Reviewed, UniProtKB/Swiss-Prot B0VKC7 (GCP_ACIBS)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	ABSDF1284

Organism

Acinetobacter baumannii (strain SDF) [Complete proteome] [HAMAP]

Taxonomic identifier

509170 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc By similarity.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_1000145941
Sites
	Metal binding	111	1	Zinc Potential
	Metal binding	115	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	B0VKC7-1 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 0877B702A62CE297	FASTA	336	36,188
	10 20 30 40 50 60 MIVLGLETSC DETGLALYDS ELGLRGQVLY SQIKLHAEYG GVVPELASRD HVRKLIPLMN 70 80 90 100 110 120 QLLEQSGVKK QEIDAVAYTR GPGLMGALMT GALFGRTLAF SLNKPAIGVH HMEGHMLAPL 130 140 150 160 170 180 LSSQPPEFPF VALLVSGGHT QLMVVHGIGQ YELLGESIDD AAGEAFDKVA KMMNLPYPGG 190 200 210 220 230 240 PNIAKLALSG DPLAFEFPRP MLHQGLDFSF SGLKTAVSVQ LKKLNGENRD ADIAASFQEA 250 260 270 280 290 300 IVDTLVKKSV KALKQTGLKR LVIAGGVSAN LRLREQLETS LARIKAQVYY AEPALCTDNG 310 320 330 AMIAFAGYQR LKAGQHDGLA VTTTPRWPMT ELTIPE

References

[1]

"Comparative analysis of Acinetobacters: three genomes for three lifestyles." Vallenet D., Nordmann P., Barbe V., Poirel L., Mangenot S., Bataille E., Dossat C., Gas S., Kreimeyer A., Lenoble P., Oztas S., Poulain J., Segurens B., Robert C., Abergel C., Claverie J.-M., Raoult D., Medigue C., Weissenbach J., Cruveiller S. PLoS ONE 3:E1805-E1805(2008) [PubMed: 18350144] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU468230 Genomic DNA. Translation: CAP00630.1.
RefSeq	YP_001706753.1.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	5987350.
GenomeReviews	Gene locus ABSDF1284 in contig CU468230_GR.
KEGG	abm:ABSDF1284.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MEVIGQT.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_Osialgl. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
ProDom	PD002367. Peptidase_M22. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_ACIBS

Accession

Primary (citable) accession number: B0VKC7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	April 8, 2008
Last modified:	November 3, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)