Reviewed, UniProtKB/Swiss-Prot B0VLH2 (PYRB_ACIBS)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	ABSDF1477

Organism

Acinetobacter baumannii (strain SDF) [Complete proteome] [HAMAP]

Taxonomic identifier

509170 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_1000088729

Sequences

	Sequence		Length	Mass (Da)
	B0VLH2-1 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: CAEA3A07E3E30DDB	FASTA	338	37,194
	10 20 30 40 50 60 MHIAALHQPS QVQLNQDGNL KHFLTIEGLS KENLTKILDT AQSFLDDNNN LINRPLLEGR 70 80 90 100 110 120 TVMNLFFENS TRTRTTFEAA AKRLSANVLN IDIARSSTSK GETLRDTLWN LEAMAADIFV 130 140 150 160 170 180 VRHSSSGAAH FIAKDVCPKV AIINAGDGRH AHPTQAMLDM LTIRREMKKP FEDLSVAIIG 190 200 210 220 230 240 DIKHSRVARS DVAALQTLGC KDIRVIAPNT LLPVGFSEYG DHVRLFNNMD EGITGCDVII 250 260 270 280 290 300 ALRIQNERID SPALSSQSEF YRMYGLNKER LSLAKPDCIV MHPGPMNRGV EIDSSIADGE 310 320 330 QSVILKQVTN GIAVRMAVLA LSMQGQLQEQ GLIDAIAL

References

[1]

"Comparative analysis of Acinetobacters: three genomes for three lifestyles." Vallenet D., Nordmann P., Barbe V., Poirel L., Mangenot S., Bataille E., Dossat C., Gas S., Kreimeyer A., Lenoble P., Oztas S., Poulain J., Segurens B., Robert C., Abergel C., Claverie J.-M., Raoult D., Medigue C., Weissenbach J., Cruveiller S. PLoS ONE 3:E1805-E1805(2008) [PubMed: 18350144] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU468230 Genomic DNA. Translation: CAP00821.1.
RefSeq	YP_001706904.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5984921.
GenomeReviews	Gene locus ABSDF1477 in contig CU468230_GR.
KEGG	abm:ABSDF1477.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	RTVVNLF.
Family and domain databases
HAMAP	MF_00001. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_ACIBS

Accession

Primary (citable) accession number: B0VLH2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 8, 2008
Last modified:	November 3, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)