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B0UZC8 (VWC2L_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
von Willebrand factor C domain-containing protein 2-like
Gene names
Name:vwc2l
ORF Names:si:ch211-207d8.1
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in bone differentiation and matrix mineralization By similarity. May play a role in neural development. Ref.1

Subcellular location

Secreted By similarity. Cell junctionsynapse By similarity.

Developmental stage

At 36 hpf, expressed predominantlyin the brain, including several discrete regions in the forebrain, midbrain and hindbrain. Ref.1

Sequence similarities

Contains 2 VWFC domains.

Ontologies

Keywords
   Cellular componentCell junction
Secreted
Synapse
   DomainRepeat
Signal
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnervous system development

Inferred from mutant phenotype Ref.1. Source: ZFIN

   Cellular_componentcell junction

Inferred from electronic annotation. Source: UniProtKB-KW

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

synapse

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 223202von Willebrand factor C domain-containing protein 2-like
PRO_0000348063

Regions

Domain51 – 11060VWFC 1
Domain114 – 17259VWFC 2

Sequences

Sequence LengthMass (Da)Tools
B0UZC8 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 3C34E9E9A4B43640

FASTA22324,509
        10         20         30         40         50         60 
MGPFLPAICV VLLALNAAVS PASVGPEDYP AADEAERTAN NDIIFDDYRG KGCVDDSGFV 

        70         80         90        100        110        120 
YKLGERFFPG HSNCPCVCTE DGPVCDQPEC PKIHPKCTKV EHNGCCPECK EVKNFCEYRG 

       130        140        150        160        170        180 
KTYKILEEFK PSPCEWCRCE PNNEVHCVVA DCAVPECVNP VYEPEQCCPI CKNGPNCFAG 

       190        200        210        220 
TTIIPAGIEV KVDDCTICRC HSGDWWKPAQ CLRRECLNGQ ATS 

« Hide

References

« Hide 'large scale' references
[1]"A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family."
Miwa H., Miyake A., Kouta Y., Shimada A., Yamashita Y., Nakayama Y., Yamauchi H., Konishi M., Itoh N.
FEBS Lett. 583:3643-3648(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
[2]"The zebrafish reference genome sequence and its relationship to the human genome."
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J. expand/collapse author list , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB428728 mRNA. Translation: BAH04287.1.
CR753890 Genomic DNA. Translation: CAQ13566.1.
RefSeqNP_001122036.1. NM_001128564.1.
UniGeneDr.148397.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000091167.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000100394; ENSDARP00000091167; ENSDARG00000069134.
ENSDART00000132911; ENSDARP00000115777; ENSDARG00000069134.
GeneID100148652.
KEGGdre:100148652.

Organism-specific databases

CTD402117.
ZFINZDB-GENE-081104-169. vwc2l.

Phylogenomic databases

eggNOGNOG83498.
GeneTreeENSGT00720000108792.
HOGENOMHOG000036086.
HOVERGENHBG068398.
OMACLRRECL.
OrthoDBEOG73Z2TT.
PhylomeDBB0UZC8.
TreeFamTF329913.

Gene expression databases

BgeeB0UZC8.

Family and domain databases

InterProIPR001007. VWF_C.
[Graphical view]
PfamPF00093. VWC. 1 hit.
[Graphical view]
SMARTSM00214. VWC. 1 hit.
[Graphical view]
PROSITEPS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20792279.
PROB0UZC8.

Entry information

Entry nameVWC2L_DANRE
AccessionPrimary (citable) accession number: B0UZC8
Secondary accession number(s): B7X9K3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: April 8, 2008
Last modified: April 16, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families