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B0UYH6 (RPAP2_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative RNA polymerase II subunit B1 CTD phosphatase rpap2

EC=3.1.3.16
Alternative name(s):
RNA polymerase II-associated protein 2
Gene names
Name:rpap2
ORF Names:si:dkey-63k7.3
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length601 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Associates with the RNA polymerase II complex By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the RPAP2 family.

Contains 1 RTR1-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 601601Putative RNA polymerase II subunit B1 CTD phosphatase rpap2
PRO_0000416289

Regions

Zinc finger71 – 15484RTR1-type
Coiled coil24 – 6239 Potential

Sequences

Sequence LengthMass (Da)Tools
B0UYH6 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 78093E0ED1C0A82F

FASTA60167,549
        10         20         30         40         50         60 
MDAGEVTRKS RPSKSKKKGG KGTQAISAED EAKRREAVKE QLRQKLELER KARQVVERLL 

        70         80         90        100        110        120 
EDSVTEEFLM DCAWHITPAN YKDTVEERSI AKLCGYPMCP NKLTNVPTQQ YKISTKTNKV 

       130        140        150        160        170        180 
YDITERKCFC SNFCYKASKS FELQISKIPL WLRKEESPPE IKLMKQGDGG SSGQEIKLID 

       190        200        210        220        230        240 
KPITEADIDN PIEDIPESNK DLIQGENGDI EQDFVSSVVS NQHKQVHWGK LPKRDEVSED 

       250        260        270        280        290        300 
AAEYSHSEHE QRINGENKDE SESSQTPQPQ KDTTDHPALE KNASEIEGTL ELLNQDKSTQ 

       310        320        330        340        350        360 
QEGENTSSSQ PESDISVPVA GDLNITQVGM SKRSAAGLKG LLKDHHKAKT ASTAISQCLL 

       370        380        390        400        410        420 
ERLRQAFIEW RTKETMIFLY GPDYASGMQL STAGAWEEEQ LDEDDLDEAE VGVRSAEGGP 

       430        440        450        460        470        480 
SRTSAPVPDV ETLRKETEML ELRVREFYKG VCVLPEEVET AAVKETEHTQ DSGKDPPLPL 

       490        500        510        520        530        540 
VDSHAQHQIQ KRIVVEKLSH SLRDIVGPLR LTMSDVINDV NNLVRTFRFT NTNIIHKSPE 

       550        560        570        580        590        600 
WTLIAVVLLS VLTEVSPLLR ESLASVSSLE YISCFMKELK LEDKDLHNLV LLFKPCVPIQ 


T 

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References

[1]"The zebrafish reference genome sequence and its relationship to the human genome."
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J. expand/collapse author list , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR450845 Genomic DNA. Translation: CAQ13680.1.
RefSeqNP_001264859.1. NM_001277930.1.
UniGeneDr.45506.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000056033.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000056034; ENSDARP00000056033; ENSDARG00000038397.
GeneID554138.
KEGGdre:554138.

Organism-specific databases

CTD79871.

Phylogenomic databases

eggNOGNOG241465.
GeneTreeENSGT00390000017965.
HOGENOMHOG000253960.
HOVERGENHBG080953.
OMAIIFRTSC.
OrthoDBEOG7XWPQD.
PhylomeDBB0UYH6.
TreeFamTF331431.

Gene expression databases

BgeeB0UYH6.

Family and domain databases

InterProIPR007308. DUF408.
[Graphical view]
PfamPF04181. RPAP2_Rtr1. 1 hit.
[Graphical view]
PROSITEPS51479. ZF_RTR1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROB0UYH6.

Entry information

Entry nameRPAP2_DANRE
AccessionPrimary (citable) accession number: B0UYH6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: April 8, 2008
Last modified: April 16, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families