B0UZC8 (VWC2L_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
von Willebrand factor C domain-containing protein 2-like

Gene names

Name:	vwc2l
ORF Names:	si:ch211-207d8.1

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in bone differentiation and matrix mineralization By similarity. May play a role in neural development. Ref.1
Subcellular location	Secreted By similarity. Cell junction › synapse By similarity.
Developmental stage	At 36 hpf, expressed predominantlyin the brain, including several discrete regions in the forebrain, midbrain and hindbrain. Ref.1
Sequence similarities	Contains 2 VWFC domains.

Ontologies

Keywords
Cellular component	Cell junction Secreted Synapse
Domain	Repeat Signal
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nervous system development Inferred from mutant phenotype Ref.1. Source: ZFIN
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell synapse Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 223	202	von Willebrand factor C domain-containing protein 2-like		PRO_0000348063
Regions
	Domain	51 – 110	60	VWFC 1
	Domain	114 – 172	59	VWFC 2

Sequences

	Sequence		Length	Mass (Da)
	B0UZC8 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 3C34E9E9A4B43640	FASTA	223	24,509
	10 20 30 40 50 60 MGPFLPAICV VLLALNAAVS PASVGPEDYP AADEAERTAN NDIIFDDYRG KGCVDDSGFV 70 80 90 100 110 120 YKLGERFFPG HSNCPCVCTE DGPVCDQPEC PKIHPKCTKV EHNGCCPECK EVKNFCEYRG 130 140 150 160 170 180 KTYKILEEFK PSPCEWCRCE PNNEVHCVVA DCAVPECVNP VYEPEQCCPI CKNGPNCFAG 190 200 210 220 TTIIPAGIEV KVDDCTICRC HSGDWWKPAQ CLRRECLNGQ ATS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family." Miwa H., Miyake A., Kouta Y., Shimada A., Yamashita Y., Nakayama Y., Yamauchi H., Konishi M., Itoh N. FEBS Lett. 583:3643-3648(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
[2]	The Danio rerio sequencing project at the Sanger Institute Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AB.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB428728 mRNA. Translation: BAH04287.1. CR753890 Genomic DNA. Translation: CAQ13566.1.
IPI	IPI00865581.
RefSeq	NP_001122036.1. NM_001128564.1.
UniGene	Dr.148397.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	7955.ENSDARP00000091167.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000100394; ENSDARP00000091167; ENSDARG00000069134. ENSDART00000132911; ENSDARP00000115777; ENSDARG00000069134.
GeneID	100148652.
KEGG	dre:100148652.
Organism-specific databases
CTD	402117.
ZFIN	ZDB-GENE-081104-169. vwc2l.
Phylogenomic databases
eggNOG	NOG83498.
GeneTree	ENSGT00450000040255.
HOGENOM	HOG000036086.
HOVERGEN	HBG068398.
OMA	CLRRECL.
OrthoDB	EOG40ZQZV.
Gene expression databases
Bgee	B0UZC8.
Family and domain databases
InterPro	IPR001007. VWF_C. [Graphical view]
Pfam	PF00093. VWC. 1 hit. [Graphical view]
SMART	SM00214. VWC. 1 hit. [Graphical view]
PROSITE	PS01208. VWFC_1. 1 hit. PS50184. VWFC_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20792279.

Entry information

Entry name

VWC2L_DANRE

Accession

Primary (citable) accession number: B0UZC8
Secondary accession number(s): B7X9K3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	April 8, 2008
Last modified:	May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program