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B0V6G5 (OTC_ACIBY) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ornithine carbamoyltransferase
Short name=OTCase
EC=2.1.3.3
Gene names
Name:arcB
Ordered Locus Names:ABAYE1571
OrganismAcinetobacter baumannii (strain AYE) [Complete proteome] [HAMAP]
Taxonomic identifier509173 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109

Pathway

Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109

Subcellular location

Cytoplasm By similarity HAMAP MF_01109.

Sequence similarities

Belongs to the ATCase/OTCase family.

Ontologies

Keywords
   Biological processArginine metabolism
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentornithine carbamoyltransferase complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionamino acid binding

Inferred from electronic annotation. Source: InterPro

ornithine carbamoyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Ornithine carbamoyltransferase HAMAP MF_01109
PRO_1000137084

Regions

Region53 – 575Carbamoyl phosphate binding By similarity
Region258 – 2614Ornithine binding By similarity

Sites

Binding site1041Carbamoyl phosphate By similarity
Binding site1311Carbamoyl phosphate By similarity
Site281Important for structural integrity By similarity
Site1441Important for structural integrity By similarity

Sequences

Sequence LengthMass (Da)Tools
B0V6G5 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 4B1DFB7BE247CAEA

FASTA30634,556
        10         20         30         40         50         60 
MALRHFLTLR DLSTLELNRI LERASELKKM QQSNKVYQPF VGKVLGMIFE KSSTRTRISF 

        70         80         90        100        110        120 
EAGINQFGGS AIFLSPRDTQ LGRGEPIEDS ARVISSMLDI VMIRTFGHDI VERFASYSKV 

       130        140        150        160        170        180 
PVINGLTDDH HPCQLLADLQ TYIEHRGSIE GKTVAWIGDG NNMCNSYIEA AHMMGFKLKI 

       190        200        210        220        230        240 
ASPKGYEPKP EFLAEFGHCV ELFDNAEDAA VNADLIVTDV WASMGQEEEQ KLREKAFANF 

       250        260        270        280        290        300 
QVNEKLMGLA HPDCLFMHCL PAHRGEEISE TMLDHKNAVV WDEAENRLHA QKALMEFLLN 


ENLKKA

« Hide

References

[1]"Comparative analysis of Acinetobacters: three genomes for three lifestyles."
Vallenet D., Nordmann P., Barbe V., Poirel L., Mangenot S., Bataille E., Dossat C., Gas S., Kreimeyer A., Lenoble P., Oztas S., Poulain J., Segurens B., Robert C., Abergel C., Claverie J.-M., Raoult D., Medigue C., Weissenbach J., Cruveiller S.
PLoS ONE 3:E1805-E1805(2008) [PubMed: 18350144] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AYE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU459141 Genomic DNA. Translation: CAM86469.1.
RefSeqYP_001713469.1. NC_010410.1.

3D structure databases

ProteinModelPortalB0V6G5.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0V6G5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6001304.
GenomeReviewsGene locus ABAYE1571 in contig CU459141_GR.
PATRIC20726498. VBIAciBau69881_1567.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG579429.
OMAGVDCVVT.
ProtClustDBPRK00779.

Family and domain databases

HAMAPMF_01109. OTCase.
[Tree]
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view]
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMSSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMsTIGR00658. Orni_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOTC_ACIBY
AccessionPrimary (citable) accession number: B0V6G5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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