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B0V6R7

- MDH_ACIBY

UniProt

B0V6R7 - MDH_ACIBY

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Protein
Malate dehydrogenase
Gene
mdh, ABAYE0465
Organism
Acinetobacter baumannii (strain AYE)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei94 – 941Substrate By similarity
Binding sitei100 – 1001Substrate By similarity
Binding sitei107 – 1071NAD By similarity
Binding sitei114 – 1141NAD By similarity
Binding sitei133 – 1331Substrate By similarity
Binding sitei164 – 1641Substrate By similarity
Active sitei189 – 1891Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 177NAD By similarity
Nucleotide bindingi131 – 1333NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciABAU509173:GJXF-464-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:ABAYE0465
OrganismiAcinetobacter baumannii (strain AYE)
Taxonomic identifieri509173 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
ProteomesiUP000002446: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Malate dehydrogenaseUniRule annotation
PRO_1000191606Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi509173.ABAYE0465.

Structurei

3D structure databases

ProteinModelPortaliB0V6R7.
SMRiB0V6R7. Positions 2-327.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000220953.
KOiK00024.
OMAiHHCKVNM.
OrthoDBiEOG6PP9Q2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

Sequencei

Sequence statusi: Complete.

B0V6R7-1 [UniParc]FASTAAdd to Basket

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MKQPVRVAVT GAAGQIGYSL LFRIASGEML GKDQPVILQL LEVPVEKAQQ    50
ALKGVMMELD DCAFPLLAGM IGTDDPKVAF KDADYALLVG SRPRGPGMER 100
ADLLKVNGEI FIGQGQALNE VASRDVKVLV VGNPANTNAY IAMKSAPDLP 150
AKNFTAMLRL DHNRALTQVA QKAGVAVADI EKLTVWGNHS PTMYADYRFA 200
TANGESLKDK INDPAWNKDV FLPTVGKRGA AIIEARGLSS AASAANAAID 250
HMRDWALGTN GKWVTMGVPS DGSYGIPEGV MFGFPVTTEN GEYKIVQGLE 300
IDEFSRERIN FTLNELEEER AAIADMVK 328
Length:328
Mass (Da):35,323
Last modified:April 8, 2008 - v1
Checksum:i4A3ABDD04F615F6E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU459141 Genomic DNA. Translation: CAM85438.1.
RefSeqiYP_001712443.1. NC_010410.1.

Genome annotation databases

EnsemblBacteriaiCAM85438; CAM85438; ABAYE0465.
GeneIDi6000566.
KEGGiaby:ABAYE0465.
PATRICi20724393. VBIAciBau69881_0546.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU459141 Genomic DNA. Translation: CAM85438.1 .
RefSeqi YP_001712443.1. NC_010410.1.

3D structure databases

ProteinModelPortali B0V6R7.
SMRi B0V6R7. Positions 2-327.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 509173.ABAYE0465.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM85438 ; CAM85438 ; ABAYE0465 .
GeneIDi 6000566.
KEGGi aby:ABAYE0465.
PATRICi 20724393. VBIAciBau69881_0546.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000220953.
KOi K00024.
OMAi HHCKVNM.
OrthoDBi EOG6PP9Q2.

Enzyme and pathway databases

BioCyci ABAU509173:GJXF-464-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01517. Malate_dehydrog_2.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AYE.

Entry informationi

Entry nameiMDH_ACIBY
AccessioniPrimary (citable) accession number: B0V6R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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