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Protein

alpha-1,2-Mannosidase

Gene

man1a2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotation, Hydrolase

Enzyme and pathway databases

ReactomeiR-DRE-6811438 Intra-Golgi traffic
R-DRE-964827 Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2

Protein family/group databases

CAZyiGH47 Glycoside Hydrolase Family 47

Names & Taxonomyi

Protein namesi
Recommended name:
alpha-1,2-MannosidaseUniRule annotation (EC:3.2.1.-UniRule annotation)
Gene namesi
Name:man1a2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-070912-390 man1a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSDARG00000041728

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000092968

Structurei

3D structure databases

ProteinModelPortaliB0V2X9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili104 – 153Sequence analysisAdd BLAST50

Sequence similaritiesi

Belongs to the glycosyl hydrolase 47 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2431 Eukaryota
ENOG410XP04 LUCA
GeneTreeiENSGT00390000016529
HOGENOMiHOG000181988
HOVERGENiHBG052389
KOiK01230
OMAiQYGWGHN
OrthoDBiEOG091G04C8
PhylomeDBiB0V2X9
TreeFamiTF313420

Family and domain databases

Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR012341 6hp_glycosidase-like_sf
IPR001382 Glyco_hydro_47
IPR036026 Seven-hairpin_glycosidases
PfamiView protein in Pfam
PF01532 Glyco_hydro_47, 1 hit
PRINTSiPR00747 GLYHDRLASE47
SUPFAMiSSF48225 SSF48225, 1 hit

Sequencei

Sequence statusi: Complete.

B0V2X9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTPALLPLS GRRIPTLSPG ASSFPHHRAT LRLSEKFILL LILSAFITLC
60 70 80 90 100
FGAFFFLPDN SKHKRFDFGL EDVLIPHIET EKESRHGSRQ VIHGVGAHDE
110 120 130 140 150
HRHREEEESL RDKIRADHER ALQEAKEKLR KSKEELKAEI QTAKAKVSED
160 170 180 190 200
LKKKDGPKPL PPVPMPKLVG VNDGDPGDPD TKEKRDKIRE MMKHAWDSYR
210 220 230 240 250
QYGWGHNELK PLAKKGHSTN IFGNSQMGAT IVDALDTLYI MGLHDEFKDG
260 270 280 290 300
QEWIEQNLDF SVNAEVSVFE VNIRFIGGLL AAYYLSGQEV FKLKAVQLAE
310 320 330 340 350
KLLPAFNTPT GIPWAMVNLK SGVGRNWGWA SGGSSILAEF GTLHMEFVHL
360 370 380 390 400
TYLTGNPAYY QKVMHIRKLL AKMDRPNGLY PNYLNPRTGR WGQHHTSVGG
410 420 430 440 450
LGDSFYEYLL KAWLMSDKTD AEARKTYDDA IEAIERHLIR KSNGGLTFIG
460 470 480 490 500
EWKNGHLERK MGHLTCFAGG MFALGADGSP DDKAGHYLQL GAEIAHTCHE
510 520 530 540 550
SYDRTVLKLG PEAFKFDSGL EAVAVRQNEK YYILRPEVIE TYWYMWRFTH
560 570 580 590 600
DPKYRQWGWE AAQAIDKHCR VSGGFSGVKD VYSSNPTYDD VQQSFFLAET
610 620 630 640
LKYLYLLFSS DELLPLENWV FNTEAHPLPV LHLGNITLPG SESQR
Length:645
Mass (Da):73,155
Last modified:April 8, 2008 - v1
Checksum:i7F7ED6450AF6C2E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR391919 Genomic DNA No translation available.
CT573229 Genomic DNA No translation available.
RefSeqiNP_001243551.1, NM_001256622.1
XP_005167594.1, XM_005167537.3
UniGeneiDr.7784

Genome annotation databases

EnsembliENSDART00000144248; ENSDARP00000120629; ENSDARG00000041728
ENSDART00000178434; ENSDARP00000143611; ENSDARG00000041728
GeneIDi335538
KEGGidre:335538

Similar proteinsi

Entry informationi

Entry nameiB0V2X9_DANRE
AccessioniPrimary (citable) accession number: B0V2X9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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