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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Histophilus somni (strain 2336) (Haemophilus somnus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80S-adenosyl-L-methionineUniRule annotation1
Binding sitei105S-adenosyl-L-methionineUniRule annotation1
Binding sitei132S-adenosyl-L-methionineUniRule annotation1
Active sitei155By similarity1
Binding sitei155S-adenosyl-L-methionineUniRule annotation1
Binding sitei159SubstrateUniRule annotation1
Binding sitei191SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHSOM228400:G1GB8-1913-MONOMER
UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:HSM_1828
OrganismiHistophilus somni (strain 2336) (Haemophilus somnus)
Taxonomic identifieri228400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
Proteomesi
  • UP000008543 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000844431 – 251tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST251

Proteomic databases

PRIDEiB0UWE3

Structurei

3D structure databases

ProteinModelPortaliB0UWE3
SMRiB0UWE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni228 – 231Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000073968
KOiK03439
OMAiPDPWHKS
OrthoDBiPOG091H015P

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

B0UWE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEQKITFAD QKRKTVEIAE FTEDGRYKRK VRSFVLRTGR LSEFQRNMMN
60 70 80 90 100
NNWATLGLEY QTTAFDFTQI YGNTNPVILE IGFGMGKSLV EMALQNPDKN
110 120 130 140 150
YLGIEVHTPG VGACIAYAVE KQVKNLRVIC HDATEILQDC IADNSLAGLQ
160 170 180 190 200
LFFPDPWHKT KHHKRRIVQP HFVEKIQQKL VPNGFVHMAT DWENYAEYML
210 220 230 240 250
EVLTSAVGLH NTSATNDYIP RPDFRPLTKF EQRGHKLGHG VWDLFFIKNI

T
Length:251
Mass (Da):28,948
Last modified:April 8, 2008 - v1
Checksum:iFBE73D447F17A7C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000947 Genomic DNA Translation: ACA31614.1
RefSeqiWP_012340923.1, NC_010519.1

Genome annotation databases

EnsemblBacteriaiACA31614; ACA31614; HSM_1828
GeneIDi31488135
KEGGihsm:HSM_1828

Similar proteinsi

Entry informationi

Entry nameiTRMB_HISS2
AccessioniPrimary (citable) accession number: B0UWE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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