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Protein

Pyrroloquinoline-quinone synthase

Gene

pqqC

Organism
Acinetobacter baumannii (strain AYE)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.UniRule annotation

Catalytic activityi

6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O.UniRule annotation

Pathwayi: pyrroloquinoline quinone biosynthesis

This protein is involved in the pathway pyrroloquinoline quinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pyrroloquinoline quinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

PQQ biosynthesis

Enzyme and pathway databases

BioCyciABAU509173:GJXF-1823-MONOMER.
UniPathwayiUPA00539.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrroloquinoline-quinone synthaseUniRule annotation (EC:1.3.3.11UniRule annotation)
Alternative name(s):
Coenzyme PQQ synthesis protein CUniRule annotation
Pyrroloquinoline quinone biosynthesis protein CUniRule annotation
Gene namesi
Name:pqqCUniRule annotation
Ordered Locus Names:ABAYE1880
OrganismiAcinetobacter baumannii (strain AYE)
Taxonomic identifieri509173 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
Proteomesi
  • UP000002446 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Pyrroloquinoline-quinone synthasePRO_1000131175Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB0V496.
SMRiB0V496. Positions 6-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PqqC family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000217947.
KOiK06137.
OMAiSRLDTWP.
OrthoDBiEOG6JTC7S.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
HAMAPiMF_00654. PQQ_syn_PqqC.
InterProiIPR016084. Haem_Oase-like_multi-hlx.
IPR011845. PQQ_synth_PqqC.
IPR004305. Thiaminase-2/PQQC.
[Graphical view]
PfamiPF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMiSSF48613. SSF48613. 1 hit.
TIGRFAMsiTIGR02111. PQQ_syn_pqqC. 1 hit.

Sequencei

Sequence statusi: Complete.

B0V496-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQTPEALTT EQFKQAIIDK GQYYHIYHPF HVMMYEGKAT QQQIQAWVAN
60 70 80 90 100
RYYYQINIPL KDAAIMANCP DQRVRQEWIQ RMIDQDGEYP DGGGREAWLR
110 120 130 140 150
LAEAVGLSRE QVISEELVLP GVRFAVDAYV NFARRASWRE AASSSLTELF
160 170 180 190 200
APQIHQSRLE SWPQHYPWID DKGYEYFRSR LSQARRDVEH GLTITLDSFT
210 220 230 240 250
THEQQQRMLE ILQFKLDILW SILDALTLAY VHNEAPYHSV TQERVWHKGL

FK
Length:252
Mass (Da):29,665
Last modified:April 8, 2008 - v1
Checksum:i9D00A7DBC1CA0959
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU459141 Genomic DNA. Translation: CAM86762.1.
RefSeqiWP_000195110.1. NC_010410.1.

Genome annotation databases

EnsemblBacteriaiCAM86762; CAM86762; ABAYE1880.
KEGGiaby:ABAYE1880.
PATRICi20727062. VBIAciBau69881_1849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU459141 Genomic DNA. Translation: CAM86762.1.
RefSeqiWP_000195110.1. NC_010410.1.

3D structure databases

ProteinModelPortaliB0V496.
SMRiB0V496. Positions 6-247.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAM86762; CAM86762; ABAYE1880.
KEGGiaby:ABAYE1880.
PATRICi20727062. VBIAciBau69881_1849.

Phylogenomic databases

HOGENOMiHOG000217947.
KOiK06137.
OMAiSRLDTWP.
OrthoDBiEOG6JTC7S.

Enzyme and pathway databases

UniPathwayiUPA00539.
BioCyciABAU509173:GJXF-1823-MONOMER.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
HAMAPiMF_00654. PQQ_syn_PqqC.
InterProiIPR016084. Haem_Oase-like_multi-hlx.
IPR011845. PQQ_synth_PqqC.
IPR004305. Thiaminase-2/PQQC.
[Graphical view]
PfamiPF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMiSSF48613. SSF48613. 1 hit.
TIGRFAMsiTIGR02111. PQQ_syn_pqqC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AYE.

Entry informationi

Entry nameiPQQC_ACIBY
AccessioniPrimary (citable) accession number: B0V496
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: November 11, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.