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Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Acinetobacter baumannii (strain AYE)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei50 – 501Substrate; via amide nitrogenUniRule annotation
Binding sitei126 – 1261ATPUniRule annotation
Binding sitei171 – 1711ATPUniRule annotation
Binding sitei200 – 2001Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciABAU509173:GJXF-1431-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
Short name:
TH kinaseUniRule annotation
Short name:
Thz kinaseUniRule annotation
Gene namesi
Name:thiMUniRule annotation
Ordered Locus Names:ABAYE1466
OrganismiAcinetobacter baumannii (strain AYE)
Taxonomic identifieri509173 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
ProteomesiUP000002446 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275Hydroxyethylthiazole kinasePRO_0000383814Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi509173.ABAYE1466.

Structurei

3D structure databases

ProteinModelPortaliB0V782.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiSPVMAHA.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.

Sequencei

Sequence statusi: Complete.

B0V782-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTSNLIEQ VIEAWQNMQA KTPLVQCITN SVAANYTANV LLASGASPAM
60 70 80 90 100
IDNPYEAESF TKISSALSIN LGTPTSEQMQ AMQISAKTAQ LNNVPWVLDP
110 120 130 140 150
VGYGPILAWR SQMTDELLQF KPSVIRGNAS EISTLAGNQV QSKGVDSTLS
160 170 180 190 200
SDQAYQQAFS LLTHASCIAI SGESDYILSN EVDAVIQVNG GSPLQPKITA
210 220 230 240 250
TGCALGALIA AYSAVTTPTI AALSAHIHFA IAGKLAANQA QTMGSFSSIF
260 270
MDYIHMLDAN LIEQYADVKL LNKQA
Length:275
Mass (Da):29,148
Last modified:April 8, 2008 - v1
Checksum:i2036927450642BCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU459141 Genomic DNA. Translation: CAM86373.1.
RefSeqiWP_001089458.1. NC_010410.1.
YP_001713373.1. NC_010410.1.

Genome annotation databases

EnsemblBacteriaiCAM86373; CAM86373; ABAYE1466.
KEGGiaby:ABAYE1466.
PATRICi20726309. VBIAciBau69881_1473.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU459141 Genomic DNA. Translation: CAM86373.1.
RefSeqiWP_001089458.1. NC_010410.1.
YP_001713373.1. NC_010410.1.

3D structure databases

ProteinModelPortaliB0V782.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi509173.ABAYE1466.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAM86373; CAM86373; ABAYE1466.
KEGGiaby:ABAYE1466.
PATRICi20726309. VBIAciBau69881_1473.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiSPVMAHA.
OrthoDBiEOG628F8M.

Enzyme and pathway databases

UniPathwayiUPA00060; UER00139.
BioCyciABAU509173:GJXF-1431-MONOMER.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AYE.

Entry informationi

Entry nameiTHIM_ACIBY
AccessioniPrimary (citable) accession number: B0V782
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: April 8, 2008
Last modified: May 27, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.