B0VL72 (MSRA_ACIBS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA
Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase

Gene names

Name:	msrA
Ordered Locus Names:	ABSDF3055

Organism

Acinetobacter baumannii (strain SDF) [Complete proteome] [HAMAP]

Taxonomic identifier

509170 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length	174 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 174	174	Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401		PRO_1000145391
Sites
	Active site	10	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0VL72 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 54B5C18BFE9C4295	FASTA	174	19,962
	10 20 30 40 50 60 MQQALFGGGC FWCVEAVFLQ IRGVEKVTSG YAGGHTTHPT YEQVCQGDTQ HAEVVLIDFD 70 80 90 100 110 120 EQQVTYSQLL DVFFATHDPT TLNRQGNDIG TQYRSVIYYF NEEQKQAAEH TIQTLKDDDL 130 140 150 160 170 DIVTELSPAP TFYPAEDYHQ NYYEKNPSQG YCNFAIPPKL LKLYSKFQHL MKDQ

References

[1]

"Comparative analysis of Acinetobacters: three genomes for three lifestyles." Vallenet D., Nordmann P., Barbe V., Poirel L., Mangenot S., Bataille E., Dossat C., Gas S., Kreimeyer A., Lenoble P., Oztas S., Poulain J., Segurens B., Robert C., Abergel C., Claverie J.-M., Raoult D., Medigue C., Weissenbach J., Cruveiller S. PLoS ONE 3:E1805-E1805(2008) [PubMed: 18350144] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SDF.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU468230 Genomic DNA. Translation: CAP02340.1.
RefSeq	YP_001708184.1. NC_010400.1.
3D structure databases
ProteinModelPortal	B0VL72.
ModBase	Search...
Protein-protein interaction databases
STRING	B0VL72.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5986021.
GenomeReviews	Gene locus ABSDF3055 in contig CU468230_GR.
KEGG	abm:ABSDF3055.
PATRIC	20736811. VBIAciBau88365_2892.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG748152.
OMA	QETSFEQ.
ProtClustDB	CLSK2307291.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_ACIBS

Accession

Primary (citable) accession number: B0VL72

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	April 8, 2008
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program