B0V5G8 (ILVC_ACIBY) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 29.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ketol-acid reductoisomerase EC=1.1.1.86 Alternative name(s): Acetohydroxy-acid isomeroreductase Alpha-keto-beta-hydroxylacil reductoisomerase | ||||
| Gene names |
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| Organism | Acinetobacter baumannii (strain AYE) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 509173 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex |
Protein attributes
| Sequence length | 338 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435 (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435 |
| Pathway | Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435 |
| Sequence similarities | Belongs to the ketol-acid reductoisomerase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Branched-chain amino acid biosynthesis |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | branched chain family amino acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | coenzyme binding Inferred from electronic annotation. Source: InterPro ketol-acid reductoisomerase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 338 | 338 | Ketol-acid reductoisomerase HAMAP MF_00435 | PRO_1000124245 | |||||
Sites | |||||||||
| Active site | 107 | 1 | Potential | ||||||
Sequences
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References
| [1] | "Comparative analysis of Acinetobacters: three genomes for three lifestyles." Vallenet D., Nordmann P., Barbe V., Poirel L., Mangenot S., Bataille E., Dossat C., Gas S., Kreimeyer A., Lenoble P., Oztas S., Poulain J., Segurens B., Robert C., Abergel C., Claverie J.-M., Raoult D., Medigue C., Weissenbach J., Cruveiller S. PLoS ONE 3:E1805-E1805(2008) [PubMed: 18350144] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AYE. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CU459141 Genomic DNA. Translation: CAM88042.1. |
| RefSeq | YP_001715014.1. NC_010410.1. |
3D structure databases | |
| ProteinModelPortal | B0V5G8. |
| SMR | B0V5G8. Positions 1-327. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | B0V5G8. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 6002418. |
| GenomeReviews | Gene locus ABAYE3238 in contig CU459141_GR. |
| PATRIC | 20729632. VBIAciBau69881_3113. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG286525. |
| OMA | MAYAKGI. |
| ProtClustDB | PRK05479. |
Family and domain databases | |
| HAMAP | MF_00435. IlvC. [Tree] |
| InterPro | IPR008927. 6-PGluconate_DH_C-like. IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013328. DH_multihelical. IPR013116. IlvN. [Graphical view] |
| Gene3D | G3DSA:1.10.1040.10. Opine_DH. 1 hit. |
| PANTHER | PTHR21371. AcH_isomrdctse. 1 hit. |
| Pfam | PF01450. IlvC. 1 hit. PF07991. IlvN. 1 hit. [Graphical view] |
| SUPFAM | SSF48179. 6DGDH_C_like. 1 hit. |
| TIGRFAMs | TIGR00465. IlvC. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | ILVC_ACIBY | ||||||||
| Accession | Primary (citable) accession number: B0V5G8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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