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Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Acinetobacter baumannii (strain AYE)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Hydroxyethylthiazole kinase (thiM)
This subpathway is part of the pathway thiamine diphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole, the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei50Substrate; via amide nitrogenUniRule annotation1
Binding sitei126ATPUniRule annotation1
Binding sitei171ATPUniRule annotation1
Binding sitei200Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processThiamine biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00060; UER00139

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
Short name:
TH kinaseUniRule annotation
Short name:
Thz kinaseUniRule annotation
Gene namesi
Name:thiMUniRule annotation
Ordered Locus Names:ABAYE1466
OrganismiAcinetobacter baumannii (strain AYE)
Taxonomic identifieri509173 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
Proteomesi
  • UP000002446 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003838141 – 275Hydroxyethylthiazole kinaseAdd BLAST275

Structurei

3D structure databases

ProteinModelPortaliB0V782
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000114352
KOiK00878
OMAiKRPLVHN

Family and domain databases

CDDicd01170 THZ_kinase, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_00228 Thz_kinase, 1 hit
InterProiView protein in InterPro
IPR000417 Hyethyz_kinase
IPR029056 Ribokinase-like
PANTHERiPTHR44423 PTHR44423, 1 hit
PfamiView protein in Pfam
PF02110 HK, 1 hit
PIRSFiPIRSF000513 Thz_kinase, 1 hit
PRINTSiPR01099 HYETHTZKNASE
SUPFAMiSSF53613 SSF53613, 1 hit

Sequencei

Sequence statusi: Complete.

B0V782-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTSNLIEQ VIEAWQNMQA KTPLVQCITN SVAANYTANV LLASGASPAM
60 70 80 90 100
IDNPYEAESF TKISSALSIN LGTPTSEQMQ AMQISAKTAQ LNNVPWVLDP
110 120 130 140 150
VGYGPILAWR SQMTDELLQF KPSVIRGNAS EISTLAGNQV QSKGVDSTLS
160 170 180 190 200
SDQAYQQAFS LLTHASCIAI SGESDYILSN EVDAVIQVNG GSPLQPKITA
210 220 230 240 250
TGCALGALIA AYSAVTTPTI AALSAHIHFA IAGKLAANQA QTMGSFSSIF
260 270
MDYIHMLDAN LIEQYADVKL LNKQA
Length:275
Mass (Da):29,148
Last modified:April 8, 2008 - v1
Checksum:i2036927450642BCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU459141 Genomic DNA Translation: CAM86373.1
RefSeqiWP_001089458.1, NC_010410.1

Genome annotation databases

EnsemblBacteriaiCAM86373; CAM86373; ABAYE1466
KEGGiaby:ABAYE1466

Similar proteinsi

Entry informationi

Entry nameiTHIM_ACIBY
AccessioniPrimary (citable) accession number: B0V782
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: April 8, 2008
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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