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B0VKP9

- SYL_ACIBS

UniProt

B0VKP9 - SYL_ACIBS

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Protein

Leucine--tRNA ligase

Gene
leuS, ABSDF2980
Organism
Acinetobacter baumannii (strain SDF)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei639 – 6391ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:ABSDF2980
OrganismiAcinetobacter baumannii (strain SDF)
Taxonomic identifieri509170 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
ProteomesiUP000001741: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 874874Leucine--tRNA ligaseUniRule annotationPRO_1000091280Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi509170.ABSDF2980.

Structurei

3D structure databases

ProteinModelPortaliB0VKP9.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi47 – 5711"HIGH" regionUniRule annotationAdd
BLAST
Motifi636 – 6405"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0VKP9-1 [UniParc]FASTAAdd to Basket

« Hide

MTISHIDPEY QANTIEPSVQ QDWENRKVFK VADTVEGKHR YILSMFPYPS    50
GKLHMGHVRN YTIGDVISRF YRLKGETVLQ PMGWDAFGLP AENAAIAHKV 100
APAKWTFENI AYMRDQLKKL GLSVDWDREF ATCTPEYYHW EQWLFVQLYK 150
KGLIYRKLST VNWDPVDQTV LANEQVENGR GWRSGALVEK RDIPMYYFRI 200
TDYAQELLDD LDTLQDGWPQ QVLTMQRNWI GRSTGMEITF PSANTEIYAD 250
GLTVYTTRAD TLMGVTYVAV AAEHPLALKA AENNPELAAF IEECRIGSVA 300
EADLATAEKK GMATGLFVKH PVTGEELPVW IANYVLMSYG SGAVMAVPAH 350
DERDFEFANK FNLPIKQVID AKGADDADYS ATEWQEWYGS KEGKLVNSGE 400
FDGLEFQAAF DAFLAKLEPQ GLANSKVQFR LRDWGVSRQR YWGCPIPMIN 450
CDTCGQVTVP EDQLPVVLPT DVVPDGSGNP LNKMPEFYET KCPCCGGDAR 500
RETDTLDTFV ESSWYYARYA SPDFTGGIVK PEAAKNWLPV NQYIGGVEHA 550
ILHLLYARFF HKLMHDEGVV QGNEPFTNLL TQGMVLADTF YREAENGKKT 600
WFNPANIELE RDEKGRIISA KYSGDGQEVI IGGQEKMSKS KNNGIDPQAI 650
IDQYGADTAR VFMMFAAPPD QSLEWSDAGV EGANRFLKRV WRLVASFLEK 700
GNSATAIDKA NLSKDAQDLR RKTHETIQKV SDDIERRHAF NTAIAALMEL 750
LNASNKFEAK DDNDVAVERE AITTLLTLLA PFAPHLSQTL LAQFGTDLTE 800
ATFPEVDASA LTRNTQTIVV QVNGKLRGKL EVSVDISKDE LLAQAKALPE 850
VQQFLTGPTK KEIVVPNKLV NLVV 874
Length:874
Mass (Da):98,024
Last modified:April 8, 2008 - v1
Checksum:i6AEEF802D3C70895
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU468230 Genomic DNA. Translation: CAP02268.1.
RefSeqiYP_001708122.1. NC_010400.1.

Genome annotation databases

EnsemblBacteriaiCAP02268; CAP02268; ABSDF2980.
GeneIDi5985982.
KEGGiabm:ABSDF2980.
PATRICi20736667. VBIAciBau88365_2820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU468230 Genomic DNA. Translation: CAP02268.1 .
RefSeqi YP_001708122.1. NC_010400.1.

3D structure databases

ProteinModelPortali B0VKP9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 509170.ABSDF2980.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP02268 ; CAP02268 ; ABSDF2980 .
GeneIDi 5985982.
KEGGi abm:ABSDF2980.
PATRICi 20736667. VBIAciBau88365_2820.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SDF.

Entry informationi

Entry nameiSYL_ACIBS
AccessioniPrimary (citable) accession number: B0VKP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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