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B0UZC8

- VWC2L_DANRE

UniProt

B0UZC8 - VWC2L_DANRE

Protein

von Willebrand factor C domain-containing protein 2-like

Gene

vwc2l

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    May play a role in bone differentiation and matrix mineralization By similarity. May play a role in neural development.By similarity1 Publication

    GO - Biological processi

    1. nervous system development Source: ZFIN

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    von Willebrand factor C domain-containing protein 2-like
    Gene namesi
    Name:vwc2l
    ORF Names:si:ch211-207d8.1
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 9

    Organism-specific databases

    ZFINiZDB-GENE-081104-169. vwc2l.

    Subcellular locationi

    Secreted By similarity. Cell junctionsynapse By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. extracellular region Source: UniProtKB-SubCell
    3. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Secreted, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 223202von Willebrand factor C domain-containing protein 2-likePRO_0000348063Add
    BLAST

    Expressioni

    Developmental stagei

    At 36 hpf, expressed predominantlyin the brain, including several discrete regions in the forebrain, midbrain and hindbrain.1 Publication

    Gene expression databases

    BgeeiB0UZC8.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000091167.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini51 – 11060VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini114 – 17259VWFC 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG83498.
    GeneTreeiENSGT00720000108792.
    HOGENOMiHOG000036086.
    HOVERGENiHBG068398.
    OMAiCLRRECL.
    OrthoDBiEOG73Z2TT.
    PhylomeDBiB0UZC8.
    TreeFamiTF329913.

    Family and domain databases

    InterProiIPR001007. VWF_C.
    [Graphical view]
    PfamiPF00093. VWC. 1 hit.
    [Graphical view]
    SMARTiSM00214. VWC. 1 hit.
    [Graphical view]
    PROSITEiPS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B0UZC8-1 [UniParc]FASTAAdd to Basket

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    MGPFLPAICV VLLALNAAVS PASVGPEDYP AADEAERTAN NDIIFDDYRG    50
    KGCVDDSGFV YKLGERFFPG HSNCPCVCTE DGPVCDQPEC PKIHPKCTKV 100
    EHNGCCPECK EVKNFCEYRG KTYKILEEFK PSPCEWCRCE PNNEVHCVVA 150
    DCAVPECVNP VYEPEQCCPI CKNGPNCFAG TTIIPAGIEV KVDDCTICRC 200
    HSGDWWKPAQ CLRRECLNGQ ATS 223
    Length:223
    Mass (Da):24,509
    Last modified:April 8, 2008 - v1
    Checksum:i3C34E9E9A4B43640
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB428728 mRNA. Translation: BAH04287.1.
    CR753890 Genomic DNA. Translation: CAQ13566.1.
    RefSeqiNP_001122036.1. NM_001128564.1.
    UniGeneiDr.148397.

    Genome annotation databases

    EnsembliENSDART00000100394; ENSDARP00000091167; ENSDARG00000069134.
    ENSDART00000132911; ENSDARP00000115777; ENSDARG00000069134.
    GeneIDi100148652.
    KEGGidre:100148652.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB428728 mRNA. Translation: BAH04287.1 .
    CR753890 Genomic DNA. Translation: CAQ13566.1 .
    RefSeqi NP_001122036.1. NM_001128564.1.
    UniGenei Dr.148397.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000091167.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000100394 ; ENSDARP00000091167 ; ENSDARG00000069134 .
    ENSDART00000132911 ; ENSDARP00000115777 ; ENSDARG00000069134 .
    GeneIDi 100148652.
    KEGGi dre:100148652.

    Organism-specific databases

    CTDi 402117.
    ZFINi ZDB-GENE-081104-169. vwc2l.

    Phylogenomic databases

    eggNOGi NOG83498.
    GeneTreei ENSGT00720000108792.
    HOGENOMi HOG000036086.
    HOVERGENi HBG068398.
    OMAi CLRRECL.
    OrthoDBi EOG73Z2TT.
    PhylomeDBi B0UZC8.
    TreeFami TF329913.

    Miscellaneous databases

    NextBioi 20792279.
    PROi B0UZC8.

    Gene expression databases

    Bgeei B0UZC8.

    Family and domain databases

    InterProi IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00093. VWC. 1 hit.
    [Graphical view ]
    SMARTi SM00214. VWC. 1 hit.
    [Graphical view ]
    PROSITEi PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family."
      Miwa H., Miyake A., Kouta Y., Shimada A., Yamashita Y., Nakayama Y., Yamauchi H., Konishi M., Itoh N.
      FEBS Lett. 583:3643-3648(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
    2. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.

    Entry informationi

    Entry nameiVWC2L_DANRE
    AccessioniPrimary (citable) accession number: B0UZC8
    Secondary accession number(s): B7X9K3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3