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B0UZC8

- VWC2L_DANRE

UniProt

B0UZC8 - VWC2L_DANRE

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Protein

von Willebrand factor C domain-containing protein 2-like

Gene

vwc2l

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in bone differentiation and matrix mineralization (By similarity). May play a role in neural development.By similarity1 Publication

GO - Biological processi

  1. nervous system development Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
von Willebrand factor C domain-containing protein 2-like
Gene namesi
Name:vwc2l
ORF Names:si:ch211-207d8.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-081104-169. vwc2l.

Subcellular locationi

Secreted By similarity. Cell junctionsynapse By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-KW
  3. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Secreted, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 223202von Willebrand factor C domain-containing protein 2-likePRO_0000348063Add
BLAST

Expressioni

Developmental stagei

At 36 hpf, expressed predominantlyin the brain, including several discrete regions in the forebrain, midbrain and hindbrain.1 Publication

Gene expression databases

BgeeiB0UZC8.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000091167.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 11060VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini114 – 17259VWFC 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG83498.
GeneTreeiENSGT00720000108792.
HOGENOMiHOG000036086.
HOVERGENiHBG068398.
InParanoidiB0UZC8.
OMAiCLRRECL.
OrthoDBiEOG73Z2TT.
PhylomeDBiB0UZC8.
TreeFamiTF329913.

Family and domain databases

InterProiIPR001007. VWF_C.
[Graphical view]
PfamiPF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00214. VWC. 1 hit.
[Graphical view]
PROSITEiPS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0UZC8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPFLPAICV VLLALNAAVS PASVGPEDYP AADEAERTAN NDIIFDDYRG
60 70 80 90 100
KGCVDDSGFV YKLGERFFPG HSNCPCVCTE DGPVCDQPEC PKIHPKCTKV
110 120 130 140 150
EHNGCCPECK EVKNFCEYRG KTYKILEEFK PSPCEWCRCE PNNEVHCVVA
160 170 180 190 200
DCAVPECVNP VYEPEQCCPI CKNGPNCFAG TTIIPAGIEV KVDDCTICRC
210 220
HSGDWWKPAQ CLRRECLNGQ ATS
Length:223
Mass (Da):24,509
Last modified:April 8, 2008 - v1
Checksum:i3C34E9E9A4B43640
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB428728 mRNA. Translation: BAH04287.1.
CR753890 Genomic DNA. Translation: CAQ13566.1.
RefSeqiNP_001122036.1. NM_001128564.1.
UniGeneiDr.148397.

Genome annotation databases

EnsembliENSDART00000100394; ENSDARP00000091167; ENSDARG00000069134.
ENSDART00000132911; ENSDARP00000115777; ENSDARG00000069134.
GeneIDi100148652.
KEGGidre:100148652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB428728 mRNA. Translation: BAH04287.1 .
CR753890 Genomic DNA. Translation: CAQ13566.1 .
RefSeqi NP_001122036.1. NM_001128564.1.
UniGenei Dr.148397.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000091167.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000100394 ; ENSDARP00000091167 ; ENSDARG00000069134 .
ENSDART00000132911 ; ENSDARP00000115777 ; ENSDARG00000069134 .
GeneIDi 100148652.
KEGGi dre:100148652.

Organism-specific databases

CTDi 402117.
ZFINi ZDB-GENE-081104-169. vwc2l.

Phylogenomic databases

eggNOGi NOG83498.
GeneTreei ENSGT00720000108792.
HOGENOMi HOG000036086.
HOVERGENi HBG068398.
InParanoidi B0UZC8.
OMAi CLRRECL.
OrthoDBi EOG73Z2TT.
PhylomeDBi B0UZC8.
TreeFami TF329913.

Miscellaneous databases

NextBioi 20792279.
PROi B0UZC8.

Gene expression databases

Bgeei B0UZC8.

Family and domain databases

InterProi IPR001007. VWF_C.
[Graphical view ]
Pfami PF00093. VWC. 1 hit.
[Graphical view ]
SMARTi SM00214. VWC. 1 hit.
[Graphical view ]
PROSITEi PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family."
    Miwa H., Miyake A., Kouta Y., Shimada A., Yamashita Y., Nakayama Y., Yamauchi H., Konishi M., Itoh N.
    FEBS Lett. 583:3643-3648(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.

Entry informationi

Entry nameiVWC2L_DANRE
AccessioniPrimary (citable) accession number: B0UZC8
Secondary accession number(s): B7X9K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3