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B0V2N1

- PTPRS_MOUSE

UniProt

B0V2N1 - PTPRS_MOUSE

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Protein

Receptor-type tyrosine-protein phosphatase S

Gene

Ptprs

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Interacts with LAR-interacting protein LIP.1.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei1197 – 11982CleavageBy similarity
Binding sitei1516 – 15161SubstrateBy similarity
Active sitei1548 – 15481Phosphocysteine intermediateBy similarity
Binding sitei1592 – 15921SubstrateBy similarity
Active sitei1839 – 18391Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cerebellum development Source: MGI
  3. cerebral cortex development Source: MGI
  4. corpus callosum development Source: MGI
  5. hippocampus development Source: MGI
  6. spinal cord development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_196606. ECM proteoglycans.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase S (EC:3.1.3.48)
Short name:
R-PTP-S
Alternative name(s):
PTPNU-3
Receptor-type tyrosine-protein phosphatase sigma
Short name:
R-PTP-sigma
Gene namesi
Name:Ptprs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:97815. Ptprs.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 12571228ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1258 – 127821HelicalSequence AnalysisAdd
BLAST
Topological domaini1279 – 1907629CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 19071878Receptor-type tyrosine-protein phosphatase SPRO_0000358321Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 107PROSITE-ProRule annotation
Disulfide bondi156 ↔ 207PROSITE-ProRule annotation
Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi253 ↔ 298PROSITE-ProRule annotation
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi720 – 7201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi916 – 9161N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiB0V2N1.
PaxDbiB0V2N1.
PRIDEiB0V2N1.

PTM databases

PhosphoSiteiB0V2N1.

Expressioni

Tissue specificityi

Isoform 1 and isoform 6 are predominantly expressed in the brain (cerebrum and cerebellum) and to a lesser extent in the heart and skeletal muscle. Also found in neuronal-derived cell lines.1 Publication

Developmental stagei

Expression is seen in embryos between 8 dpc and 16 dpc and a peak expression is seen at 14 dpc.1 Publication

Gene expression databases

BgeeiB0V2N1.
ExpressionAtlasiB0V2N1. baseline and differential.
GenevestigatoriB0V2N1.

Interactioni

Subunit structurei

Interacts with PPFIA1, PPFIA2 and PPFIA3.By similarity

Protein-protein interaction databases

IntActiB0V2N1. 3 interactions.
MINTiMINT-129725.

Structurei

Secondary structure

1
1907
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1337 – 135822Combined sources
Helixi1368 – 13714Combined sources
Turni1373 – 13753Combined sources
Helixi1376 – 13783Combined sources
Helixi1388 – 13903Combined sources
Beta strandi1391 – 13933Combined sources
Turni1401 – 14044Combined sources
Beta strandi1405 – 14139Combined sources
Beta strandi1416 – 14238Combined sources
Helixi1428 – 14303Combined sources
Helixi1431 – 144010Combined sources
Beta strandi1445 – 14484Combined sources
Beta strandi1452 – 14543Combined sources
Beta strandi1457 – 14593Combined sources
Beta strandi1466 – 14727Combined sources
Beta strandi1475 – 148410Combined sources
Beta strandi1486 – 149914Combined sources
Beta strandi1503 – 15119Combined sources
Beta strandi1516 – 15183Combined sources
Helixi1524 – 153512Combined sources
Beta strandi1544 – 155310Combined sources
Helixi1554 – 156815Combined sources
Beta strandi1571 – 15744Combined sources
Helixi1576 – 15849Combined sources
Helixi1594 – 160916Combined sources
Helixi1617 – 16193Combined sources
Helixi1620 – 16278Combined sources
Helixi1638 – 16447Combined sources
Turni1657 – 16593Combined sources
Turni1665 – 16673Combined sources
Beta strandi1671 – 16733Combined sources
Turni1677 – 16793Combined sources
Beta strandi1696 – 17005Combined sources
Beta strandi1703 – 17053Combined sources
Beta strandi1709 – 17124Combined sources
Turni1717 – 17193Combined sources
Helixi1720 – 172910Combined sources
Beta strandi1734 – 17374Combined sources
Beta strandi1744 – 17474Combined sources
Beta strandi1755 – 17573Combined sources
Beta strandi1759 – 17613Combined sources
Beta strandi1764 – 177310Combined sources
Beta strandi1775 – 178612Combined sources
Turni1787 – 17893Combined sources
Beta strandi1792 – 18009Combined sources
Beta strandi1805 – 18073Combined sources
Helixi1813 – 182816Combined sources
Beta strandi1835 – 18439Combined sources
Helixi1844 – 186118Combined sources
Helixi1867 – 18759Combined sources
Helixi1885 – 190016Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3SR9X-ray2.40A1326-1901[»]
ProteinModelPortaliB0V2N1.
SMRiB0V2N1. Positions 29-807, 813-902, 907-1004, 1326-1901.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 12391Ig-like C2-type 1Add
BLAST
Domaini135 – 22490Ig-like C2-type 2Add
BLAST
Domaini232 – 31483Ig-like C2-type 3Add
BLAST
Domaini321 – 41191Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini416 – 51095Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini514 – 60390Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini608 – 70598Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini710 – 809100Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini810 – 90697Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST
Domaini907 – 1008102Fibronectin type-III 7PROSITE-ProRule annotationAdd
BLAST
Domaini1011 – 109585Fibronectin type-III 8PROSITE-ProRule annotationAdd
BLAST
Domaini1352 – 1607256Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
BLAST
Domaini1639 – 1898260Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1548 – 15547Substrate bindingBy similarity

Sequence similaritiesi

Contains 8 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00760000118900.
HOVERGENiHBG053758.
InParanoidiB0V2N1.
KOiK06778.
OMAiGGTERCG.
OrthoDBiEOG7M98FB.
PhylomeDBiB0V2N1.
TreeFamiTF312900.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 6 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: B0V2N1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPTWSPSVV SVVGPVGLFL VLLARGCLAE EPPRFIREPK DQIGVSGGVA
60 70 80 90 100
SFVCQATGDP KPRVTWNKKG KKVNSQRFET IDFDESSGAV LRIQPLRTPR
110 120 130 140 150
DENVYECVAQ NSVGEITIHA KLTVLREDQL PPGFPNIDMG PQLKVVERTR
160 170 180 190 200
TATMLCAASG NPDPEITWFK DFLPVDPSAS NGRIKQLRSG ALQIESSEET
210 220 230 240 250
DQGKYECVAT NSAGVRYSSP ANLYVRVRRV APRFSILPMS HEIMPGGNVN
260 270 280 290 300
ITCVAVGSPM PYVKWMQGAE DLTPEDDMPV GRNVLELTDV KDSANYTCVA
310 320 330 340 350
MSSLGVIEAV AQITVKSLPK APGTPVVTEN TATSITVTWD SGNPDPVSYY
360 370 380 390 400
VIEYKSKSQD GPYQIKEDIT TTRYSIGGLS PNSEYEIWVS AVNSIGQGPP
410 420 430 440 450
SESVVTRTGE QAPASAPRNV QARMLSATTM IVQWEEPVEP NGLIRGYRVY
460 470 480 490 500
YTMEPEHPVG NWQKHNVDDS LLTTVGSLLE DETYTVRVLA FTSVGDGPLS
510 520 530 540 550
DPIQVKTQQG VPGQPMNLRA EAKSETSIGL SWSAPRQESV IKYELLFREG
560 570 580 590 600
DRGREVGRTF DPTTAFVVED LKPNTEYAFR LAARSPQGLG AFTAVVRQRT
610 620 630 640 650
LQAKPSAPPQ DVKCTSLRST AILVSWRPPP PETHNGALVG YSVRYRPLGS
660 670 680 690 700
EDPDPKEVNN IPPTTTQILL EALEKWTEYR VTAVAYTEVG PGPESSPVVV
710 720 730 740 750
RTDEDVPSAP PRKVEAEALN ATAIRVLWRS PTPGRQHGQI RGYQVHYVRM
760 770 780 790 800
EGAEARGPPR IKDIMLADAQ EMVITNLQPE TAYSITVAAY TMKGDGARSK
810 820 830 840 850
PKVVVTKGAV LGRPTLSVQQ TPEGSLLARW EPPADAAEDP VLGYRLQFGR
860 870 880 890 900
EDAAPATLEL AAWERRFAAP AHKGATYVFR LAARGRAGLG EEAAAALSIP
910 920 930 940 950
EDAPRGFPQI LGAAGNVSAG SVLLRWLPPV PAERNGAIIK YTVSVREAGA
960 970 980 990 1000
PGPATETELA AAAQPGAETA LTLRGLRPET AYELRVRAHT RRGPGPFSPP
1010 1020 1030 1040 1050
LRYRLARDPV SPKNFKVKMI MKTSVLLSWE FPDNYNSPTP YKIQYNGLTL
1060 1070 1080 1090 1100
DVDGRTTKKL ITHLKPHTFY NFVLTNRGSS LGGLQQTVTA RTAFNMLSGK
1110 1120 1130 1140 1150
PSVAPKPDND GFIVVYLPDG QSPVTVQNYF IVMVPLRKSR GGQFPVLLGS
1160 1170 1180 1190 1200
PEDMDLEELI QDISRLQRRS LRHSRQLEVP RPYIAARFSI LPAVFHPGNQ
1210 1220 1230 1240 1250
KQYGGFDNRG LEPGHRYVLF VLAVLQKNEP TFAASPFSDP FQLDNPDPQP
1260 1270 1280 1290 1300
IVDGEEGLIW VIGPVLAVVF IICIVIAILL YKNKPDSKRK DSEPRTKCLL
1310 1320 1330 1340 1350
NNADLAPHHP KDPVEMRRIN FQTPGMLSHP PIPITDMAEH MERLKANDSL
1360 1370 1380 1390 1400
KLSQEYESID PGQQFTWEHS NLEANKPKNR YANVIAYDHS RVILQPLEGI
1410 1420 1430 1440 1450
MGSDYINANY VDGYRRQNAY IATQGPLPET FGDFWRMVWE QRSATVVMMT
1460 1470 1480 1490 1500
RLEEKSRIKC DQYWPNRGTE TYGFIQVTLL DTMELATFCV RTFSLHKNGS
1510 1520 1530 1540 1550
SEKREVRHFQ FTAWPDHGVP EYPTPFLAFL RRVKTCNPPD AGPIVVHCSA
1560 1570 1580 1590 1600
GVGRTGCFIV IDAMLERIKT EKTVDVYGHV TLMRSQRNYM VQTEDQYGFI
1610 1620 1630 1640 1650
HEALLEAVGC GNTEVPARSL YTYIQKLAQV EPGEHVTGME LEFKRLASSK
1660 1670 1680 1690 1700
AHTSRFITAS LPCNKFKNRL VNILPYESSR VCLQPIRGVE GSDYINASFI
1710 1720 1730 1740 1750
DGYRQQKAYI ATQGPLAETT EDFWRALWEN NSTIVVMLTK LREMGREKCH
1760 1770 1780 1790 1800
QYWPAERSAR YQYFVVDPMA EYNMPQYILR EFKVTDARDG QSRTVRQFQF
1810 1820 1830 1840 1850
TDWPEQGAPK SGEGFIDFIG QVHKTKEQFG QDGPISVHCS AGVGRTGVFI
1860 1870 1880 1890 1900
TLSIVLERMR YEGVVDIFQT VKVLRTQRPA MVQTEDEYQF CFQAALEYLG

SFDHYAT
Length:1,907
Mass (Da):211,904
Last modified:April 8, 2008 - v1
Checksum:i725C016196E22D1A
GO
Isoform 2 (identifier: B0V2N1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1519-1521: Missing.

Show »
Length:1,904
Mass (Da):211,579
Checksum:i276B40675B8B37FC
GO
Isoform 3 (identifier: B0V2N1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     604-604: K → I
     605-1010: Missing.

Show »
Length:1,501
Mass (Da):168,298
Checksum:i4443E1DDFE83BF41
GO
Isoform 4 (identifier: B0V2N1-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     604-604: K → I
     605-1010: Missing.
     1284-1287: Missing.

Show »
Length:1,497
Mass (Da):167,871
Checksum:i07C97C891E1BE761
GO
Isoform 5 (identifier: B0V2N1-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1315: Missing.

Show »
Length:592
Mass (Da):68,104
Checksum:iE24908FB00CE3F16
GO
Isoform 6 (identifier: B0V2N1-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     624-669: Missing.

Show »
Length:1,861
Mass (Da):206,825
Checksum:i64C415721228AF18
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti597 – 5971R → H in CAA57732. (PubMed:7529177)Curated
Sequence conflicti758 – 7581P → A in CAA57732. (PubMed:7529177)Curated
Sequence conflicti834 – 8341A → G in CAA57732. (PubMed:7529177)Curated
Sequence conflicti853 – 8531A → R in CAA57732. (PubMed:7529177)Curated
Sequence conflicti887 – 8871A → G in CAA57732. (PubMed:7529177)Curated
Sequence conflicti981 – 9811A → G in CAA57732. (PubMed:7529177)Curated
Sequence conflicti1169 – 11713RSL → QHV in CAA57732. (PubMed:7529177)Curated
Sequence conflicti1502 – 15021E → G in CAA57732. (PubMed:7529177)Curated
Sequence conflicti1609 – 16091G → S in CAA57732. (PubMed:7529177)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 13151315Missing in isoform 5. 1 PublicationVSP_036057Add
BLAST
Alternative sequencei604 – 6041K → I in isoform 3 and isoform 4. 1 PublicationVSP_036058
Alternative sequencei605 – 1010406Missing in isoform 3 and isoform 4. 1 PublicationVSP_036059Add
BLAST
Alternative sequencei624 – 66946Missing in isoform 6. 1 PublicationVSP_036060Add
BLAST
Alternative sequencei1284 – 12874Missing in isoform 4. 1 PublicationVSP_036061
Alternative sequencei1519 – 15213Missing in isoform 2. 1 PublicationVSP_036062

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82288 mRNA. Translation: CAA57732.1.
D28530 mRNA. Translation: BAA05886.1.
AK159320 mRNA. Translation: BAE34987.1.
AK169714 mRNA. Translation: BAE41325.1.
CT009637 Genomic DNA. Translation: CAQ12196.1.
CT009637 Genomic DNA. Translation: CAQ12197.1.
BC052462 mRNA. Translation: AAH52462.1.
BC083188 mRNA. Translation: AAH83188.1.
CCDSiCCDS37664.1. [B0V2N1-1]
CCDS57103.1. [B0V2N1-3]
RefSeqiNP_001239382.1. NM_001252453.1. [B0V2N1-3]
NP_001239384.1. NM_001252455.1. [B0V2N1-4]
NP_001239385.1. NM_001252456.1. [B0V2N1-3]
NP_035348.2. NM_011218.2. [B0V2N1-1]
UniGeneiMm.258771.

Genome annotation databases

EnsembliENSMUST00000067538; ENSMUSP00000064048; ENSMUSG00000013236. [B0V2N1-1]
ENSMUST00000086828; ENSMUSP00000084038; ENSMUSG00000013236. [B0V2N1-3]
GeneIDi19280.
KEGGimmu:19280.
UCSCiuc008dbx.3. mouse. [B0V2N1-3]
uc008dby.2. mouse. [B0V2N1-1]
uc008dca.2. mouse. [B0V2N1-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82288 mRNA. Translation: CAA57732.1 .
D28530 mRNA. Translation: BAA05886.1 .
AK159320 mRNA. Translation: BAE34987.1 .
AK169714 mRNA. Translation: BAE41325.1 .
CT009637 Genomic DNA. Translation: CAQ12196.1 .
CT009637 Genomic DNA. Translation: CAQ12197.1 .
BC052462 mRNA. Translation: AAH52462.1 .
BC083188 mRNA. Translation: AAH83188.1 .
CCDSi CCDS37664.1. [B0V2N1-1 ]
CCDS57103.1. [B0V2N1-3 ]
RefSeqi NP_001239382.1. NM_001252453.1. [B0V2N1-3 ]
NP_001239384.1. NM_001252455.1. [B0V2N1-4 ]
NP_001239385.1. NM_001252456.1. [B0V2N1-3 ]
NP_035348.2. NM_011218.2. [B0V2N1-1 ]
UniGenei Mm.258771.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3SR9 X-ray 2.40 A 1326-1901 [» ]
ProteinModelPortali B0V2N1.
SMRi B0V2N1. Positions 29-807, 813-902, 907-1004, 1326-1901.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi B0V2N1. 3 interactions.
MINTi MINT-129725.

PTM databases

PhosphoSitei B0V2N1.

Proteomic databases

MaxQBi B0V2N1.
PaxDbi B0V2N1.
PRIDEi B0V2N1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000067538 ; ENSMUSP00000064048 ; ENSMUSG00000013236 . [B0V2N1-1 ]
ENSMUST00000086828 ; ENSMUSP00000084038 ; ENSMUSG00000013236 . [B0V2N1-3 ]
GeneIDi 19280.
KEGGi mmu:19280.
UCSCi uc008dbx.3. mouse. [B0V2N1-3 ]
uc008dby.2. mouse. [B0V2N1-1 ]
uc008dca.2. mouse. [B0V2N1-4 ]

Organism-specific databases

CTDi 5802.
MGIi MGI:97815. Ptprs.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00760000118900.
HOVERGENi HBG053758.
InParanoidi B0V2N1.
KOi K06778.
OMAi GGTERCG.
OrthoDBi EOG7M98FB.
PhylomeDBi B0V2N1.
TreeFami TF312900.

Enzyme and pathway databases

Reactomei REACT_196606. ECM proteoglycans.

Miscellaneous databases

NextBioi 296192.
PROi B0V2N1.
SOURCEi Search...

Gene expression databases

Bgeei B0V2N1.
ExpressionAtlasi B0V2N1. baseline and differential.
Genevestigatori B0V2N1.

Family and domain databases

Gene3Di 2.60.40.10. 10 hits.
3.90.190.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 6 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 8 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and tissue-specific RNA processing of a murine receptor-type protein tyrosine phosphatase."
    Wagner J., Boerboom D., Tremblay M.L.
    Eur. J. Biochem. 226:773-782(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 6), DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Embryonic kidney.
  2. "Expression of a novel murine receptor protein tyrosine phosphatase in the thymus."
    Ogata M., Sawada M., Hamaoka T.
    Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Thymus.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1337-1907.
    Strain: C57BL/6J and NOD.
    Tissue: Thymus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiPTPRS_MOUSE
AccessioniPrimary (citable) accession number: B0V2N1
Secondary accession number(s): Q3TEC3
, Q3TXC9, Q4JFC7, Q5XJV4, Q64503, Q64699, Q7TT17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: April 8, 2008
Last modified: November 26, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3