Reviewed, UniProtKB/Swiss-Prot B0V710 (DXS_ACIBY)

Names and origin

Protein names

Recommended name:
    1-deoxy-D-xylulose-5-phosphate synthase
    EC=2.2.1.7
Alternative name(s):
    1-deoxyxylulose-5-phosphate synthase
      Short name=DXP synthase
      Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	ABAYE0381

Organism

Acinetobacter baumannii (strain AYE) [Complete proteome] [HAMAP]

Taxonomic identifier

509173 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	637 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity.
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP thiamin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 637	637	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_1000115714

Sequences

	Sequence		Length	Mass (Da)
	B0V710-1 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: D59CE8F7D347AC8D	FASTA	637	69,835
	10 20 30 40 50 60 MPHMLYTEIP TQRPVTPLLD AIDHPQQLRQ LEHSQLLQVA DELRQYILYA AGQSGGHFGA 70 80 90 100 110 120 NLGVVELTVA LHYCFNTPND RLVWDVGHQA YPHKILTGRR EQITTIRAKN GLAAFPAREE 130 140 150 160 170 180 SVFDTFGVGH SSTAISAGLG MSLARRYQKD PCEVVCIVGD GAMTAGMAFE AMNDAVAHDA 190 200 210 220 230 240 DLIVVLNDND MSISCSTGGF AKHLAAIWEK GHLVNVNEHG EAYIQPHPKW TYNSRLHQSA 250 260 270 280 290 300 TDAADNLFKA IGFDYFGPFD GHDVTQLVQV FNALKKRKGP RLVHVYTKKG KGFAPAEADP 310 320 330 340 350 360 ITYHAIGKIN AASGGKTPPK YSDVFGEWLC DEAAQDERLL AITPAMCEGS GMVKFAKQFP 370 380 390 400 410 420 QRFFDVAIAE QHAVTLAAGM ACEGLKPVVA IYSTFLQRGY DQLIHDVALQ NLDVTFGIDR 430 440 450 460 470 480 AGLVGEDGPT HAGAYDYAYM RTVPNMVIMA PKDENECRQM LHTAYAYNGP AAVRYPRGAG 490 500 510 520 530 540 VGVEIQKEMT VLELGKAEIV AEIKANSDEQ ITVLAFGSRV MVALEAAEQF AQKHDVSVCI 550 560 570 580 590 600 VNMRFVKPLD EQMIRDLAEH THLFVTVEEH AIMGGAGSAV NEFMAQEQIV KPIINLGLPD 610 620 630 SFLHQATHNQ MLQDCGLDAK GILNSIERAW LKVNQVV

References

[1]

"Comparative analysis of Acinetobacters: three genomes for three lifestyles." Vallenet D., Nordmann P., Barbe V., Poirel L., Mangenot S., Bataille E., Dossat C., Gas S., Kreimeyer A., Lenoble P., Oztas S., Poulain J., Segurens B., Robert C., Abergel C., Claverie J.-M., Raoult D., Medigue C., Weissenbach J., Cruveiller S. PLoS ONE 3:E1805-E1805(2008) [PubMed: 18350144] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU459141 Genomic DNA. Translation: CAM85356.1.
RefSeq	YP_001712361.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6003781.
GenomeReviews	Gene locus ABAYE0381 in contig CU459141_GR.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	QRFPDRY.
Family and domain databases
HAMAP	MF_00315. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00204. dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. False negative. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_ACIBY

Accession

Primary (citable) accession number: B0V710

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 8, 2008
Last modified:	November 3, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)