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B0V945

- BETA_ACIBY

UniProt

B0V945 - BETA_ACIBY

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Protein
Oxygen-dependent choline dehydrogenase
Gene
betA, ABAYE2868
Organism
Acinetobacter baumannii (strain AYE)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei477 – 4771 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 3630FAD By similarity
Add
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciABAU509173:GJXF-2763-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:ABAYE2868
OrganismiAcinetobacter baumannii (strain AYE)
Taxonomic identifieri509173 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
ProteomesiUP000002446: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 552552Oxygen-dependent choline dehydrogenaseUniRule annotation
PRO_1000133319Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi509173.ABAYE2868.

Structurei

3D structure databases

ProteinModelPortaliB0V945.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0V945-1 [UniParc]FASTAAdd to Basket

« Hide

MNIKEYDYII IGAGSAGNVL AARLTEDKDT TVLLLEAGGP DYRLDFRTQM    50
PAALAYPLQG RRYNWAYLTD PEPHMNNRRM ECGRGKGLGG SSLINGMCYI 100
RGNAMDLEQW ATHKGLENWT YADCLPYYKK AETRDIGGND YHGDSGPVSV 150
ATPKNGNNVL FHAMVEAGVQ AGYPRTDDLN GYQQEGFGPM DRTVTPKGRR 200
SSTARGYLDM AKGRPNLTIL THATTNKILF NQKQAIGVEY IIGADQNNLQ 250
RALVKREVLL CAGAIASPQI LQRSGVGQST FLKSMDIDVV HDLPGVGENL 300
QDHLEMYLQY KCKQPVSLYP ALKWYNQPAI GAEWLFNGTG IGASNQFEAG 350
GFIRSSDEFK WPNIQYHFLP VAINYNGSNA VKEHGFQAHV GSMRSPSRGR 400
IKLKSKDPFA HPSILFNYMS TEQDWREFRD AIRITREIMH QPALDPYRGD 450
EISPGKHLQT DAELDDFVRN HAETAYHPSC SCKMGEDEMA VVDGQGRVHG 500
MNGLRVVDAS IMPLIITGNL NATTIMIAEK IADQIRGREA LPRSTAPFYV 550
AS 552
Length:552
Mass (Da):61,302
Last modified:April 8, 2008 - v1
Checksum:iB1B3FF7E0172F7FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU459141 Genomic DNA. Translation: CAM87695.1.
RefSeqiYP_001714670.1. NC_010410.1.

Genome annotation databases

EnsemblBacteriaiCAM87695; CAM87695; ABAYE2868.
GeneIDi6003008.
KEGGiaby:ABAYE2868.
PATRICi20728905. VBIAciBau69881_2765.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU459141 Genomic DNA. Translation: CAM87695.1 .
RefSeqi YP_001714670.1. NC_010410.1.

3D structure databases

ProteinModelPortali B0V945.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 509173.ABAYE2868.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM87695 ; CAM87695 ; ABAYE2868 .
GeneIDi 6003008.
KEGGi aby:ABAYE2868.
PATRICi 20728905. VBIAciBau69881_2765.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci ABAU509173:GJXF-2763-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AYE.

Entry informationi

Entry nameiBETA_ACIBY
AccessioniPrimary (citable) accession number: B0V945
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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