Aminoglycoside 3'-phosphotransferase AphA1-IAB - Acinetobacter baumannii (strain AYE)

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B0VD92 (B0VD92_ACIBY) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 28. History...

Clusters with 100%, 90%, 50% identity |

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Names·Attributes·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

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Names·Attributes·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
Aminoglycoside 3'-phosphotransferase AphA1-IAB EMBL CAM88361.1
EC=2.7.1.95 EMBL CAM88361.1

Gene names

Ordered Locus Names:

ABAYE3578 EMBL CAM88361.1

Organism

Acinetobacter baumannii (strain AYE) [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex ›

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Molecular function	Transferase EMBL CAM88361.1
Technical term	3D-structure PDB 4EJ7 PDB 4FEU PDB 4FEV PDB 4FEW PDB 4FEX PDB 4GKH PDB 4GKI Complete proteome
Gene Ontology (GO)
Biological_process	response to antibiotic Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro kanamycin kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

B0VD92 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 3B8CE6C591219263
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271

30,930

        10         20         30         40         50         60 
MSHIQRETSC SRPRLNSNLD ADLYGYRWAR DNVGQSGATI YRLYGKPNAP ELFLKHGKGS 

        70         80         90        100        110        120 
VANDVTDEMV RLNWLTAFMP LPTIKHFIRT PDDAWLLTTA IPGKTAFQVL EEYPDSGENI 

       130        140        150        160        170        180 
VDALAVFLRR LHSIPVCNCP FNSDRVFRLA QAQSRMNNGL VDASDFDDER NGWPVEQVWK 

       190        200        210        220        230        240 
EMHKLLPFSP DSVVTHGDFS LDNLIFDEGK LIGCIDVGRV GIADRYQDLA ILWNCLGEFS 

       250        260        270 
PSLQKRLFQK YGIDNPDMNK LQFHLMLDEF F

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative analysis of Acinetobacters: three genomes for three lifestyles." Vallenet D., Nordmann P., Barbe V., Poirel L., Mangenot S., Bataille E., Dossat C., Gas S., Kreimeyer A., Lenoble P., Oztas S., Poulain J., Segurens B., Robert C., Abergel C., Claverie J.-M., Raoult D., Medigue C., Weissenbach J., Cruveiller S. PLoS ONE 3:e1805-e1805(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AYE EMBL CAM88361.1.
[2]	"Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, ATP-bound." Center for Structural Genomics of Infectious Diseases (CSGID) Stogios P.J., Minasov G., Tan K., Evdokimova E., Egorova O., Di Leo R., Shakya T., Wright G.D., Savchenko A., Anderson W.F. Submitted (APR-2012) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.29 ANGSTROMS).
[3]	"Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor anthrapyrazolone SP600125." Center for Structural Genomics of Infectious Diseases (CSGID) Stogios P.J., Evdokimova E., Wawrzak Z., Minasov G., Egorova O., Di Leo R., Shakya T., Spanogiannopoulos P., Wright G.D., Savchenko A., Anderson W.F. Submitted (MAY-2012) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.37 ANGSTROMS).
[4]	"Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP1." Center for Structural Genomics of Infectious Diseases (CSGID) Stogios P.J., Evdokimova E., Wawrzak Z., Minasov G., Egorova O., Di Leo R., Shakya T., Spanogiannopoulos P., Wright G.D., Savchenko A., Anderson W.F. Submitted (MAY-2012) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.89 ANGSTROMS).
[5]	"Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP2." Center for Structural Genomics of Infectious Diseases (CSGID) Stogios P.J., Evdokimova E., Wawrzak Z., Minasov G., Egorova O., Di Leo R., Shakya T., Spanogiannopoulos P., Wright G.D., Savchenko A., Anderson W.F. Submitted (MAY-2012) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.98 ANGSTROMS).
[6]	"Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor tyrphostin AG1478." Center for Structural Genomics of Infectious Diseases (CSGID) Stogios P.J., Evdokimova E., Wawrzak Z., Minasov G., Egorova O., Di Leo R., Shakya T., Spanogiannopoulos P., Wright G.D., Savchenko A., Anderson W.F. Submitted (MAY-2012) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.71 ANGSTROMS).
[7]	"Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor 1-NA-PP1." Center for Structural Genomics of Infectious Diseases (CSGID) Stogios P.J., Evdokimova E., Wawrzak Z., Minasov G., Egorova O., Di Leo R., Shakya T., Spanogiannopoulos P., Todorovic N., Capretta A., Wright G.D., Savchenko A., Anderson W.F. Submitted (AUG-2012) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.86 ANGSTROMS).
[8]	"Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor 1-NM-PP1." Center for Structural Genomics of Infectious Diseases (CSGID) Stogios P.J., Evdokimova E., Wawrzak Z., Minasov G., Egorova O., Di Leo R., Shakya T., Spanogiannopoulos P., Todorovic N., Capretta A., Wright G.D., Savchenko A., Anderson W.F. Submitted (AUG-2012) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

CU459141 Genomic DNA. Translation: CAM88361.1.

RefSeq

YP_001715327.1. NC_010410.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4EJ7	X-ray	2.29	A/B/C	1-271	[»]
4FEU	X-ray	2.37	A/B/C/D/E/F	1-271	[»]
4FEV	X-ray	1.89	A/B/C/D/E/F	1-271	[»]
4FEW	X-ray	1.98	A/B/C/D/E/F	1-271	[»]
4FEX	X-ray	2.71	A/B/C/D/E	1-271	[»]
4GKH	X-ray	1.86	A/B/C/D/E/F/G/H/I/J/K/L	1-271	[»]
4GKI	X-ray	1.88	A/B/C/D/E/F/G/H/I/J/K/L	1-271	[»]

ProteinModelPortal

ModBase

Protein-protein interaction databases

STRING

509173.ABAYE3578.

Protocols and materials databases

StructuralBiologyKnowledgebase

Genome annotation databases

EnsemblBacteria

CAM88361; CAM88361; ABAYE3578.

GeneID

KEGG

PATRIC

20730280. VBIAciBau69881_3427.

Organism-specific databases

CMR

Phylogenomic databases

eggNOG

HOGENOM

KO

OMA

ProtClustDB

Enzyme and pathway databases

BioCyc

ABAU509173:GJXF-3457-MONOMER.

Family and domain databases

InterPro

IPR002575. Aminoglycoside_PTrfase.
IPR024165. Kan/Strep_kinase.
IPR011009. Kinase-like_dom.
[Graphical view]

PANTHER

PTHR21310. PTHR21310. 1 hit.

Pfam

PF01636. APH. 1 hit.
[Graphical view]

PIRSF

PIRSF000706. Kanamycin_kin. 1 hit.

SUPFAM

SSF56112. Kinase_like. 1 hit.

ProtoNet

Other

EvolutionaryTrace

Entry information

Entry name

B0VD92_ACIBY

Accession

Primary (citable) accession number: B0VD92

Entry history

Integrated into UniProtKB/TrEMBL:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	May 1, 2013
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

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Names·Attributes·Ontologies·Sequences·References·Cross-refs·Entry info