GHNPVLVSDT QAEDNLLEAA EEARGEQTTR PPVVTIMGHV DHGKTSLLDR 

       430        440        450        460        470        480 
IRRSKVAAGE AGGITQHIGA YHVETDKGII TFLDTPGHAA FTSMRARGAK ATDIVVLVVA 

       490        500        510        520        530        540 
ADDGVMPQTA EAIDHARAAG TPIIVAINKM DKESADPDRV LNELTTKEIV PEEWGGDVPV 

       550        560        570        580        590        600 
AKVSAHTGQG IDELLDLILI QSELMELKAS AEGAAQGVVI EARVDKGRGA VTSILVQNGT 

       610        620        630        640        650        660 
LNIGDLVLAG SSYGRVRAMS DENGKPIKSA GPSIPVEILG LPEAPMAGDE VLVVNDEKKA 

       670        680        690        700        710        720 
REVADARADR EREKRIERQS AMRLENIMAS MGKKDVPTVN VVLRTDVRGT LEALNAALHE 

       730        740        750        760        770        780 
LSTDEVKVRV ISSGVGAITE SDVILAESSE AVLLGFNVRA DTAARQKSDQ DGIDIRYYSI 

       790        800        810        820        830        840 
IYELIDDVKD AMSGKLAPEH RETILGVAQV REVFRSSKFG AAAGCMVMEG VIHRNKPIRV 

       850        860        870        880        890 
LRDDVVIFQG ELESLRRYKD VVDEVRAGME CGLAVKGYND IKPLDKIEVY DVQIVKRSL 

« Hide

References

[1]"Comparative analysis of Acinetobacters: three genomes for three lifestyles."
Vallenet D., Nordmann P., Barbe V., Poirel L., Mangenot S., Bataille E., Dossat C., Gas S., Kreimeyer A., Lenoble P., Oztas S., Poulain J., Segurens B., Robert C., Abergel C., Claverie J.-M., Raoult D., Medigue C., Weissenbach J., Cruveiller S.
PLoS ONE 3:E1805-E1805(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SDF.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU468230 Genomic DNA. Translation: CAP02458.1.
RefSeqYP_001708289.1. NC_010400.1.

3D structure databases

ProteinModelPortalB0VLU2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING509170.ABSDF3180.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAP02458; CAP02458; ABSDF3180.
GeneID5987248.
KEGGabm:ABSDF3180.
PATRIC20737053. VBIAciBau88365_3011.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000076907.
KOK02519.
OMANFECGLS.
OrthoDBEOG67HJSV.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00100_B. IF_2_B.
InterProIPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS01176. IF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2_ACIBS
AccessionPrimary (citable) accession number: B0VLU2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries