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B0UWS9

- B0UWS9_HISS2

UniProt

B0UWS9 - B0UWS9_HISS2

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Protein

Phosphoribosylamine--glycine ligase

Gene

purD

Organism
Histophilus somni (strain 2336) (Haemophilus somnus)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi290 – 2901Magnesium or manganeseUniRule annotation
Metal bindingi292 – 2921Magnesium or manganeseUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi139 – 20062ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. manganese ion binding Source: UniProtKB-HAMAP
  4. phosphoribosylamine-glycine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-HAMAP
  2. purine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Purine biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciHSOM228400:GHWT-393-MONOMER.
UniPathwayiUPA00074; UER00125.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylamine--glycine ligaseUniRule annotation (EC:6.3.4.13UniRule annotation)
Alternative name(s):
GARSUniRule annotation
Glycinamide ribonucleotide synthetaseUniRule annotation
Phosphoribosylglycinamide synthetaseUniRule annotation
Gene namesi
Name:purDUniRule annotation
Ordered Locus Names:HSM_0383Imported
OrganismiHistophilus somni (strain 2336) (Haemophilus somnus)Imported
Taxonomic identifieri228400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
ProteomesiUP000008543: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi228400.HSM_0383.

Structurei

3D structure databases

ProteinModelPortaliB0UWS9.
SMRiB0UWS9. Positions 1-429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini113 – 320208ATP-graspUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the GARS family.UniRule annotation
Contains 1 ATP-grasp domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0151.
HOGENOMiHOG000033463.
KOiK01945.
OrthoDBiEOG69SKD1.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPiMF_00138. GARS.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR00877. purD. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0UWS9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNILIIGNGG REHALVWKVA QSPLASKIFV APGNAGTAME TDGKCAVENV
60 70 80 90 100
AISATDIDAL VNFAQENQIG LTIVGPEAPL VLGVVDAFRA SGLKIFGPTQ
110 120 130 140 150
AAAQLEGSKA FTKDFLARHH IPTAEYRSFT DAEKAIAYVR EKDAPIVVKA
160 170 180 190 200
DGLATGKGVI VAMTLAEAEK AIQDMLSGNA FGKAGSKVVI EEFLEGEEAS
210 220 230 240 250
FIVMVDGKNV EPMATSQDHK RVGENDTGPN TGGMGAYSPA PVVTPEIHTR
260 270 280 290 300
IMQQIIYPTV NGMAKEGNIY TGFLYAGLMI DKHGQPKVIE FNCRFGDPET
310 320 330 340 350
QPVMMRMRSD LVELCLNACE GKLDQVKSEW SEQAALGIVL AAEGYPNNYR
360 370 380 390 400
KGDEIQGLPI SAGENQKVFL AGVEQKGERL LTNGGRVLCV TAMGENVFAA
410 420 430
QQQALKLAKQ IQWSGRFYRQ DIGYRAVARE NQ
Length:432
Mass (Da):46,449
Last modified:April 8, 2008 - v1
Checksum:iC69F503E301BC83D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000947 Genomic DNA. Translation: ACA32022.1.
RefSeqiWP_012341235.1. NC_010519.1.
YP_001783732.1. NC_010519.1.

Genome annotation databases

EnsemblBacteriaiACA32022; ACA32022; HSM_0383.
GeneIDi6108163.
KEGGihsm:HSM_0383.
PATRICi20197779. VBIHaeSom93646_0399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000947 Genomic DNA. Translation: ACA32022.1 .
RefSeqi WP_012341235.1. NC_010519.1.
YP_001783732.1. NC_010519.1.

3D structure databases

ProteinModelPortali B0UWS9.
SMRi B0UWS9. Positions 1-429.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228400.HSM_0383.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA32022 ; ACA32022 ; HSM_0383 .
GeneIDi 6108163.
KEGGi hsm:HSM_0383.
PATRICi 20197779. VBIHaeSom93646_0399.

Phylogenomic databases

eggNOGi COG0151.
HOGENOMi HOG000033463.
KOi K01945.
OrthoDBi EOG69SKD1.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00125 .
BioCyci HSOM228400:GHWT-393-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPi MF_00138. GARS.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view ]
Pfami PF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR00877. purD. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2336Imported.

Entry informationi

Entry nameiB0UWS9_HISS2
AccessioniPrimary (citable) accession number: B0UWS9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 26, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3