Reviewed, UniProtKB/Swiss-Prot B0VEC9 (HEMH_ACIBY)

Names and origin

Protein names

Recommended name:
    Ferrochelatase
    EC=4.99.1.1
Alternative name(s):
    Protoheme ferro-lyase
    Heme synthetase

Gene names

Name:	hemH
Ordered Locus Names:	ABAYE3393

Organism

Acinetobacter baumannii (strain AYE) [Complete proteome] [HAMAP]

Taxonomic identifier

509173 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX By similarity.
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ferrochelatase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Ferrochelatase HAMAP MF_00323		PRO_1000116025
Sites
	Metal binding	202	1	Iron By similarity
	Metal binding	283	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0VEC9-1 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 60EBEE2A3FCD244E	FASTA	338	38,276
	10 20 30 40 50 60 MSFEQKPKVT VILANLGTPD EATVPAVRRF LKQFLSDPRV IEIPKFIWWI ILNLFVLPFR 70 80 90 100 110 120 PKRVAHAYAS VWSTDSPMRE IVFEQTQRVQ AYLERENKQF DLTVLPAMTY GNPGIDAVLE 130 140 150 160 170 180 KLATNPQEHV ILLPLFPQYS ATSTAPLYDA FAKWIPTQRN LPGLTIIKDY YQHPMFIQAL 190 200 210 220 230 240 AESVLAYQEQ HGKPEKLLMS FHGIPQPYAD KGDPYADRCR ITAKLVAEAL HLKDDEWAIS 250 260 270 280 290 300 FQSRFGKQEW VKPYTDQLLQ DWAKQGVKSV QVLSPAFSAD CLETLEELAI QNAELFQQAG 310 320 330 GGSYAYIPAL NSDQAHIDLL AGLVQANLDA LTHTLAHR

References

[1]

"Comparative analysis of Acinetobacters: three genomes for three lifestyles." Vallenet D., Nordmann P., Barbe V., Poirel L., Mangenot S., Bataille E., Dossat C., Gas S., Kreimeyer A., Lenoble P., Oztas S., Poulain J., Segurens B., Robert C., Abergel C., Claverie J.-M., Raoult D., Medigue C., Weissenbach J., Cruveiller S. PLoS ONE 3:E1805-E1805(2008) [PubMed: 18350144] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU459141 Genomic DNA. Translation: CAM88188.1.
RefSeq	YP_001715157.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6002505.
GenomeReviews	Gene locus ABAYE3393 in contig CU459141_GR.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	TIEEIGM.
Family and domain databases
HAMAP	MF_00323. [Tree]
InterPro	IPR001015. Ferrochelatase. IPR019772. Ferrochelatase_AS. [Graphical view]
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
ProDom	PD002792. Ferrochelatase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00109. hemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMH_ACIBY

Accession

Primary (citable) accession number: B0VEC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 8, 2008
Last modified:	November 3, 2009
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)