ID   B0V218_DANRE            Unreviewed;       475 AA.
AC   B0V218; A0A8M1NB19; E9QDS7;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 116.
DE   SubName: Full=Abl interactor 2 {ECO:0000313|RefSeq:NP_001070054.2};
DE   SubName: Full=Abl-interactor 2a {ECO:0000313|Ensembl:ENSDARP00000118040};
GN   Name=abi2a {ECO:0000313|Ensembl:ENSDARP00000118040,
GN   ECO:0000313|RefSeq:NP_001070054.2,
GN   ECO:0000313|ZFIN:ZDB-GENE-060929-192};
GN   Synonyms=zgc:153663 {ECO:0000313|RefSeq:NP_001070054.2};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000118040};
RN   [1] {ECO:0000313|RefSeq:NP_001070054.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001070054.2};
RX   PubMed=21208897;
RA   Ulvila J., Vanha-aho L.M., Kleino A., Vaha-Makila M., Vuoksio M.,
RA   Eskelinen S., Hultmark D., Kocks C., Hallman M., Parikka M., Ramet M.;
RT   "Cofilin regulator 14-3-3zeta is an evolutionarily conserved protein
RT   required for phagocytosis and microbial resistance.";
RL   J. Leukoc. Biol. 89:649-659(2011).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000118040, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000118040};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RG   Genome Reference Consortium Zebrafish;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA   Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA   Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA   Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA   Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA   Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA   Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA   Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA   Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA   Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA   Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA   Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA   Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA   Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA   Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA   Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA   Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA   Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA   Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA   Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000118040}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000118040};
RG   Ensembl;
RL   Submitted (MAY-2013) to UniProtKB.
RN   [4] {ECO:0000313|RefSeq:NP_001070054.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001070054.2};
RX   PubMed=28252024;
RA   Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA   Choudhary J.S., Emes R.D., Grant S.G.;
RT   "Evolution of complexity in the zebrafish synapse proteome.";
RL   Nat. Commun. 8:14613-14613(2017).
RN   [5] {ECO:0000313|RefSeq:NP_001070054.2}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001070054.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, filopodium
CC       {ECO:0000256|ARBA:ARBA00004486}. Cell projection, lamellipodium
CC       {ECO:0000256|ARBA:ARBA00004510}.
CC   -!- SIMILARITY: Belongs to the ABI family. {ECO:0000256|ARBA:ARBA00010020}.
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DR   EMBL; BX571704; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR936378; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001070054.2; NM_001076586.2.
DR   PaxDb; 7955-ENSDARP00000118040; -.
DR   Ensembl; ENSDART00000081015.6; ENSDARP00000075458.5; ENSDARG00000058207.7.
DR   Ensembl; ENSDART00000141314.3; ENSDARP00000118040.1; ENSDARG00000058207.7.
DR   GeneID; 767646; -.
DR   KEGG; dre:767646; -.
DR   AGR; ZFIN:ZDB-GENE-060929-192; -.
DR   CTD; 767646; -.
DR   ZFIN; ZDB-GENE-060929-192; abi2a.
DR   eggNOG; KOG2546; Eukaryota.
DR   OrthoDB; 3028771at2759; -.
DR   TreeFam; TF314303; -.
DR   Proteomes; UP000000437; Alternate scaffold 9.
DR   Proteomes; UP000000437; Chromosome 9.
DR   Bgee; ENSDARG00000058207; Expressed in mature ovarian follicle and 24 other cell types or tissues.
DR   GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR   GO; GO:0030027; C:lamellipodium; IBA:GO_Central.
DR   GO; GO:0017124; F:SH3 domain binding; IBA:GO_Central.
DR   CDD; cd11972; SH3_Abi2; 1.
DR   Gene3D; 6.10.140.1620; -; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR028457; ABI.
DR   InterPro; IPR035726; Abi2_SH3.
DR   InterPro; IPR012849; Abl-interactor_HHR_dom.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR000727; T_SNARE_dom.
DR   PANTHER; PTHR10460:SF26; ABL INTERACTOR 2; 1.
DR   PANTHER; PTHR10460; ABL INTERACTOR FAMILY MEMBER; 1.
DR   Pfam; PF07815; Abi_HHR; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00499; P67PHOX.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50002; SH3; 1.
DR   PROSITE; PS50192; T_SNARE; 1.
PE   3: Inferred from homology;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          45..107
FT                   /note="T-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000259|PROSITE:PS50192"
FT   DOMAIN          413..472
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          165..344
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          360..409
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        215..259
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        306..337
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   475 AA;  52255 MW;  F549DF58F1EA5844 CRC64;
     MAELQMLLEE EIPAGRRALL DSFTNLDRVA EYCESNYVQA PDKHVALEET KNYTTQSLAS
     VAYLINTLAN NVLQMLDIQA SQLRRMESSI NHISQTVDIH KEKVARREIG ILTTNKNTSR
     THKIIAPANP ERPVRYIRKP IDYSMLDDIG HGVKVNTQNM KMGSLLRTTP PTQKPPSPPM
     AGKGTIGRHS PYRTLEPVRP PVVPNDYVPS PTRNMVPILH QSPVRTASVN QRNRTYSSGS
     SGGSHPSSRS SSRENSGSGS VGLPIAVPTP SPPSAFPGAP QFYSMNRPVP RQTAPSVGGS
     LPYRRPPSLT GQTSMPPSQQ NGGPYYNQSQ ASVAPPPPSV LQITPQLPLT GFVARVQETI
     TDAPPPSPPS EEPMFDDTQN PAAPPEGYEE EESSVVEYSD PYAEEDPPWA PQTYLEKVVA
     IYDYVRDKED ELSFQEGAII YVIKKNDDGW YEGVMSGTTG LFPGNYVESI MHYTE
//