Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B0UYH6

- RPAP2_DANRE

UniProt

B0UYH6 - RPAP2_DANRE

Protein

Putative RNA polymerase II subunit B1 CTD phosphatase rpap2

Gene

rpap2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri71 – 15484RTR1-typeAdd
    BLAST

    GO - Molecular functioni

    1. CTD phosphatase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dephosphorylation of RNA polymerase II C-terminal domain Source: UniProtKB
    2. snRNA transcription Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative RNA polymerase II subunit B1 CTD phosphatase rpap2 (EC:3.1.3.16)
    Alternative name(s):
    RNA polymerase II-associated protein 2
    Gene namesi
    Name:rpap2
    ORF Names:si:dkey-63k7.3
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 2

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. DNA-directed RNA polymerase II, holoenzyme Source: UniProtKB
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 601601Putative RNA polymerase II subunit B1 CTD phosphatase rpap2PRO_0000416289Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiB0UYH6.

    Interactioni

    Subunit structurei

    Associates with the RNA polymerase II complex.By similarity

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000056033.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili24 – 6239Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RPAP2 family.Curated
    Contains 1 RTR1-type zinc finger.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri71 – 15484RTR1-typeAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG241465.
    GeneTreeiENSGT00390000017965.
    HOGENOMiHOG000253960.
    HOVERGENiHBG080953.
    OMAiIIFRTSC.
    OrthoDBiEOG7XWPQD.
    PhylomeDBiB0UYH6.
    TreeFamiTF331431.

    Family and domain databases

    InterProiIPR007308. DUF408.
    [Graphical view]
    PfamiPF04181. RPAP2_Rtr1. 1 hit.
    [Graphical view]
    PROSITEiPS51479. ZF_RTR1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0UYH6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDAGEVTRKS RPSKSKKKGG KGTQAISAED EAKRREAVKE QLRQKLELER    50
    KARQVVERLL EDSVTEEFLM DCAWHITPAN YKDTVEERSI AKLCGYPMCP 100
    NKLTNVPTQQ YKISTKTNKV YDITERKCFC SNFCYKASKS FELQISKIPL 150
    WLRKEESPPE IKLMKQGDGG SSGQEIKLID KPITEADIDN PIEDIPESNK 200
    DLIQGENGDI EQDFVSSVVS NQHKQVHWGK LPKRDEVSED AAEYSHSEHE 250
    QRINGENKDE SESSQTPQPQ KDTTDHPALE KNASEIEGTL ELLNQDKSTQ 300
    QEGENTSSSQ PESDISVPVA GDLNITQVGM SKRSAAGLKG LLKDHHKAKT 350
    ASTAISQCLL ERLRQAFIEW RTKETMIFLY GPDYASGMQL STAGAWEEEQ 400
    LDEDDLDEAE VGVRSAEGGP SRTSAPVPDV ETLRKETEML ELRVREFYKG 450
    VCVLPEEVET AAVKETEHTQ DSGKDPPLPL VDSHAQHQIQ KRIVVEKLSH 500
    SLRDIVGPLR LTMSDVINDV NNLVRTFRFT NTNIIHKSPE WTLIAVVLLS 550
    VLTEVSPLLR ESLASVSSLE YISCFMKELK LEDKDLHNLV LLFKPCVPIQ 600
    T 601
    Length:601
    Mass (Da):67,549
    Last modified:April 8, 2008 - v1
    Checksum:i78093E0ED1C0A82F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR450845 Genomic DNA. Translation: CAQ13680.1.
    RefSeqiNP_001264859.1. NM_001277930.1.
    UniGeneiDr.45506.

    Genome annotation databases

    EnsembliENSDART00000056034; ENSDARP00000056033; ENSDARG00000038397.
    GeneIDi554138.
    KEGGidre:554138.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR450845 Genomic DNA. Translation: CAQ13680.1 .
    RefSeqi NP_001264859.1. NM_001277930.1.
    UniGenei Dr.45506.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000056033.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000056034 ; ENSDARP00000056033 ; ENSDARG00000038397 .
    GeneIDi 554138.
    KEGGi dre:554138.

    Organism-specific databases

    CTDi 79871.

    Phylogenomic databases

    eggNOGi NOG241465.
    GeneTreei ENSGT00390000017965.
    HOGENOMi HOG000253960.
    HOVERGENi HBG080953.
    OMAi IIFRTSC.
    OrthoDBi EOG7XWPQD.
    PhylomeDBi B0UYH6.
    TreeFami TF331431.

    Miscellaneous databases

    PROi B0UYH6.

    Gene expression databases

    Bgeei B0UYH6.

    Family and domain databases

    InterProi IPR007308. DUF408.
    [Graphical view ]
    Pfami PF04181. RPAP2_Rtr1. 1 hit.
    [Graphical view ]
    PROSITEi PS51479. ZF_RTR1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.

    Entry informationi

    Entry nameiRPAP2_DANRE
    AccessioniPrimary (citable) accession number: B0UYH6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2012
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3