Reviewed, UniProtKB/Swiss-Prot B0VAL3 (PYRB_ACIBY)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	ABAYE2578

Organism

Acinetobacter baumannii (strain AYE) [Complete proteome] [HAMAP]

Taxonomic identifier

509173 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_1000088731

Sequences

	Sequence		Length	Mass (Da)
	B0VAL3-1 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: FE0596C42708E4E4	FASTA	338	37,168
	10 20 30 40 50 60 MHIAALHQPS QVQLNQDGNL KHFLTIEGLS KENLTKILDT AQSFLDDNNN LINRPLLEGR 70 80 90 100 110 120 TVMNLFFENS TRTRTTFEAA AKRLSANVLN IDIARSSTSK GETLRDTLWN LEAMAADIFV 130 140 150 160 170 180 VRHSSSGAAH FIAKDVCPKV AIINAGDGRH AHPTQAMLDM LTIRRETKKS FEDLSVAIIG 190 200 210 220 230 240 DIKHSRVARS DVAALQTLGC KDIRVIAPNT LLPVGFSEYG DHVRLFNNMD EGITGCDVII 250 260 270 280 290 300 ALRIQNERID SPALSSQSEF YRMYGLNKER LSLAKPDCIV MHPGPMNRGV EIDSSIADGE 310 320 330 QSVILKQVTN GIAVRMAVLA LSMQGQLQEQ GLIEAIAL

References

[1]

"Comparative analysis of Acinetobacters: three genomes for three lifestyles." Vallenet D., Nordmann P., Barbe V., Poirel L., Mangenot S., Bataille E., Dossat C., Gas S., Kreimeyer A., Lenoble P., Oztas S., Poulain J., Segurens B., Robert C., Abergel C., Claverie J.-M., Raoult D., Medigue C., Weissenbach J., Cruveiller S. PLoS ONE 3:E1805-E1805(2008) [PubMed: 18350144] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU459141 Genomic DNA. Translation: CAM87416.1.
RefSeq	YP_001714393.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6003751.
GenomeReviews	Gene locus ABAYE2578 in contig CU459141_GR.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	RTVVNLF.
Family and domain databases
HAMAP	MF_00001. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_ACIBY

Accession

Primary (citable) accession number: B0VAL3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 8, 2008
Last modified:	November 3, 2009
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)