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B0UWT1

- PUR9_HISS2

UniProt

B0UWT1 - PUR9_HISS2

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, HSM_0385
Organism
Histophilus somni (strain 2336) (Haemophilus somnus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciHSOM228400:GHWT-395-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:HSM_0385
OrganismiHistophilus somni (strain 2336) (Haemophilus somnus)
Taxonomic identifieri228400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
ProteomesiUP000008543: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000076483Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi228400.HSM_0385.

Structurei

3D structure databases

ProteinModelPortaliB0UWT1.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B0UWT1-1 [UniParc]FASTAAdd to Basket

« Hide

MQLNHPIRQA LLSVSDKSGI VEFAQGLVRR GVKLLSTGGT AKLLAENGIP    50
VTEVSDYTGF PEMMEGRVKT LHPKIHGGIL GRRGIDDEVM MQHQIDAIDM 100
VVVNLYPFAA TVAKPDCTLE DAVENIDIGG PTMVRSAAKN HQHVAIVVNN 150
SDFNAILAEM DQNRNSLTLE TRFDLAIKAF EHTAQYDSMI ANYFGQMVKP 200
YFRAEEEAEA KCGQFPRTLN LNFIRKQSMR YGENGHQKAA FYVEQDVKEA 250
SVSTAKQLQG KALSYNNIAD TDAALECVKS FSEPACVIVK HANPCGVALG 300
KDILEAYNRA YQTDPTSAFG GIIAFNRELD EDTAKAIIER QFVEVIIAPT 350
VSSAAQEIVK SKKNVRLLMC GNWESAIQRL DFKRVNGGLL VQEADLSMVD 400
LADLEVVSKR QPTKQELEDL LFCWKVAKFV KSNAIVYAKN NQTVGIGAGQ 450
MSRVYSAKIA GIKAKDEGLE VKGCVMASDA FFPFRDGIDA AAKVGIECVI 500
HPGGSMRDQE VIDAANEHNM VMVLTKMRHF RH 532
Length:532
Mass (Da):58,579
Last modified:April 8, 2008 - v1
Checksum:i9FD671BD0387897F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000947 Genomic DNA. Translation: ACA32024.1.
RefSeqiYP_001783734.1. NC_010519.1.

Genome annotation databases

EnsemblBacteriaiACA32024; ACA32024; HSM_0385.
GeneIDi6108165.
KEGGihsm:HSM_0385.
PATRICi20197783. VBIHaeSom93646_0401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000947 Genomic DNA. Translation: ACA32024.1 .
RefSeqi YP_001783734.1. NC_010519.1.

3D structure databases

ProteinModelPortali B0UWT1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228400.HSM_0385.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA32024 ; ACA32024 ; HSM_0385 .
GeneIDi 6108165.
KEGGi hsm:HSM_0385.
PATRICi 20197783. VBIHaeSom93646_0401.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci HSOM228400:GHWT-395-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2336.

Entry informationi

Entry nameiPUR9_HISS2
AccessioniPrimary (citable) accession number: B0UWT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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