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Protein

Succinate--CoA ligase [ADP-forming] subunit alpha

Gene

sucD

Organism
Acinetobacter baumannii (strain AYE)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.UniRule annotation

Catalytic activityi

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.UniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes succinate from succinyl-CoA (ligase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate--CoA ligase [ADP-forming] subunit beta (sucC), Succinate--CoA ligase [ADP-forming] subunit alpha (sucD)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinate from succinyl-CoA (ligase route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43Coenzyme AUniRule annotation1
Binding sitei161Substrate; shared with subunit betaUniRule annotation1
Active sitei249Tele-phosphohistidine intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processTricarboxylic acid cycleUniRule annotation
LigandNucleotide-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00223; UER00999.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate--CoA ligase [ADP-forming] subunit alphaUniRule annotation (EC:6.2.1.5UniRule annotation)
Alternative name(s):
Succinyl-CoA synthetase subunit alphaUniRule annotation
Short name:
SCS-alphaUniRule annotation
Gene namesi
Name:sucDUniRule annotationImported
Ordered Locus Names:ABAYE0784Imported
OrganismiAcinetobacter baumannii (strain AYE)Imported
Taxonomic identifieri509173 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
Proteomesi
  • UP000002446 Componenti: Chromosome

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB0VEF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 100CoA_bindingInterPro annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 20Coenzyme A bindingUniRule annotation4
Regioni96 – 98Coenzyme A bindingUniRule annotation3

Sequence similaritiesi

Belongs to the succinate/malate CoA ligase alpha subunit family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000239685.
KOiK01902.
OMAiIIFVPPA.

Family and domain databases

Gene3Di3.40.50.261. 1 hit.
HAMAPiMF_01988. Succ_CoA_alpha. 1 hit.
InterProiView protein in InterPro
IPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR033847. Citrt_syn/SCS-alpha_CS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR036291. NAD(P)-bd_dom_sf.
IPR016102. Succinyl-CoA_synth-like.
PfamiView protein in Pfam
PF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
PIRSFiPIRSF001553. SucCS_alpha. 1 hit.
SMARTiView protein in SMART
SM00881. CoA_binding. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF52210. SSF52210. 1 hit.
TIGRFAMsiTIGR01019. sucCoAalpha. 1 hit.
PROSITEiView protein in PROSITE
PS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B0VEF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLINKDTK VLVQGFTGKN GTFHSAQALD YGTKVVGGVT PGKGGTTHLD
60 70 80 90 100
LPVFNTMKEA VRETNADASV IYVPAPFVLD SIVEAVDSGV GLIVVITEGV
110 120 130 140 150
PTIDMLKAKR YLETNGNGTR LVGPNCPGVI TPGECKIGIM PGHIHQPGRI
160 170 180 190 200
GIISRSGTLT YEAVAQTTKL GLGQSTCIGI GGDPIPGMNQ IEALQLFQDD
210 220 230 240 250
PDTDAIIMIG EIGGTAEEEA AEFIKSNVTK PVVGYIAGVT APKGKRMGHA
260 270 280 290
GAIISGGQGT AEEKFAAFEK AGMAYTRSPA ELGSTMLQVL KEKGLA
Length:296
Mass (Da):30,693
Last modified:April 8, 2008 - v1
Checksum:iC058EDD2BA17CF92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU459141 Genomic DNA. Translation: CAM85740.1.
RefSeqiWP_000114637.1. NC_010410.1.

Genome annotation databases

EnsemblBacteriaiCAM85740; CAM85740; ABAYE0784.
GeneIDi31348991.
KEGGiaby:ABAYE0784.

Similar proteinsi

Entry informationi

Entry nameiB0VEF3_ACIBY
AccessioniPrimary (citable) accession number: B0VEF3
Secondary accession number(s): V5VAD7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: October 25, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported