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B0UWT7 (TYSY_HAES2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thymidylate synthase
Short name=TS
Short name=TSase
EC=2.1.1.45
Gene names
Name:thyA
Ordered Locus Names:HSM_0391
OrganismHaemophilus somnus (strain 2336) (Histophilus somni (strain 2336)) [Complete proteome] [HAMAP]
Taxonomic identifier228400 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Histophilus

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity. HAMAP MF_00008

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP MF_00008

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP MF_00008

Subunit structure

Homodimer By similarity. HAMAP MF_00008

Subcellular location

Cytoplasm By similarity HAMAP MF_00008.

Sequence similarities

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   Cellular componentCytoplasm
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdTMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionthymidylate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 283283Thymidylate synthase HAMAP MF_00008
PRO_1000073877

Sites

Active site1601 By similarity

Sequences

Sequence LengthMass (Da)Tools
B0UWT7 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: AB6C93B6193EDB0E

FASTA28332,779
        10         20         30         40         50         60 
MRQYLNLCQR IIDQGHWVEN ERTGKRCLTV INADLTYDVA NNQFPLITTR KSYWKAAIAE 

        70         80         90        100        110        120 
FLGYIRGYDN AADFRKLGTK TWDANANENQ AWLNNPVRKG TDDMGRVYGV QGRRWRKPNG 

       130        140        150        160        170        180 
ETVDQLRKIV NNLSKGIDDR GEILTFFNPG EIDLGCLRPC MHTHTFSLLG DTLYLTSYQR 

       190        200        210        220        230        240 
SCDVPLGLNF NQIQVFTFLA LMAQITGKKA GQAYHKIINA HIYEDQFELM RDVQLKREPF 

       250        260        270        280 
PLPRLEINPD IKTLEDLETW VTMDDFKVIG YQCHEAIKYP FSV

« Hide

References

[1]"Complete sequence of Haemophilus somnus 2336."
US DOE Joint Genome Institute
Siddaramappa S., Duncan A.J., Challacombe J.F., Rainey D., Gillaspy A.F., Carson M., Gipson J., Gipson M., Bruce D., Detter J.C., Han C.S., Land M., Tapia R., Thompson L.S., Orvis J., Zaitshik J., Barnes G., Brettin T.S., Dyer D.W., Inzana T.J.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2336.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000947 Genomic DNA. Translation: ACA32031.1.
RefSeqYP_001783740.1. NC_010519.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB0UWT7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6108172.
GenomeReviewsGene locus HSM_0391 in contig CP000947_GR.
KEGGhsm:HSM_0391.
PATRIC20197797. VBIHaeSom93646_0408.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG588098.
OMAPIKYPFS.
ProtClustDBPRK01827.

Enzyme and pathway databases

BioCycHSOM228400:HSM_0391-MONOMER.

Family and domain databases

HAMAPMF_00008. Thymidy_synth_bact.
[Tree]
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
Gene3DG3DSA:3.30.572.10. Thymidylat_synth_C. 1 hit.
KOK00560.
PANTHERPTHR11549:SF2. Thymidylat_synth_C. 1 hit.
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. Thymidylat_synth_C. 1 hit.
TIGRFAMsTIGR03284. Thym_sym. 1 hit.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYSY_HAES2
AccessionPrimary (citable) accession number: B0UWT7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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