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B0UWE3

- TRMB_HISS2

UniProt

B0UWE3 - TRMB_HISS2

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, HSM_1828
Organism
Histophilus somni (strain 2336) (Haemophilus somnus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801S-adenosyl-L-methionine By similarity
Binding sitei105 – 1051S-adenosyl-L-methionine By similarity
Binding sitei132 – 1321S-adenosyl-L-methionine By similarity
Active sitei155 – 1551 By similarity
Binding sitei155 – 1551S-adenosyl-L-methionine By similarity
Binding sitei159 – 1591Substrate By similarity
Binding sitei191 – 1911Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHSOM228400:GHWT-1868-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:HSM_1828
OrganismiHistophilus somni (strain 2336) (Haemophilus somnus)
Taxonomic identifieri228400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
ProteomesiUP000008543: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_1000084443Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi228400.HSM_1828.

Structurei

3D structure databases

ProteinModelPortaliB0UWE3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni228 – 2314Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0UWE3-1 [UniParc]FASTAAdd to Basket

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MTEQKITFAD QKRKTVEIAE FTEDGRYKRK VRSFVLRTGR LSEFQRNMMN    50
NNWATLGLEY QTTAFDFTQI YGNTNPVILE IGFGMGKSLV EMALQNPDKN 100
YLGIEVHTPG VGACIAYAVE KQVKNLRVIC HDATEILQDC IADNSLAGLQ 150
LFFPDPWHKT KHHKRRIVQP HFVEKIQQKL VPNGFVHMAT DWENYAEYML 200
EVLTSAVGLH NTSATNDYIP RPDFRPLTKF EQRGHKLGHG VWDLFFIKNI 250
T 251
Length:251
Mass (Da):28,948
Last modified:April 8, 2008 - v1
Checksum:iFBE73D447F17A7C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000947 Genomic DNA. Translation: ACA31614.1.
RefSeqiYP_001785146.1. NC_010519.1.

Genome annotation databases

EnsemblBacteriaiACA31614; ACA31614; HSM_1828.
GeneIDi6107752.
KEGGihsm:HSM_1828.
PATRICi20200924. VBIHaeSom93646_1925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000947 Genomic DNA. Translation: ACA31614.1 .
RefSeqi YP_001785146.1. NC_010519.1.

3D structure databases

ProteinModelPortali B0UWE3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228400.HSM_1828.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA31614 ; ACA31614 ; HSM_1828 .
GeneIDi 6107752.
KEGGi hsm:HSM_1828.
PATRICi 20200924. VBIHaeSom93646_1925.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci HSOM228400:GHWT-1868-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2336.

Entry informationi

Entry nameiTRMB_HISS2
AccessioniPrimary (citable) accession number: B0UWE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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