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B0UWS9 (B0UWS9_HAES2) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
EC=6.3.4.13 HAMAP-Rule MF_00138
Alternative name(s):
GARS HAMAP-Rule MF_00138
Glycinamide ribonucleotide synthetase HAMAP-Rule MF_00138
Phosphoribosylglycinamide synthetase HAMAP-Rule MF_00138
Gene names
Name:purD HAMAP-Rule MF_00138
Ordered Locus Names:HSM_0383
OrganismHaemophilus somnus (strain 2336) (Histophilus somni (strain 2336)) [Complete proteome] [HAMAP] EMBL ACA32022.1
Taxonomic identifier228400 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Histophilus ›

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds (magnesium or manganese,ion) per subunit By similarity. HAMAP-Rule MF_00138

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family. HAMAP-Rule MF_00138

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00138

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain113 – 320208ATP-grasp By similarity HAMAP-Rule MF_00138
Nucleotide binding139 – 20062ATP By similarity HAMAP-Rule MF_00138

Sites

Metal binding2901Magnesium or manganese By similarity HAMAP-Rule MF_00138
Metal binding2921Magnesium or manganese By similarity HAMAP-Rule MF_00138

Sequences

Sequence LengthMass (Da)Tools
B0UWS9 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: C69F503E301BC83D

FASTA43246,449
        10         20         30         40         50         60 
MNILIIGNGG REHALVWKVA QSPLASKIFV APGNAGTAME TDGKCAVENV AISATDIDAL 

        70         80         90        100        110        120 
VNFAQENQIG LTIVGPEAPL VLGVVDAFRA SGLKIFGPTQ AAAQLEGSKA FTKDFLARHH 

       130        140        150        160        170        180 
IPTAEYRSFT DAEKAIAYVR EKDAPIVVKA DGLATGKGVI VAMTLAEAEK AIQDMLSGNA 

       190        200        210        220        230        240 
FGKAGSKVVI EEFLEGEEAS FIVMVDGKNV EPMATSQDHK RVGENDTGPN TGGMGAYSPA 

       250        260        270        280        290        300 
PVVTPEIHTR IMQQIIYPTV NGMAKEGNIY TGFLYAGLMI DKHGQPKVIE FNCRFGDPET 

       310        320        330        340        350        360 
QPVMMRMRSD LVELCLNACE GKLDQVKSEW SEQAALGIVL AAEGYPNNYR KGDEIQGLPI 

       370        380        390        400        410        420 
SAGENQKVFL AGVEQKGERL LTNGGRVLCV TAMGENVFAA QQQALKLAKQ IQWSGRFYRQ 

       430 
DIGYRAVARE NQ

« Hide

References

[1]"Complete sequence of Haemophilus somnus 2336."
US DOE Joint Genome Institute
Siddaramappa S., Duncan A.J., Challacombe J.F., Rainey D., Gillaspy A.F., Carson M., Gipson J., Gipson M., Bruce D., Detter J.C., Han C.S., Land M., Tapia R., Thompson L.S., Orvis J., Zaitshik J., Barnes G., Brettin T.S., Dyer D.W., Inzana T.J.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2336.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000947 Genomic DNA. Translation: ACA32022.1.
RefSeqYP_001783732.1. NC_010519.1.

3D structure databases

ProteinModelPortalB0UWS9.
SMRB0UWS9. Positions 1-429.
ModBaseSearch...

Protein-protein interaction databases

STRING228400.HSM_0383.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA32022; ACA32022; HSM_0383.
GeneID6108163.
KEGGhsm:HSM_0383.
PATRIC20197779. VBIHaeSom93646_0399.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0151.
HOGENOMHOG000033463.
KOK01945.
OMAMGAYTPL.
ProtClustDBPRK00885.

Enzyme and pathway databases

BioCycHSOM228400:GHWT-1327-MONOMER.
UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
SSF51246. Rudmnt_hyb_motif. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB0UWS9_HAES2
AccessionPrimary (citable) accession number: B0UWS9
Entry history
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info