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Protein

von Willebrand factor C domain-containing protein 2-like

Gene

vwc2l

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in bone differentiation and matrix mineralization (By similarity). May play a role in neural development.By similarity1 Publication

GO - Biological processi

  • nervous system development Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
von Willebrand factor C domain-containing protein 2-like
Gene namesi
Name:vwc2l
ORF Names:si:ch211-207d8.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-081104-169. vwc2l.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Secreted, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000034806322 – 223von Willebrand factor C domain-containing protein 2-likeAdd BLAST202

Proteomic databases

PaxDbiB0UZC8.

Expressioni

Developmental stagei

At 36 hpf, expressed predominantlyin the brain, including several discrete regions in the forebrain, midbrain and hindbrain.1 Publication

Gene expression databases

BgeeiENSDARG00000069134.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 110VWFC 1PROSITE-ProRule annotationAdd BLAST60
Domaini114 – 172VWFC 2PROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Contains 2 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IHPX. Eukaryota.
ENOG410XTA9. LUCA.
GeneTreeiENSGT00720000108792.
HOGENOMiHOG000036086.
HOVERGENiHBG068398.
InParanoidiB0UZC8.
OMAiCLRRECL.
OrthoDBiEOG091G0Q3M.
PhylomeDBiB0UZC8.
TreeFamiTF329913.

Family and domain databases

InterProiIPR001007. VWF_dom.
[Graphical view]
PfamiPF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00214. VWC. 2 hits.
[Graphical view]
PROSITEiPS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0UZC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPFLPAICV VLLALNAAVS PASVGPEDYP AADEAERTAN NDIIFDDYRG
60 70 80 90 100
KGCVDDSGFV YKLGERFFPG HSNCPCVCTE DGPVCDQPEC PKIHPKCTKV
110 120 130 140 150
EHNGCCPECK EVKNFCEYRG KTYKILEEFK PSPCEWCRCE PNNEVHCVVA
160 170 180 190 200
DCAVPECVNP VYEPEQCCPI CKNGPNCFAG TTIIPAGIEV KVDDCTICRC
210 220
HSGDWWKPAQ CLRRECLNGQ ATS
Length:223
Mass (Da):24,509
Last modified:April 8, 2008 - v1
Checksum:i3C34E9E9A4B43640
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB428728 mRNA. Translation: BAH04287.1.
CR753890 Genomic DNA. Translation: CAQ13566.1.
RefSeqiNP_001122036.1. NM_001128564.1.
UniGeneiDr.148397.

Genome annotation databases

EnsembliENSDART00000132911; ENSDARP00000115777; ENSDARG00000069134.
GeneIDi100148652.
KEGGidre:100148652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB428728 mRNA. Translation: BAH04287.1.
CR753890 Genomic DNA. Translation: CAQ13566.1.
RefSeqiNP_001122036.1. NM_001128564.1.
UniGeneiDr.148397.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiB0UZC8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000132911; ENSDARP00000115777; ENSDARG00000069134.
GeneIDi100148652.
KEGGidre:100148652.

Organism-specific databases

CTDi402117.
ZFINiZDB-GENE-081104-169. vwc2l.

Phylogenomic databases

eggNOGiENOG410IHPX. Eukaryota.
ENOG410XTA9. LUCA.
GeneTreeiENSGT00720000108792.
HOGENOMiHOG000036086.
HOVERGENiHBG068398.
InParanoidiB0UZC8.
OMAiCLRRECL.
OrthoDBiEOG091G0Q3M.
PhylomeDBiB0UZC8.
TreeFamiTF329913.

Miscellaneous databases

PROiB0UZC8.

Gene expression databases

BgeeiENSDARG00000069134.

Family and domain databases

InterProiIPR001007. VWF_dom.
[Graphical view]
PfamiPF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00214. VWC. 2 hits.
[Graphical view]
PROSITEiPS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVWC2L_DANRE
AccessioniPrimary (citable) accession number: B0UZC8
Secondary accession number(s): B7X9K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: April 8, 2008
Last modified: September 7, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.