Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

von Willebrand factor C domain-containing protein 2-like

Gene

vwc2l

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in bone differentiation and matrix mineralization (By similarity). May play a role in neural development.By similarity1 Publication

GO - Biological processi

  • nervous system development Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
von Willebrand factor C domain-containing protein 2-like
Gene namesi
Name:vwc2l
ORF Names:si:ch211-207d8.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-081104-169. vwc2l.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Secreted, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 223202von Willebrand factor C domain-containing protein 2-likePRO_0000348063Add
BLAST

Expressioni

Developmental stagei

At 36 hpf, expressed predominantlyin the brain, including several discrete regions in the forebrain, midbrain and hindbrain.1 Publication

Gene expression databases

BgeeiB0UZC8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 11060VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini114 – 17259VWFC 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG83498.
GeneTreeiENSGT00720000108792.
HOGENOMiHOG000036086.
HOVERGENiHBG068398.
InParanoidiB0UZC8.
OMAiCLRRECL.
OrthoDBiEOG73Z2TT.
PhylomeDBiB0UZC8.
TreeFamiTF329913.

Family and domain databases

InterProiIPR001007. VWF_C.
[Graphical view]
PfamiPF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00214. VWC. 1 hit.
[Graphical view]
PROSITEiPS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0UZC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPFLPAICV VLLALNAAVS PASVGPEDYP AADEAERTAN NDIIFDDYRG
60 70 80 90 100
KGCVDDSGFV YKLGERFFPG HSNCPCVCTE DGPVCDQPEC PKIHPKCTKV
110 120 130 140 150
EHNGCCPECK EVKNFCEYRG KTYKILEEFK PSPCEWCRCE PNNEVHCVVA
160 170 180 190 200
DCAVPECVNP VYEPEQCCPI CKNGPNCFAG TTIIPAGIEV KVDDCTICRC
210 220
HSGDWWKPAQ CLRRECLNGQ ATS
Length:223
Mass (Da):24,509
Last modified:April 8, 2008 - v1
Checksum:i3C34E9E9A4B43640
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB428728 mRNA. Translation: BAH04287.1.
CR753890 Genomic DNA. Translation: CAQ13566.1.
RefSeqiNP_001122036.1. NM_001128564.1.
UniGeneiDr.148397.

Genome annotation databases

EnsembliENSDART00000132911; ENSDARP00000115777; ENSDARG00000069134.
GeneIDi100148652.
KEGGidre:100148652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB428728 mRNA. Translation: BAH04287.1.
CR753890 Genomic DNA. Translation: CAQ13566.1.
RefSeqiNP_001122036.1. NM_001128564.1.
UniGeneiDr.148397.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000132911; ENSDARP00000115777; ENSDARG00000069134.
GeneIDi100148652.
KEGGidre:100148652.

Organism-specific databases

CTDi402117.
ZFINiZDB-GENE-081104-169. vwc2l.

Phylogenomic databases

eggNOGiNOG83498.
GeneTreeiENSGT00720000108792.
HOGENOMiHOG000036086.
HOVERGENiHBG068398.
InParanoidiB0UZC8.
OMAiCLRRECL.
OrthoDBiEOG73Z2TT.
PhylomeDBiB0UZC8.
TreeFamiTF329913.

Miscellaneous databases

NextBioi20792279.
PROiB0UZC8.

Gene expression databases

BgeeiB0UZC8.

Family and domain databases

InterProiIPR001007. VWF_C.
[Graphical view]
PfamiPF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00214. VWC. 1 hit.
[Graphical view]
PROSITEiPS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family."
    Miwa H., Miyake A., Kouta Y., Shimada A., Yamashita Y., Nakayama Y., Yamauchi H., Konishi M., Itoh N.
    FEBS Lett. 583:3643-3648(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.

Entry informationi

Entry nameiVWC2L_DANRE
AccessioniPrimary (citable) accession number: B0UZC8
Secondary accession number(s): B7X9K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: April 8, 2008
Last modified: July 22, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.