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B0V2N1

- PTPRS_MOUSE

UniProt

B0V2N1 - PTPRS_MOUSE

Protein

Receptor-type tyrosine-protein phosphatase S

Gene

Ptprs

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Interacts with LAR-interacting protein LIP.1.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei1197 – 11982CleavageBy similarity
    Binding sitei1516 – 15161SubstrateBy similarity
    Active sitei1548 – 15481Phosphocysteine intermediateBy similarity
    Binding sitei1592 – 15921SubstrateBy similarity
    Active sitei1839 – 18391Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. cerebellum development Source: MGI
    3. cerebral cortex development Source: MGI
    4. corpus callosum development Source: MGI
    5. hippocampus development Source: MGI
    6. spinal cord development Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase, Receptor

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_196606. ECM proteoglycans.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor-type tyrosine-protein phosphatase S (EC:3.1.3.48)
    Short name:
    R-PTP-S
    Alternative name(s):
    PTPNU-3
    Receptor-type tyrosine-protein phosphatase sigma
    Short name:
    R-PTP-sigma
    Gene namesi
    Name:Ptprs
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:97815. Ptprs.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 19071878Receptor-type tyrosine-protein phosphatase SPRO_0000358321Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi54 ↔ 107PROSITE-ProRule annotation
    Disulfide bondi156 ↔ 207PROSITE-ProRule annotation
    Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi253 ↔ 298PROSITE-ProRule annotation
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi720 – 7201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi916 – 9161N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiB0V2N1.
    PaxDbiB0V2N1.
    PRIDEiB0V2N1.

    PTM databases

    PhosphoSiteiB0V2N1.

    Expressioni

    Tissue specificityi

    Isoform 1 and isoform 6 are predominantly expressed in the brain (cerebrum and cerebellum) and to a lesser extent in the heart and skeletal muscle. Also found in neuronal-derived cell lines.1 Publication

    Developmental stagei

    Expression is seen in embryos between 8 dpc and 16 dpc and a peak expression is seen at 14 dpc.1 Publication

    Gene expression databases

    ArrayExpressiB0V2N1.
    BgeeiB0V2N1.
    GenevestigatoriB0V2N1.

    Interactioni

    Subunit structurei

    Interacts with PPFIA1, PPFIA2 and PPFIA3.By similarity

    Protein-protein interaction databases

    IntActiB0V2N1. 3 interactions.
    MINTiMINT-129725.

    Structurei

    Secondary structure

    1
    1907
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi1337 – 135822
    Helixi1368 – 13714
    Turni1373 – 13753
    Helixi1376 – 13783
    Helixi1388 – 13903
    Beta strandi1391 – 13933
    Turni1401 – 14044
    Beta strandi1405 – 14139
    Beta strandi1416 – 14238
    Helixi1428 – 14303
    Helixi1431 – 144010
    Beta strandi1445 – 14484
    Beta strandi1452 – 14543
    Beta strandi1457 – 14593
    Beta strandi1466 – 14727
    Beta strandi1475 – 148410
    Beta strandi1486 – 149914
    Beta strandi1503 – 15119
    Beta strandi1516 – 15183
    Helixi1524 – 153512
    Beta strandi1544 – 155310
    Helixi1554 – 156815
    Beta strandi1571 – 15744
    Helixi1576 – 15849
    Helixi1594 – 160916
    Helixi1617 – 16193
    Helixi1620 – 16278
    Helixi1638 – 16447
    Turni1657 – 16593
    Turni1665 – 16673
    Beta strandi1671 – 16733
    Turni1677 – 16793
    Beta strandi1696 – 17005
    Beta strandi1703 – 17053
    Beta strandi1709 – 17124
    Turni1717 – 17193
    Helixi1720 – 172910
    Beta strandi1734 – 17374
    Beta strandi1744 – 17474
    Beta strandi1755 – 17573
    Beta strandi1759 – 17613
    Beta strandi1764 – 177310
    Beta strandi1775 – 178612
    Turni1787 – 17893
    Beta strandi1792 – 18009
    Beta strandi1805 – 18073
    Helixi1813 – 182816
    Beta strandi1835 – 18439
    Helixi1844 – 186118
    Helixi1867 – 18759
    Helixi1885 – 190016

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3SR9X-ray2.40A1326-1901[»]
    ProteinModelPortaliB0V2N1.
    SMRiB0V2N1. Positions 29-807, 813-902, 907-1004, 1326-1901.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 12571228ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1279 – 1907629CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1258 – 127821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 12391Ig-like C2-type 1Add
    BLAST
    Domaini135 – 22490Ig-like C2-type 2Add
    BLAST
    Domaini232 – 31483Ig-like C2-type 3Add
    BLAST
    Domaini321 – 41191Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini416 – 51095Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini514 – 60390Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini608 – 70598Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini710 – 809100Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini810 – 90697Fibronectin type-III 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini907 – 1008102Fibronectin type-III 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini1011 – 109585Fibronectin type-III 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini1352 – 1607256Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1639 – 1898260Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1548 – 15547Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 8 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    GeneTreeiENSGT00590000082937.
    HOVERGENiHBG053758.
    InParanoidiB0V2N1.
    KOiK06778.
    OMAiGGTERCG.
    OrthoDBiEOG7M98FB.
    PhylomeDBiB0V2N1.
    TreeFamiTF312900.

    Family and domain databases

    Gene3Di2.60.40.10. 10 hits.
    3.90.190.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00041. fn3. 6 hits.
    PF07679. I-set. 3 hits.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00060. FN3. 8 hits.
    SM00408. IGc2. 3 hits.
    SM00194. PTPc. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 5 hits.
    SSF52799. SSF52799. 2 hits.
    PROSITEiPS50853. FN3. 8 hits.
    PS50835. IG_LIKE. 3 hits.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: B0V2N1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPTWSPSVV SVVGPVGLFL VLLARGCLAE EPPRFIREPK DQIGVSGGVA     50
    SFVCQATGDP KPRVTWNKKG KKVNSQRFET IDFDESSGAV LRIQPLRTPR 100
    DENVYECVAQ NSVGEITIHA KLTVLREDQL PPGFPNIDMG PQLKVVERTR 150
    TATMLCAASG NPDPEITWFK DFLPVDPSAS NGRIKQLRSG ALQIESSEET 200
    DQGKYECVAT NSAGVRYSSP ANLYVRVRRV APRFSILPMS HEIMPGGNVN 250
    ITCVAVGSPM PYVKWMQGAE DLTPEDDMPV GRNVLELTDV KDSANYTCVA 300
    MSSLGVIEAV AQITVKSLPK APGTPVVTEN TATSITVTWD SGNPDPVSYY 350
    VIEYKSKSQD GPYQIKEDIT TTRYSIGGLS PNSEYEIWVS AVNSIGQGPP 400
    SESVVTRTGE QAPASAPRNV QARMLSATTM IVQWEEPVEP NGLIRGYRVY 450
    YTMEPEHPVG NWQKHNVDDS LLTTVGSLLE DETYTVRVLA FTSVGDGPLS 500
    DPIQVKTQQG VPGQPMNLRA EAKSETSIGL SWSAPRQESV IKYELLFREG 550
    DRGREVGRTF DPTTAFVVED LKPNTEYAFR LAARSPQGLG AFTAVVRQRT 600
    LQAKPSAPPQ DVKCTSLRST AILVSWRPPP PETHNGALVG YSVRYRPLGS 650
    EDPDPKEVNN IPPTTTQILL EALEKWTEYR VTAVAYTEVG PGPESSPVVV 700
    RTDEDVPSAP PRKVEAEALN ATAIRVLWRS PTPGRQHGQI RGYQVHYVRM 750
    EGAEARGPPR IKDIMLADAQ EMVITNLQPE TAYSITVAAY TMKGDGARSK 800
    PKVVVTKGAV LGRPTLSVQQ TPEGSLLARW EPPADAAEDP VLGYRLQFGR 850
    EDAAPATLEL AAWERRFAAP AHKGATYVFR LAARGRAGLG EEAAAALSIP 900
    EDAPRGFPQI LGAAGNVSAG SVLLRWLPPV PAERNGAIIK YTVSVREAGA 950
    PGPATETELA AAAQPGAETA LTLRGLRPET AYELRVRAHT RRGPGPFSPP 1000
    LRYRLARDPV SPKNFKVKMI MKTSVLLSWE FPDNYNSPTP YKIQYNGLTL 1050
    DVDGRTTKKL ITHLKPHTFY NFVLTNRGSS LGGLQQTVTA RTAFNMLSGK 1100
    PSVAPKPDND GFIVVYLPDG QSPVTVQNYF IVMVPLRKSR GGQFPVLLGS 1150
    PEDMDLEELI QDISRLQRRS LRHSRQLEVP RPYIAARFSI LPAVFHPGNQ 1200
    KQYGGFDNRG LEPGHRYVLF VLAVLQKNEP TFAASPFSDP FQLDNPDPQP 1250
    IVDGEEGLIW VIGPVLAVVF IICIVIAILL YKNKPDSKRK DSEPRTKCLL 1300
    NNADLAPHHP KDPVEMRRIN FQTPGMLSHP PIPITDMAEH MERLKANDSL 1350
    KLSQEYESID PGQQFTWEHS NLEANKPKNR YANVIAYDHS RVILQPLEGI 1400
    MGSDYINANY VDGYRRQNAY IATQGPLPET FGDFWRMVWE QRSATVVMMT 1450
    RLEEKSRIKC DQYWPNRGTE TYGFIQVTLL DTMELATFCV RTFSLHKNGS 1500
    SEKREVRHFQ FTAWPDHGVP EYPTPFLAFL RRVKTCNPPD AGPIVVHCSA 1550
    GVGRTGCFIV IDAMLERIKT EKTVDVYGHV TLMRSQRNYM VQTEDQYGFI 1600
    HEALLEAVGC GNTEVPARSL YTYIQKLAQV EPGEHVTGME LEFKRLASSK 1650
    AHTSRFITAS LPCNKFKNRL VNILPYESSR VCLQPIRGVE GSDYINASFI 1700
    DGYRQQKAYI ATQGPLAETT EDFWRALWEN NSTIVVMLTK LREMGREKCH 1750
    QYWPAERSAR YQYFVVDPMA EYNMPQYILR EFKVTDARDG QSRTVRQFQF 1800
    TDWPEQGAPK SGEGFIDFIG QVHKTKEQFG QDGPISVHCS AGVGRTGVFI 1850
    TLSIVLERMR YEGVVDIFQT VKVLRTQRPA MVQTEDEYQF CFQAALEYLG 1900
    SFDHYAT 1907
    Length:1,907
    Mass (Da):211,904
    Last modified:April 8, 2008 - v1
    Checksum:i725C016196E22D1A
    GO
    Isoform 2 (identifier: B0V2N1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1519-1521: Missing.

    Show »
    Length:1,904
    Mass (Da):211,579
    Checksum:i276B40675B8B37FC
    GO
    Isoform 3 (identifier: B0V2N1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         604-604: K → I
         605-1010: Missing.

    Show »
    Length:1,501
    Mass (Da):168,298
    Checksum:i4443E1DDFE83BF41
    GO
    Isoform 4 (identifier: B0V2N1-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         604-604: K → I
         605-1010: Missing.
         1284-1287: Missing.

    Show »
    Length:1,497
    Mass (Da):167,871
    Checksum:i07C97C891E1BE761
    GO
    Isoform 5 (identifier: B0V2N1-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1315: Missing.

    Show »
    Length:592
    Mass (Da):68,104
    Checksum:iE24908FB00CE3F16
    GO
    Isoform 6 (identifier: B0V2N1-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         624-669: Missing.

    Show »
    Length:1,861
    Mass (Da):206,825
    Checksum:i64C415721228AF18
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti597 – 5971R → H in CAA57732. (PubMed:7529177)Curated
    Sequence conflicti758 – 7581P → A in CAA57732. (PubMed:7529177)Curated
    Sequence conflicti834 – 8341A → G in CAA57732. (PubMed:7529177)Curated
    Sequence conflicti853 – 8531A → R in CAA57732. (PubMed:7529177)Curated
    Sequence conflicti887 – 8871A → G in CAA57732. (PubMed:7529177)Curated
    Sequence conflicti981 – 9811A → G in CAA57732. (PubMed:7529177)Curated
    Sequence conflicti1169 – 11713RSL → QHV in CAA57732. (PubMed:7529177)Curated
    Sequence conflicti1502 – 15021E → G in CAA57732. (PubMed:7529177)Curated
    Sequence conflicti1609 – 16091G → S in CAA57732. (PubMed:7529177)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 13151315Missing in isoform 5. 1 PublicationVSP_036057Add
    BLAST
    Alternative sequencei604 – 6041K → I in isoform 3 and isoform 4. 1 PublicationVSP_036058
    Alternative sequencei605 – 1010406Missing in isoform 3 and isoform 4. 1 PublicationVSP_036059Add
    BLAST
    Alternative sequencei624 – 66946Missing in isoform 6. 1 PublicationVSP_036060Add
    BLAST
    Alternative sequencei1284 – 12874Missing in isoform 4. 1 PublicationVSP_036061
    Alternative sequencei1519 – 15213Missing in isoform 2. 1 PublicationVSP_036062

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X82288 mRNA. Translation: CAA57732.1.
    D28530 mRNA. Translation: BAA05886.1.
    AK159320 mRNA. Translation: BAE34987.1.
    AK169714 mRNA. Translation: BAE41325.1.
    CT009637 Genomic DNA. Translation: CAQ12196.1.
    CT009637 Genomic DNA. Translation: CAQ12197.1.
    BC052462 mRNA. Translation: AAH52462.1.
    BC083188 mRNA. Translation: AAH83188.1.
    CCDSiCCDS37664.1. [B0V2N1-1]
    CCDS57103.1. [B0V2N1-3]
    RefSeqiNP_001239382.1. NM_001252453.1. [B0V2N1-3]
    NP_001239384.1. NM_001252455.1. [B0V2N1-4]
    NP_001239385.1. NM_001252456.1. [B0V2N1-3]
    NP_035348.2. NM_011218.2. [B0V2N1-1]
    UniGeneiMm.258771.

    Genome annotation databases

    EnsembliENSMUST00000067538; ENSMUSP00000064048; ENSMUSG00000013236. [B0V2N1-1]
    ENSMUST00000086828; ENSMUSP00000084038; ENSMUSG00000013236. [B0V2N1-3]
    GeneIDi19280.
    KEGGimmu:19280.
    UCSCiuc008dbx.3. mouse. [B0V2N1-3]
    uc008dby.2. mouse. [B0V2N1-1]
    uc008dca.2. mouse. [B0V2N1-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X82288 mRNA. Translation: CAA57732.1 .
    D28530 mRNA. Translation: BAA05886.1 .
    AK159320 mRNA. Translation: BAE34987.1 .
    AK169714 mRNA. Translation: BAE41325.1 .
    CT009637 Genomic DNA. Translation: CAQ12196.1 .
    CT009637 Genomic DNA. Translation: CAQ12197.1 .
    BC052462 mRNA. Translation: AAH52462.1 .
    BC083188 mRNA. Translation: AAH83188.1 .
    CCDSi CCDS37664.1. [B0V2N1-1 ]
    CCDS57103.1. [B0V2N1-3 ]
    RefSeqi NP_001239382.1. NM_001252453.1. [B0V2N1-3 ]
    NP_001239384.1. NM_001252455.1. [B0V2N1-4 ]
    NP_001239385.1. NM_001252456.1. [B0V2N1-3 ]
    NP_035348.2. NM_011218.2. [B0V2N1-1 ]
    UniGenei Mm.258771.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3SR9 X-ray 2.40 A 1326-1901 [» ]
    ProteinModelPortali B0V2N1.
    SMRi B0V2N1. Positions 29-807, 813-902, 907-1004, 1326-1901.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi B0V2N1. 3 interactions.
    MINTi MINT-129725.

    PTM databases

    PhosphoSitei B0V2N1.

    Proteomic databases

    MaxQBi B0V2N1.
    PaxDbi B0V2N1.
    PRIDEi B0V2N1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000067538 ; ENSMUSP00000064048 ; ENSMUSG00000013236 . [B0V2N1-1 ]
    ENSMUST00000086828 ; ENSMUSP00000084038 ; ENSMUSG00000013236 . [B0V2N1-3 ]
    GeneIDi 19280.
    KEGGi mmu:19280.
    UCSCi uc008dbx.3. mouse. [B0V2N1-3 ]
    uc008dby.2. mouse. [B0V2N1-1 ]
    uc008dca.2. mouse. [B0V2N1-4 ]

    Organism-specific databases

    CTDi 5802.
    MGIi MGI:97815. Ptprs.

    Phylogenomic databases

    eggNOGi COG5599.
    GeneTreei ENSGT00590000082937.
    HOVERGENi HBG053758.
    InParanoidi B0V2N1.
    KOi K06778.
    OMAi GGTERCG.
    OrthoDBi EOG7M98FB.
    PhylomeDBi B0V2N1.
    TreeFami TF312900.

    Enzyme and pathway databases

    Reactomei REACT_196606. ECM proteoglycans.

    Miscellaneous databases

    NextBioi 296192.
    PROi B0V2N1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi B0V2N1.
    Bgeei B0V2N1.
    Genevestigatori B0V2N1.

    Family and domain databases

    Gene3Di 2.60.40.10. 10 hits.
    3.90.190.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00041. fn3. 6 hits.
    PF07679. I-set. 3 hits.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00060. FN3. 8 hits.
    SM00408. IGc2. 3 hits.
    SM00194. PTPc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 5 hits.
    SSF52799. SSF52799. 2 hits.
    PROSITEi PS50853. FN3. 8 hits.
    PS50835. IG_LIKE. 3 hits.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view ]
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    Publicationsi

    1. "Molecular cloning and tissue-specific RNA processing of a murine receptor-type protein tyrosine phosphatase."
      Wagner J., Boerboom D., Tremblay M.L.
      Eur. J. Biochem. 226:773-782(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 6), DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Embryonic kidney.
    2. "Expression of a novel murine receptor protein tyrosine phosphatase in the thymus."
      Ogata M., Sawada M., Hamaoka T.
      Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Thymus.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1337-1907.
      Strain: C57BL/6J and NOD.
      Tissue: Thymus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiPTPRS_MOUSE
    AccessioniPrimary (citable) accession number: B0V2N1
    Secondary accession number(s): Q3TEC3
    , Q3TXC9, Q4JFC7, Q5XJV4, Q64503, Q64699, Q7TT17
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 16, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3