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B0UYH6

- RPAP2_DANRE

UniProt

B0UYH6 - RPAP2_DANRE

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Protein

Putative RNA polymerase II subunit B1 CTD phosphatase rpap2

Gene

rpap2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri71 – 15484RTR1-typeAdd
BLAST

GO - Molecular functioni

  1. CTD phosphatase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dephosphorylation of RNA polymerase II C-terminal domain Source: UniProtKB
  2. snRNA transcription Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative RNA polymerase II subunit B1 CTD phosphatase rpap2 (EC:3.1.3.16)
Alternative name(s):
RNA polymerase II-associated protein 2
Gene namesi
Name:rpap2
ORF Names:si:dkey-63k7.3
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 2

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. DNA-directed RNA polymerase II, holoenzyme Source: UniProtKB
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 601601Putative RNA polymerase II subunit B1 CTD phosphatase rpap2PRO_0000416289Add
BLAST

Expressioni

Gene expression databases

BgeeiB0UYH6.

Interactioni

Subunit structurei

Associates with the RNA polymerase II complex.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000056033.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili24 – 6239Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the RPAP2 family.Curated
Contains 1 RTR1-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri71 – 15484RTR1-typeAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG241465.
GeneTreeiENSGT00390000017965.
HOGENOMiHOG000253960.
HOVERGENiHBG080953.
InParanoidiB0UYH6.
OMAiIIFRTSC.
OrthoDBiEOG7XWPQD.
PhylomeDBiB0UYH6.
TreeFamiTF331431.

Family and domain databases

InterProiIPR007308. DUF408.
[Graphical view]
PfamiPF04181. RPAP2_Rtr1. 1 hit.
[Graphical view]
PROSITEiPS51479. ZF_RTR1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0UYH6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDAGEVTRKS RPSKSKKKGG KGTQAISAED EAKRREAVKE QLRQKLELER
60 70 80 90 100
KARQVVERLL EDSVTEEFLM DCAWHITPAN YKDTVEERSI AKLCGYPMCP
110 120 130 140 150
NKLTNVPTQQ YKISTKTNKV YDITERKCFC SNFCYKASKS FELQISKIPL
160 170 180 190 200
WLRKEESPPE IKLMKQGDGG SSGQEIKLID KPITEADIDN PIEDIPESNK
210 220 230 240 250
DLIQGENGDI EQDFVSSVVS NQHKQVHWGK LPKRDEVSED AAEYSHSEHE
260 270 280 290 300
QRINGENKDE SESSQTPQPQ KDTTDHPALE KNASEIEGTL ELLNQDKSTQ
310 320 330 340 350
QEGENTSSSQ PESDISVPVA GDLNITQVGM SKRSAAGLKG LLKDHHKAKT
360 370 380 390 400
ASTAISQCLL ERLRQAFIEW RTKETMIFLY GPDYASGMQL STAGAWEEEQ
410 420 430 440 450
LDEDDLDEAE VGVRSAEGGP SRTSAPVPDV ETLRKETEML ELRVREFYKG
460 470 480 490 500
VCVLPEEVET AAVKETEHTQ DSGKDPPLPL VDSHAQHQIQ KRIVVEKLSH
510 520 530 540 550
SLRDIVGPLR LTMSDVINDV NNLVRTFRFT NTNIIHKSPE WTLIAVVLLS
560 570 580 590 600
VLTEVSPLLR ESLASVSSLE YISCFMKELK LEDKDLHNLV LLFKPCVPIQ

T
Length:601
Mass (Da):67,549
Last modified:April 8, 2008 - v1
Checksum:i78093E0ED1C0A82F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR450845 Genomic DNA. Translation: CAQ13680.1.
RefSeqiNP_001264859.1. NM_001277930.1.
UniGeneiDr.45506.

Genome annotation databases

EnsembliENSDART00000056034; ENSDARP00000056033; ENSDARG00000038397.
GeneIDi554138.
KEGGidre:554138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR450845 Genomic DNA. Translation: CAQ13680.1 .
RefSeqi NP_001264859.1. NM_001277930.1.
UniGenei Dr.45506.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000056033.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000056034 ; ENSDARP00000056033 ; ENSDARG00000038397 .
GeneIDi 554138.
KEGGi dre:554138.

Organism-specific databases

CTDi 79871.

Phylogenomic databases

eggNOGi NOG241465.
GeneTreei ENSGT00390000017965.
HOGENOMi HOG000253960.
HOVERGENi HBG080953.
InParanoidi B0UYH6.
OMAi IIFRTSC.
OrthoDBi EOG7XWPQD.
PhylomeDBi B0UYH6.
TreeFami TF331431.

Miscellaneous databases

PROi B0UYH6.

Gene expression databases

Bgeei B0UYH6.

Family and domain databases

InterProi IPR007308. DUF408.
[Graphical view ]
Pfami PF04181. RPAP2_Rtr1. 1 hit.
[Graphical view ]
PROSITEi PS51479. ZF_RTR1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.

Entry informationi

Entry nameiRPAP2_DANRE
AccessioniPrimary (citable) accession number: B0UYH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3